Publications

• Sura, M., Daddam, J. R., Gallagher, K., Bernstein, I., Ahmad, G., VandeHaar, M., & Zhou, Z. (2025). Branched-chain amino acid and ketoacid supplementation differentially modulate amino acid and ketoacid metabolisms and profiles in fresh cows. Journal of Dairy Science. https://doi.org/10.3168/jds.2025-26634

• Daddam JR, Sura M, Sarmikasoglou E, Ahmad G, Naughton S, Mills M, White HM, VandeHaar M, Zhou Z. Differences in amino acid and fatty acid metabolism contribute to variability in dairy cattle feed efficiency. J Dairy Sci. 2025 Aug;108(8):8367-8379. doi: 10.3168/jds.2025-26468. Epub 2025 May 28. PMID: 40447084. https://doi.org/10.3168/jds.2025-26468

• Daddam, J. R., Sura, M., Vocelle, D., Laguna, J. G., Gallagher, K., & Zhou, Z. (2025). The supply of branched-chain amino acids and branched-chain keto acids alter lipid metabolism, oxidative stress, and apoptosis in primary bovine hepatocytes. The Journal of Nutritional Biochemistry, 137, 109839. https://doi.org/10.1016/j.jnutbio.2025.109839 

• Cinzori, M. E., M. Nicol, A. L. Dewald, J. M. Goodrich, Z. Zhou, J. C. Gardiner, J. M. Kerver, D. C. Dolinoy, N. Talge, and R. S. Strakovsky. 2024. Maternal mitochondrial DNA copy number and methylation as possible predictors of pregnancy outcomes in a Michigan pregnancy cohort. Environ Epigenet 10(1):dvae021. https://doi.org/10.1093/eep/dvae021 

• Huang, Y., P. Chen, H. Cao, Z. Zhou, and T. Xu. 2024. Characterization of Pseudomonas aeruginosa Isolated from Bovine Mastitis in Northern Jiangsu Province and Correlation to Drug Resistance and Biofilm Formability. Animals 14(22). https://doi.org/10.3390/ani14223290

• Ahmad, G., J. R. Daddam, E. Trevisi, M. Mezzetti, G. Lovotti, E. Puda, K. Gallagher, I. Bernstein, M. Vandehaar, and Z. Zhou. 2024. Effects of abomasal infusion of branched-chain amino acids or branched-chain keto-acids on liver function, inflammation, and oxidative stress in multiparous fresh cows. J Dairy Sci. https://doi.org/10.3168/jds.2024-24914 

• Gallagher, K., I. Bernstein, C. Collings, D. Main, G. Ahmad, S. Naughton, J. Daddam, V. Mavangira, M. Vandehaar, and Z. Zhou. 2024. Abomasal infusion of branched-chain amino acids or branched-chain keto-acids alter lactation performance and liver triglycerides in fresh cows. Journal of Animal Science and Biotechnology 15(1):13. doi:10.1186/s40104-023-00973-7. https://doi.org/10.1186/s40104-023-00973-7

• Ryva, B. A., Z. Zhou, J. M. Goodrich, and R. S. Strakovsky. 2023. The potential role of environmental factors in modulating mitochondrial DNA epigenetic marks. Vitamins and hormones 122:107-145. https://doi.org/10.1016/bs.vh.2023.01.011 

• Martin, M. J., R. S. Pralle, I. R. Bernstein, M. J. VandeHaar, K. A. Weigel, Z. Zhou, and H. M. White. 2021. Circulating Metabolites Indicate Differences in High and Low Residual Feed Intake Holstein Dairy Cows. Metabolites 11(12). https://doi.org/10.3390/metabo11120868

• Gao, S., Z. Zhou, J. Wang, J. Loor, M. Bionaz, L. Ma, and D. Bu. 2020. Diet Composition Affects Liver and Mammary Tissue Transcriptome in Primiparous Holstein Dairy Cows. Animals : an open access journal from MDPI 10(7). doi:10.3390/ani10071191. https://doi.org/10.3390/ani10071191

• McFadden, J. W., C. L. Girard, S. Tao, Z. Zhou, J. K. Bernard, M. Duplessis, and H. M. White. 2020. Symposium review: One-carbon metabolism and methyl donor nutrition in the dairy cow. J Dairy Sci 103(6):5668-5683. doi:10.3168/jds.2019-17319. https://doi.org/10.3168/jds.2019-17319

• Zhou, Z., J. M. Goodrich, and R. S. Strakovsky. 2020. Mitochondrial Epigenetics and Environmental Health: Making a Case for Endocrine Disrupting Chemicals. Toxicological sciences : an official journal of the Society of Toxicology 178(1):16-25. doi:10.1093/toxsci/kfaa129. https://doi.org/10.1093/toxsci/kfaa129

• Asiamah, E. K., M. Vailati-Riboni, Z. Zhou, T. Xu, J. J. Loor, K. Schimmel, and M. Worku. 2019. Rumen-protected methionine supplementation during the peripartal period alters the expression of galectin genes associated with inflammation in peripheral neutrophils and secretion in plasma of Holstein cows. J Dairy Res 86(4):394-398. doi:10.1017/S0022029919000736. https://doi.org/10.1017/S0022029919000736 

• Gao, S. T., L. Ma, Z. Zhou, Z. K. Zhou, L. H. Baumgard, D. Jiang, M. Bionaz, and D. P. Bu. 2019. Heat stress negatively affects the transcriptome related to overall metabolism and milk protein synthesis in mammary tissue of midlactating dairy cows. Physiol Genomics 51(8):400-409. doi:10.1152/physiolgenomics.00039.2019. https://doi.org/10.1152/physiolgenomics.00039.2019 

• Abdelmegeid, M. K., A. A. Elolimy, Z. Zhou, V. Lopreiato, J. C. McCann, and J. J. Loor. 2018. Rumen-protected methionine during the peripartal period in dairy cows and its effects on abundance of major species of ruminal bacteria. J Anim Sci Biotechnol 9:17. doi:10.1186/s40104-018-0230-8. https://doi.org/10.1186/s40104-018-0230-8

• Alharthi, A., Z. Zhou, V. Lopreiato, E. Trevisi, and J. J. Loor. 2018. Body condition score prior to parturition is associated with plasma and adipose tissue biomarkers of lipid metabolism and inflammation in Holstein cows. J Anim Sci Biotechnol 9:12. doi:10.1186/s40104-017-0221-1. https://doi.org/10.1186/s40104-017-0221-1

• Dong, X., Z. Zhou, B. Saremi, A. Helmbrecht, Z. Wang, and J. J. Loor. 2018. Varying the ratio of Lys:Met while maintaining the ratios of Thr:Phe, Lys:Thr, Lys:His, and Lys:Val alters mammary cellular metabolites, mammalian target of rapamycin signaling, and gene transcription. J Dairy Sci 101(2):1708-1718. doi:10.3168/jds.2017-13351. https://doi.org/10.3168/jds.2017-13351

• Dong, X., Z. Zhou, L. Wang, B. Saremi, A. Helmbrecht, Z. Wang, and J. J. Loor. 2018. Increasing the availability of threonine, isoleucine, valine, and leucine relative to lysine while maintaining an ideal ratio of lysine:methionine alters mammary cellular metabolites, mammalian target of rapamycin signaling, and gene transcription. J Dairy Sci 101(6):5502-5514. doi:10.3168/jds.2017-13707. https://doi.org/10.3168/jds.2017-13707

• Han, L. Q., Z. Zhou, Y. Ma, F. Batistel, J. S. Osorio, and J. J. Loor. 2018. Phosphorylation of nuclear factor erythroid 2-like 2 (NFE2L2) in mammary tissue of Holstein cows during the periparturient period is associated with mRNA abundance of antioxidant gene networks. J Dairy Sci 101(7):6511-6522. doi:10.3168/jds.2017-14257. https://doi.org/10.3168/jds.2017-14257

• Jacometo, C. B., A. S. Alharthi, Z. Zhou, D. Luchini, and J. J. Loor. 2018. Maternal supply of methionine during late pregnancy is associated with changes in immune function and abundance of microRNA and mRNA in Holstein calf polymorphonuclear leukocytes. J Dairy Sci 101(9):8146-8158. doi:10.3168/jds.2018-14428. https://doi.org/10.3168/jds.2018-14428

• Lopreiato, V., A. Hosseini, F. Rosa, Z. Zhou, A. Alharthi, E. Trevisi, and J. J. Loor. 2018. Dietary energy level affects adipose depot mass but does not impair in vitro subcutaneous adipose tissue response to short-term insulin and tumor necrosis factor-alpha challenge in nonlactating, nonpregnant Holstein cows. J Dairy Sci 101(11):10206-10219. doi:10.3168/jds.2018-14389. https://doi.org/10.3168/jds.2018-14389

• Stella, S. L., D. A. Velasco-Acosta, C. Skenandore, Z. Zhou, A. Steelman, D. Luchini, and F. C. Cardoso. 2018. Improved uterine immune mediators in Holstein cows supplemented with rumen-protected methionine and discovery of neutrophil extracellular traps (NET). Theriogenology 114:116-125. doi:10.1016/j.theriogenology.2018.03.033. https://doi.org/10.1016/j.theriogenology.2018.03.033

• Zhou, Y., Z. Zhou, J. Peng, and J. J. Loor. 2018. Methionine and valine activate the mammalian target of rapamycin complex 1 pathway through heterodimeric amino acid taste receptor (TAS1R1/TAS1R3) and intracellular Ca(2+) in bovine mammary epithelial cells. J Dairy Sci 101(12):11354-11363. doi:10.3168/jds.2018-14461. https://doi.org/10.3168/jds.2018-14461

• Zhou, Y. F., Z. Zhou, F. Batistel, I. Martinez-Cortes, R. T. Pate, D. L. Luchini, and J. J. Loor. 2018. Methionine and choline supply alter transmethylation, transsulfuration, and cytidine 5'-diphosphocholine pathways to different extents in isolated primary liver cells from dairy cows. J Dairy Sci 101(12):11384-11395. doi:10.3168/jds.2017-14236. https://doi.org/10.3168/jds.2017-14236

• Zhou, Z., F. Ferdous, P. Montagner, D. N. Luchini, M. N. Correa, and J. J. Loor. 2018. Methionine and choline supply during the peripartal period alter polymorphonuclear leukocyte immune response and immunometabolic gene expression in Holstein cows. J Dairy Sci 101(11):10374-10382. doi:10.3168/jds.2018-14972. https://doi.org/10.3168/jds.2018-14972

• Acosta, D. A. V., M. I. Rivelli, C. Skenandore, Z. Zhou, D. H. Keisler, D. Luchini, M. N. Correa, and F. C. Cardoso. 2017. Effects of rumen-protected methionine and choline supplementation on steroidogenic potential of the first postpartum dominant follicle and expression of immune mediators in Holstein cows. Theriogenology 96:1-9. doi:10.1016/j.theriogenology.2017.03.022. https://doi.org/10.1016/j.theriogenology

• Agrawal, A., A. Alharthi, M. Vailati-Riboni, Z. Zhou, and J. J. Loor. 2017. Expression of fatty acid sensing G-protein coupled receptors in peripartal Holstein cows. J Anim Sci Biotechnol 8:20. doi:10.1186/s40104-017-0150-z. https://doi.org/10.1186/s40104-017-0150-z

• Arroyo, J. M., A. Hosseini, Z. Zhou, A. Alharthi, E. Trevisi, J. S. Osorio, and J. J. Loor. 2017. Reticulo-rumen mass, epithelium gene expression, and systemic biomarkers of metabolism and inflammation in Holstein dairy cows fed a high-energy diet. J Dairy Sci 100(11):9352-9360. doi:10.3168/jds.2017-12866. https://doi.org/10.3168/jds.2017-12866

• Hosseini, A., M. Salman, Z. Zhou, J. K. Drackley, E. Trevisi, and J. J. Loor. 2017. Level of dietary energy and 2,4-thiazolidinedione alter molecular and systemic biomarkers of inflammation and liver function in Holstein cows. J Anim Sci Biotechnol 8:64. doi:10.1186/s40104-017-0196-y. https://doi.org/10.1186/s40104-017-0196-y

• Jacometo, C. B., Z. Zhou, D. Luchini, M. N. Correa, and J. J. Loor. 2017. Maternal supplementation with rumen-protected methionine increases prepartal plasma methionine concentration and alters hepatic mRNA abundance of 1-carbon, methionine, and transsulfuration pathways in neonatal Holstein calves. J Dairy Sci 100(4):3209-3219. doi:10.3168/jds.2016-11656. https://doi.org/10.3168/jds.2016-11656

• Skenandore, C. S., D. A. Velasco Acosta, Z. Zhou, M. I. Rivelli, M. N. Correa, D. N. Luchini, and F. C. Cardoso. 2017. Effects of rumen-protected methionine and choline supplementation on vaginal discharge and uterine cytology of Holstein cows. Int J Vet Sci Med 5(1):1-7. doi:10.1016/j.ijvsm.2017.05.001. https://doi.org/10.1016/j.ijvsm.2017.05.001

• Vailati-Riboni, M., Z. Zhou, C. B. Jacometo, A. Minuti, E. Trevisi, D. N. Luchini, and J. J. Loor. 2017. Supplementation with rumen-protected methionine or choline during the transition period influences whole-blood immune response in periparturient dairy cows. J Dairy Sci 100(5):3958-3968. doi:10.3168/jds.2016-11812. https://doi.org/10.3168/jds.2016-11812

• Zhou, Z., T. A. Garrow, X. Dong, D. N. Luchini, and J. J. Loor. 2017. Hepatic Activity and Transcription of Betaine-Homocysteine Methyltransferase, Methionine Synthase, and Cystathionine Synthase in Periparturient Dairy Cows Are Altered to Different Extents by Supply of Methionine and Choline. J Nutr 147(1):11-19. doi:10.3945/jn.116.240234. https://doi.org/10.3945/jn.116.240234

• Zhou, Z., E. Trevisi, D. N. Luchini, and J. J. Loor. 2017. Differences in liver functionality indexes in peripartal dairy cows fed rumen-protected methionine or choline are associated with performance, oxidative stress status, and plasma amino acid profiles. J Dairy Sci 100(8):6720-6732. doi:10.3168/jds.2016-12299. https://doi.org/10.3168/jds.2016-12299

• Acosta, D. A. V., A. C. Denicol, P. Tribulo, M. I. Rivelli, C. Skenandore, Z. Zhou, D. Luchini, M. N. Correa, P. J. Hansen, and F. C. Cardoso. 2016. Effects of rumen-protected methionine and choline supplementation on the preimplantation embryo in Holstein cows. Theriogenology 85(9):1669-1679. doi:10.1016/j.theriogenology.2016.01.024. https://doi.org/10.1016/j.theriogenology 

• Jacometo, C. B., Z. Zhou, D. Luchini, E. Trevisi, M. N. Correa, and J. J. Loor. 2016. Maternal rumen-protected methionine supplementation and its effect on blood and liver biomarkers of energy metabolism, inflammation, and oxidative stress in neonatal Holstein calves. J Dairy Sci 99(8):6753-6763. doi:10.3168/jds.2016-11018. https://doi.org/10.3168/jds.2016-11018 

• Osorio, J. S., C. B. Jacometo, Z. Zhou, D. Luchini, F. C. Cardoso, and J. J. Loor. 2016. Hepatic global DNA and peroxisome proliferator-activated receptor alpha promoter methylation are altered in peripartal dairy cows fed rumen-protected methionine. J Dairy Sci 99(1):234-244. doi:10.3168/jds.2015-10157. https://doi.org/10.3168/jds.2015-10157 

• Zhou, Y., T. Song, J. Peng, Z. Zhou, H. Wei, R. Zhou, S. Jiang, and J. Peng. 2016. SIRT1 suppresses adipogenesis by activating Wnt/β-catenin signaling in vivo and in vitro. Oncotarget 7(47):77707-77720. doi:10.18632/oncotarget.12774. https://doi.org/10.18632/oncotarget.12774 

• Zhou, Z., O. Bulgari, M. Vailati-Riboni, E. Trevisi, M. A. Ballou, F. C. Cardoso, D. N. Luchini, and J. J. Loor. 2016. Rumen-protected methionine compared with rumen-protected choline improves immunometabolic status in dairy cows during the peripartal period. J Dairy Sci 99(11):8956-8969. doi:10.3168/jds.2016-10986. https://doi.org/10.3168/jds.2016-10986 

• Zhou, Z., J. J. Loor, F. Piccioli-Cappelli, F. Librandi, G. E. Lobley, and E. Trevisi. 2016. Circulating amino acids in blood plasma during the peripartal period in dairy cows with different liver functionality index. J Dairy Sci 99(3):2257-2267. doi:10.3168/jds.2015-9805. https://doi.org/10.3168/jds.2015-9805

• Zhou, Z., M. Vailati-Riboni, D. N. Luchini, and J. J. Loor. 2016. Methionine and Choline Supply during the Periparturient Period Alter Plasma Amino Acid and One-Carbon Metabolism Profiles to Various Extents: Potential Role in Hepatic Metabolism and Antioxidant Status. Nutrients 9(1). doi:10.3390/nu9010010. https://doi.org/10.3390/nu9010010 

• Zhou, Z., M. Vailati-Riboni, E. Trevisi, J. K. Drackley, D. N. Luchini, and J. J. Loor. 2016. Better postpartal performance in dairy cows supplemented with rumen-protected methionine compared with choline during the peripartal period. J Dairy Sci 99(11):8716-8732. doi:10.3168/jds.2015-10525. https://doi.org/10.3168/jds.2015-10525 

• Li, Y., A. R. Zhang, H. F. Luo, H. Wei, Z. Zhou, J. Peng, and Y. J. Ru. 2015. In vitro and in vivo digestibility of corn starch for weaned pigs: Effects of amylose:amylopectin ratio, extrusion, storage duration, and enzyme supplementation. J Anim Sci 93(7):3512-3520. doi:10.2527/jas.2014-8790. https://doi.org/10.2527/jas.2014-8790 

• Loor, J. J., M. Vailati-Riboni, J. C. McCann, Z. Zhou, and M. Bionaz. 2015. TRIENNIAL LACTATION SYMPOSIUM: Nutrigenomics in livestock: Systems biology meets nutrition. J Anim Sci 93(12):5554-5574. doi:10.2527/jas.2015-9225. https://doi.org/10.2527/jas.2015-9225 

• Minuti, A., Z. Zhou, D. E. Graugnard, S. L. Rodriguez-Zas, A. R. Palladino, F. C. Cardoso, E. Trevisi, and J. J. Loor. 2015. Acute mammary and liver transcriptome responses after an intramammary Escherichia coli lipopolysaccharide challenge in postpartal dairy cows. Physiol Rep 3(4). doi:10.14814/phy2.12388. https://doi.org/10.14814/phy2.12388 

• Wang, M., Z. Zhou, M. J. Khan, J. Gao, and J. J. Loor. 2015. Clock circadian regulator (CLOCK) gene network expression patterns in bovine adipose, liver, and mammary gland at 3 time points during the transition from pregnancy into lactation. J Dairy Sci 98(7):4601-4612. doi:10.3168/jds.2015-9430. https://doi.org/10.3168/jds.2015-9430 

• Zhou, Y., Z. Zhou, W. Zhang, X. Hu, H. Wei, J. Peng, and S. Jiang. 2015. SIRT1 inhibits adipogenesis and promotes myogenic differentiation in C3H10T1/2 pluripotent cells by regulating Wnt signaling. Cell & Bioscience 5(1):61. doi:10.1186/s13578-015-0055-5. https://doi.org/10.1186/s13578-015-0055-5 

• Zhou, Z., D. P. Bu, M. Vailati Riboni, M. J. Khan, D. E. Graugnard, J. Luo, F. C. Cardoso, and J. J. Loor. 2015. Prepartal dietary energy level affects peripartal bovine blood neutrophil metabolic, antioxidant, and inflammatory gene expression. J Dairy Sci 98(8):5492-5505. doi:10.3168/jds.2014-8811. https://doi.org/10.3168/jds.2014-8811  

• Zhou, Z., H. F. Wan, Y. Li, W. Chen, Z. L. Qi, P. Peng, and J. Peng. 2010. The influence of the amylopectin/amylose ratio in samples of corn on the true metabolizable energy value for ducks. Animal Feed Science and Technology 157(1):99-103. doi:10.1016/j.anifeedsci.2010.02.005. https://doi.org/10.1016/j.anifeedsci.2010.02.005 

• Luo, H. F., H. K. Wei, F. R. Huang, Z. Zhou, S. W. Jiang, and J. Peng. 2009. The effect of linseed on intramuscular fat content and adipogenesis related genes in skeletal muscle of pigs. Lipids 44(11):999-1010. doi:10.1007/s11745-009-3346-y. https://doi.org/10.1007/s11745-009-3346-y 

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