Publications

Single-Molecule Peptide Sequencing through Reverse Translation of Peptides into DNA

Zheng, L.;* Sun, Y.; Hein, L. A.; Eisenstein, M.; Soh, H. T.*, Nat. Biotechnol. (2026). [Link]

Highlighted in:

• Nature Biotechnology

• C&EN

• Stanford Report

• The Analytical Scientist

Direct Optical Detection of Factor Xa Activity in Minimally Processed Whole Blood

Cartwright, A. P.; Wollant, B. C.; York, E. S.; Zheng, L.; Yee, S.; Chau, H. C.; Batsuli, G.; Soh, H. T., ACS Sens. 2025, 10 (4), 3143–3151.  [Link]

Multiplexed Assay for Small-Molecule Quantification via Photo-Cross-Linking of Structure Switching Aptamers

Newman, S. S.; Wilson, B.; Zheng, L.; Eisenstein, M.; Soh, H. T., ACS Omega 2024, 9 (43), 43785–43792.  [Link]

An Antibody-Based Molecular Switch for Continuous Small-Molecule Biosensing

Thompson, I. A. P.; Saunders, J.; Zheng, L.; Hariri, A. A.; Maganzini, N.; Cartwright, A. P.; Pan, J.; Yee, S.; Dory, C.; Eisenstein, M.; Vuckovic, J.; Soh, H. T.,  Sci. Adv. 2023, 9 (38), eadh4978.  [Link]

A Massively Parallel Screening Platform for Converting Aptamers into Molecular Switches

Yoshikawa, A. M.; Rangel, A. E.; Zheng, L.; Wan, L.; Hein, L. A.; Hariri, A. A.; Eisenstein, M.; Soh, H. T.,  Nat. Commun. 2023, 14 (1), 2336.  [Link]

A System for Multiplexed Selection of Aptamers with Exquisite Specificity without Counterselection

Yoshikawa, A. M.; Wan, L.; Zheng, L.; Eisenstein, M.; Soh, H. T., Proc. Natl. Acad. Sci. 2022, 119 (12), e2119945119.  [Link]

Rational Design of Aptamer Switches with Programmable pH Response

Thompson, I. A. P.; Zheng, L.; Eisenstein, M.; Soh, H. T., Nat. Commun. 2020, 11 (1), 2946. [Link]

Independent Generation and Reactivity of 2′-Deoxyguanosin-N1-yl Radical

Zheng, L.; Greenberg, M. M., J. Org. Chem. 2020, 85 (13), 8665–8672. [Link]

Independent Generation and Time-Resolved Detection of 2′-Deoxyguanosin-N2-yl Radicals

Zheng, L.;† Dai, X.;† Su, H.; Greenberg, M. M., Angew. Chem. Int. Ed. 2020, 59 (32), 13406–13413. [Link]

†Equal contribution. 

Positional Dependence of DNA Hole Transfer Efficiency in Nucleosome Core Particles

Sun, H.; Zheng, L.; Yang, K.; Greenberg, M. M., J. Am. Chem. Soc. 2019, 141 (26), 10154–10158. [Link]

Independent Generation of Reactive Intermediates Leads to an Alternative Mechanism for Strand Damage Induced by Hole Transfer in Poly(dA–T) Sequences

Sun, H.;†  Zheng, L.;† Greenberg, M. M., J. Am. Chem. Soc. 2018, 140 (36), 11308–11316.  [Link]

†Equal contribution.

Traceless Tandem Lesion Formation in DNA from a Nitrogen-Centered Purine Radical

Zheng, L.; Greenberg, M. M., J. Am. Chem. Soc. 2018, 140 (20), 6400–6407. [Link]

DNA Damage Emanating From a Neutral Purine Radical Reveals the Sequence Dependent Convergence of the Direct and Indirect Effects of γ-Radiolysis

Zheng, L.; Greenberg, M. M., J. Am. Chem. Soc. 2017, 139 (49), 17751–17754. [Link]

Independent Photochemical Generation and Reactivity of Nitrogen-Centered Purine Nucleoside Radicals from Hydrazines

Zheng, L.; Lin, L.; Qu, K.; Adhikary, A.; Sevilla, M. D.; Greenberg, M. M. Org. Lett. 2017, 19 (23), 6444–6447. [Link]

Aminyl Radical Generation via Tandem Norrish Type I Photocleavage, β-Fragmentation: Independent Generation and Reactivity of the 2′-Deoxyadenosin- N6-yl Radical

Zheng, L.; Griesser, M.; Pratt, D. A.; Greenberg, M. M., J. Org. Chem. 2017, 82 (7), 3571–3580. [Link]

Covalently Bound Benzyl Ligand Promotes Selective Palladium-Catalyzed Oxidative Esterification of Aldehydes with Alcohols

Liu, C.; Tang, S.; Zheng, L.; Liu, D.; Zhang, H.; Lei, A., Angew. Chem. Int. Ed. 2012, 51 (23), 5662–5666. [Link]

Nickel-Catalyzed Heck-Type Alkenylation of Secondary and Tertiary α-Carbonyl Alkyl Bromides

Liu, C.; Tang, S.; Liu, D.; Yuan, J.; Zheng, L.; Meng, L.; Lei, A., Angew. Chem. Int. Ed. 2012, 51 (15), 3638–3641. [Link]