Publications

Publications:

Self-archived early-view manuscripts

PEER-REVIEWED JOURNAL PUBLICATIONS:   (* corresponding, # equal contribution)

2025

18. K. Mohn, B. Dong, S. Mahapatra, I.K. Singh, J.P. Lomont, B. Wan, and C. Zhang*. "Spontaneous or Stimulated? Investigating Raman’s Detection Limits in Aqueous Environments". Journal of Physical Chemistry B, 129, 37, 9446–9456 (2025). Link

17. B. Dong, R. M. Everly, S. Mahapatra, M. S. Carlsen, S. Ma, and C. Zhang*. "Spatially and Chemically Specific Optical Control of Cells via Supervised and Automated Target Selection". ACS Photonics, 12, 3421–3434 (2025) Link

16. S. Mahapatra, S.B. Shivpuje, H.C. Campbell, B. Wan, J. Lomont, B. Dong, S. Ma, K.J. Mohn, and C. Zhang*. "Label-Free Quantification of Apoptosis and Necrosis Using Stimulated Raman Scattering Microscopy". Analytical Chemistry, 97, 13256–13265 (2025) Link

15. P. Prakash, et al. M.G. Clark, B. Dong, S. Ma, et al. C. Zhang, D. Davalos*, and G. Chopra*. "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease". Immunity. 58, 1536-1552 (2025) Link 

14. S. Ma, B. Dong, M.G. Clark, R.M. Everly, S. Mahapatra, and C. Zhang*. "Real-Time and Site-Specific Perturbation of Dynamic Subcellular Compartments Using Femtosecond Pulses". Small Science, 2500166 (2025). Link  (Front Cover)

13. C. Zhang*, B. Dong, S. Mahapatra, S. Ma. "Advances and Future Trends in Real-Time Precision Opto-Control (RPOC) of Chemical Processes in Live Cells". (Review) npj Imaging, 3, 23 (2025). Link

12. G. Gonzalez, E. Osuji, N. Fiur, M. Clark, S. Ma, L. Lukov, and C. Zhang*. "Alteration of lipid metabolism in hypoxic cancer cells". Chemical & Biomedical Imaging, 3, 25-34 (2025). Link (Supplementary Cover)

2024

11. J.J. Chen, J.F. Markworth, C. Ferreira, C. Zhang, and S. Kuang*. "Lipid droplet as a cell fate determinant in skeletal muscle". (Review) Trends in Endocrinology and Metabolism, (2024) In Press. Link

10. S. Mahapatra, S. Ma, B. Dong, and C. Zhang*. "Quantification of cellular phototoxicity of organelle stains by the dynamics of microtubule polymerization" VIEW, 20240013 (2024). Link

9. M.G. Clark, K.J. Mohn, B. Dong, H.C. Campbell, and C. Zhang*. "Frequency-domain low-wavenumber hyperspectral stimulated Raman scattering microscopy", Analytical Chemistry, 96 (25) 10341–10347 (2024). Link (Supplementary Cover)

8. J. Zhang, H. Lin, J. Xu*, M Zhang, X. Ge, C. Zhang, W. E. Huang*, and J. X. Cheng*. "High-throughput single-cell sorting by stimulated Raman-activated cell ejection", Science Advances, 10, eadp2438 (2024). Link

7. B. Dong#, S. Mahapatra#, M.G. Clark, et al. and C. Zhang*. "Spatiotemporal precise optical manipulation of intracellular molecular activities", Advanced Science, 2307342 (2024). Link

2023

6. C. Zhang*. “Coherent Raman scattering microscopy of lipid droplets in cells and tissues”, (Review) Journal of Raman Spectroscopy. 54, 988-1000 (2023).  Link

5. M.G. Clark, S. Ma, S. Mahapatra, K. Mohn, and C. Zhang*. "Chemical-imaging-guided optical manipulation of biomolecules", (Perspective) Frontiers in Chemistry. 11:1198670 (2023). Link

2022

4. M.G. Clark, G. Gonzalez, and C. Zhang*. "Pulse-picking multimodal nonlinear optical microscopy". Analytical Chemistry 94, 15405–15414 (2022). Link

3. M.G. Clark, G. Gonzalez, Y. Luo, J. Aldana-Mendoza, M.S. Carlsen, G. Eakins, M. Dai, and C. Zhang*. "Real-time precision opto-control of chemical processes in live cells". Nature Communications, 13, 4343 (2022). Link

2. M.G. Clark, K. Brasseale, G. Gonzalez, G. Eakins, and C. Zhang*. "Direct comparison of hyperspectral stimulated Raman scattering and coherent anti-Stokes Raman scattering microscopy for chemical imaging", Journal of Visualized Experiments 182, e63677 (2022). Link

2021

1. C. Zhang* and J. A. Aldana-Mendoza. "Coherent Raman scattering microscopy for chemical imaging of biological systems", (Review) Journal of Physics, Photonics 3, 032002 (2021) Link

BOOK CHAPTERS:

C. Zhang* "Chapter 15. SRS flow and image cytometry", Stimulated Raman Scattering Microscopy. Elsevier, 1st Edition - December 4, 2021

Before Joining Purdue

1. R.A. Carlos, J. Park, C. Zhang, J.E. Sorrells, R.R. Lyer, K.F. Tehrani, A. De la Cadena, S.A. Boppart*. “Large field-of-view metabolic profiling of murine brain tissue following morphine incubation using label-free multiphoton microscopy”. J. Neuro. Methods, 405, 110171 (2024).

2. C. Zhang, F. R. Zaki, J. Won, and S. A. Boppart*. "A multimodal nonlinear optical microscopy study of the responses of Pseudomonas aeruginosa to blue light and antibiotic treatment", J. BioPhotonics, e202300384. (2023)

3. W. Zhou; P. VanDuyne; C. Zhang; Y. Liu; R. Riessen; M. Barragan; B. M. Rowitz; M. Teran-Garcia; S. A. Boppart; S. Anakk*. "Pathological bile acid concentrations in chronic cholestasis cause adipose mitochondrial defects ", JHEP Reports, 5, 100714. (2023)

4. P. Mukherjee, E. Aksamitiene, A. Alex, J. Shi, K. Bera, C. Zhang, D. Spillman, M. Marjanovic, M. Fazio, P.P. Seth, K. Frazier, S.R. Hood, and S.A. Boppart*. "Differential Uptake of Antisense Oligonucleotides in Mouse Hepatocytes and Macrophages Revealed by Simultaneous Two-Photon Excited Fluorescence and Coherent Raman Imaging", Nucleic Acid Ther., 32, 163-176 (2022) 

5. C. Zhang and S. A. Boppart*. "Tracking the formation and degradation of fatty-acid-accumulated mitochondria using label-free chemical imaging", Sci. Rep. 11, 6671 (2021) Link

6. C. Zong, C. Zhang, P. Lin, J. Yin, Y. Bai, H. Lin, B. Ren*, and J. Cheng*. "Real-time imaging of surface chemical reactions by electrochemical photothermal reflectance microscopy", Chem. Sci., 12, 1930-1936 (2021) Link

7. C. Zhang and S. A. Boppart*. "Dynamic signatures of lipid droplets as new markers to quantify cellular metabolic changes", Anal. Chem., 92, 15943–15952 (2020). Link 

8. K. Huang#, J. Li#, C. Zhang#, Y. Tan, J.X. Cheng*. “Multiplex stimulated Raman scattering imaging cytometry reveals cancer metabolic signatures in a spatially and spectrally resolved manner”, iScience, 23, 100953, (2020).

9. C. Zong, R. Premasiri, H. Lin, Y. Huang, C. Zhang, C. Yang, B. Ren, L.D. Ziegler, J.X. Cheng*. “Plasmon-enhanced stimulated Raman scattering microscopy with Single-molecule detection sensitivity”, Nat. Commun., 10, 5318, (2019).

10. J.H. Lee#, J.J. Rico-Jimenez#, C. Zhang, A. Alex, E.J. Chaney, R. Barkalifa, D.R. Spillman, M. Marjanovic, Z. Arp, S.R. Hood, and S.A. Boppart*. “Simultaneous label-free autofluorescence and multi-harmonic imaging reveals in vivo structural and metabolic changes in murine skin”, Biomed. Opt. Express, 10, 5421-5444 (2019).

11. X. Chen*, S.P. Zhu, H.Y. Wang, C.P. Bao, D.F. Yang, C. Zhang, P. Lin, J.X. Cheng, Y.H. Zhan, J.M. Liang, and J. Tian*. “Accelerated stimulated Raman projection tomography by sparse reconstruction from sparse-view data”, IEEE Trans. Biomed. Eng., 10.1109/TBME.2019.2935301 (2019).

12. Y. Sun, H. Tu, S. You, C. Zhang, Y. Liu, and S.A. Boppart*. “Detection of weak near-infrared optical imaging signals under ambient light by optical parametric amplification”, Opt. Lett., 17, 4391-4394, (2019).

13. C. Zhang, J.X. Cheng*, “Coherent Raman scattering imaging: the future is bright”, Appl. Phys. Lett. Photonics, 3, 090901 (2018).

14. Y. Urasaki#, C. Zhang#, J.X. Cheng, T.T. Le, “Quantitative assessment of liver steatosis and affected pathways with molecular imaging and proteomic profiling”, Sci. Rep., 8, 3606, (2018).

15. C. Zhang#, J. Li#, L. Lan, and J.X. Cheng* “Quantification of lipid metabolism through the dynamics of lipid droplets in living cells by stimulated Raman scattering imaging”, Anal. Chem., 89, 4502-4507, (2017).

16. X. Chen#, C. Zhang#, P. Lin, K. Huang, J. Liang, J. Tian, and J.X. Cheng* “Volumetric chemical imaging by stimulated Raman projection microscopy and tomography”, Nat. Commun., 8, 15117, (2017).

17. C. Zhang* “Sum frequency generation vibrational spectroscopy for characterization of buried polymer interfaces” Focal Point Review, Appl. Spectrosc., 71, 1717-1749 (2017).

18. C. Zhang#, K. Huang#, B. Rajwa, J. Li, S. Yang, H. Lin, C. Liao, G. Eakins, S. Kuang, V. Patsekin, J.P. Robinson, J.X. Cheng* “Label-free single-particle analysis by stimulated Raman scattering flow cytometry”, Optica, 4, 103-109 (2017).

19. X. Lu*, C. Zhang, Z. Chen* “Studying polymer surfaces and interfaces with sum frequency generation vibrational spectroscopy”, Anal. Chem., 89, 466-489 (2016).

20. D. Zhang, C. Li, C. Zhang, M. N. Slipchenko, G. Eakins, J.X. Cheng*, “Depth-resolved mid-infrared photothermal imaging of living cells and organisms with sub-micro spatial resolution”, Sci. Adv., 2, e1600521. (2016).  

21. J. Jasensky, A. Boughton, A. Khamaladze, J. Ding, C. Zhang, J. Swain, G. Smith, Z. Chen*, G. Smith*, “Live-cell quantification and comparison of mammalian oocyte cytosolic lipid content between species during development, and in relation to body composition using nonlinear vibrational microscopy”, Analyst, 141, 4694-4706 (2016).

22. C. Zhang, D. Zhang, J. Cheng*, “Coherent Raman scattering microscopy in biology and medicine”, Annu. Rev. Biomed. Eng., 17, 415-445 (2015).

23. C. Zhang*, J. Jasensky, Z. Chen*, “Multi-reflection sum frequency generation vibrational spectroscopy”, Anal. Chem., 87, 8157-8164 (2015).

24. C. Zhang*, J. Wang, J. Jasensky, Z. Chen, “Molecular orientation analysis of alkyl methylene groups from quantitative coherent anti-Stokes Raman scattering spectroscopy”, J. Phys. Chem. Lett., 6, 1369-1374 (2015).

25. P. Hu, X. Zhang, C. Zhang, Z. Chen*, “Molecular interactions between gold nanoparticles and model cell membranes”, Phys. Chem. Chem. Phys., 17, 9873-9884 (2015).

26. A. Khmaladze*, J. Jasensky, E. Price, C. Zhang, A. Boughton, X. Han, E. Seeley, X. Lu, M. M. Banaszak Holl, Z. Chen*, “Hyperspectral imaging and characterization of live cells by broadband coherent anti-Stokes Raman scattering (CARS) microscopy with singular value decomposition (SVD) analysis”, Appl. Spectrosc., 68, 1116-1122 (2014).

27. F-G Wu*, P. Yang, C. Zhang, B. Li, X. Han, M. Song, and Z. Chen*, “Molecular interactions between amantadine and model cell membranes”, Langmuir, 30, 8491-8499 (2014).

28. F-G Wu*, P. Yang, C. Zhang, X. Han, M. Song, and Z. Chen*, “Investigation of drug–model cell membrane interactions using sum frequency generation vibrational spectroscopy: a case study of chlorpromazine”, J. Phys. Chem. C, 118, 17538-17548 (2014).

29. C. Zhang*, J. Wang, B. Ding, J. Jasensky, “Quantitative spectral analysis of coherent anti-Stokes Raman scattering signal: C-H stretching modes of the methyl group”, J. Phys. Chem. B, 118, 7647-7656 (2014). 

30. C. Zhang, J. Jasensky, C. Leng, C. Del Grosso, G. D. Smith, J. Wilker and Z. Chen*, “Sum frequency generation vibrational spectroscopic studies on buried heterogeneous biointerfaces”, Opt. Lett., 39, 2715-2718 (2014).

31. J. Myers, C. Zhang, C. Chen, Z. Chen*, “Influence of casting solvent on Phenyl ordering at the surface of spin cast polymer thin films”, J. Colloid Interface Sci., 423, 60-66 (2014).

32. J. Myers, C. Zhang, K.W. Lee, J.M. Williamson, Z. Chen*, “Hygrothermal aging effects on buried molecular structures at epoxy interfaces”, Langmuir, 30, 165-171 (2014).

33. C. Zhang, J. Myers, Z. Chen*, “Molecular behavior at buried epoxy/poly(ethylene terephthalate) interfaces”, Langmuir, 30, 12541-12550 (2014).

34. C. Zhang, F. Wu, P. Hu, Z. Chen*, “Interaction of polyethylenimine with model cell membranes studied by linear and nonlinear spectroscopic techniques”, J. Phys. Chem. C, 118, 12195-12205 (2014).

35. X. Zhang, C. Zhang, J. Hankett, Z. Chen*, "Molecular surface structural changes of plasticized PVC materials after plasma treatment", Langmuir, 29, 4008-4018 (2013).

36. J. M. Hankett, Y. Liu, X. Zhang, C. Zhang, Z. Chen*, "Molecular level studies of polymer behaviors at the water interface using sum frequency generation vibrational spectroscopy", J. Polym. Sci. Part B Polym. Phys., 51, 311-328 (2013).

37. C. Zhang, J. Myers, Z. Chen*, "Elucidation of molecular structures at buried polymer interfaces and biological interfaces using sum frequency generation vibrational spectroscopy", Soft Matter, 9, 4738-4761 (2013).  

38. C. Zhang, Z. Chen*, "Quantitative molecular level understanding of ethoxysilane at poly(dimethyl siloxane)/polymer interfaces", Langmuir, 29, 610-619 (2013).

39. C. Zhang, Z. Chen*, "Probing molecular structures of poly(dimethyl siloxane) at buried interfaces in situ", J. Phys. Chem. C, 117, 3903-3914 (2013).

40. C. Zhang, J. Hankett, Z, Chen*, "Molecular level understanding of adhesion mechanisms at the epoxy/polymer interfaces", ACS Appl. Mater. Interfaces, 4, 3730-3737 (2012).

41. C. Zhang, N. E. Shephard, S. M. Rhodes, Z. Chen*, "Head group effect on silane structures at polymer/silane and polymer/polymer interfaces and their relations to adhesion", Langmuir, 28, 6052-6059 (2012).

42. J. M. Hankett, C. Zhang, Z. Chen*, "Sum frequency generation and coherent anti-Stokes Raman spectroscopic studies on plasma-treated plasticized polyvinyl chloride films", Langmuir, 28, 4654-4662 (2012).

43. C. Zhang, Y.Y. Zhang, M.L. Hu*, S.J. Wang, Y.J. Song, L. Chai, C.Y. Wang, "Wavelength tunable, high energy femtosecond laser pulses directly generated from large-mode-area photonic crystal fiber", Opt. Commun., 285, 2715-2718 (2012).

44. C. Zhang*, J. Wang, A. Khmaladze, Y. Liu, B. Ding, J. Jasensky, Z. Chen, "Examining surface and bulk structures using combined nonlinear vibrational spectroscopies", Opt. Lett., 36, 2272-2274 (2011).

45. A. Khmaladze*, R. L. Matz, C. Zhang, T. Wang, M. M. Banaszak Holl, Z. Chen, "Dual-wavelength linear regression phase unwrapping in three-dimensional microscopic images of cancer cells", Opt. Lett., 36, 912-914 (2011).

46. Y.Y. Zhang, C. Zhang, M.L. Hu*, Y.J. Song, S.J. Wang, L. Chai, and C.Y. Wang, "High-energy subpicosecond pulse generation from a mode-locked Yb-doped large-mode-area photonic crystal fiber laser with fiber facet output", IEEE Photonics Technol. Lett., 22, 350-352 (2010).

47. Y.Y. Zhang, C. Zhang, M.L. Hu*, S.J. Wang, Y.J. Song, L. Chai, C.Y. Wang, "Mechanism and elimination of spectrum filtering in a high power mode-locked fibre laser with a free output coupler", Chin. Phys. B, 19: 014212 (2010).

48. C. Zhang, M.L. Hu*, Y. Song, X. Zhang, L. Chai, C.Y. Wang, "An Yb-doped large-mode-area photonic crystal fiber mode-locking laser with free output coupler", Acta. Phys. Sin., 58, 7727-7734 (2009).

49. Y.J. Song, M.L. Hu*, C. Zhang, L. Chai, C.Y. Wang, "High pulse energy femtosecond large-mode-area photonic crystal fiber laser", Chin. Sci. Bull., 53, 3741-3745 (2008).

PUBLICATION LINK:

https://scholar.google.com/citations?user=Ahxte2kAAAAJ&hl=en