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We play with photons
We develop novel optical spectroscopy, imaging, and opto-control technologies and apply them to study chemistry in living samples. We use chemical imaging to answer questions in biological and medical sciences and develop new opto-control platforms to precisely control chemical processes in live cells.
Group News
Group News
06/13/2025
Congratulations to Shivam for receiving the 2nd prize for the poster presentation at the MAGSS conference!
06/06/2025
Our paper on SRS imaging of cell death, in collaboration with Merck, has been accepted for publication by Anal. Chem. Congratulations to Shivam and Shreya, co-first authors.
05/28/2025
Our review paper, "Advances and Future Trends in Real-Time Precision Opto-Control (RPOC) of Chemical Processes in Live Cells" is published in npj Imaging!
05/19/2025
Seohee Ma has received the Alice Watson Kramer award with a $500 monetary award! Congratulations!
Ishaan Singh has received a $15000 Astronaut Scholarship! Congratulations!
05/15/2025
Shivam and Ishaan presented posters at the 10th Annual Hitchhiker's Guide to the Biomolecular Galaxy 2025!
05/14/2025
Helen obtained her M.S. degree in Chemistry from Purdue. Congratulations!
04/27/2025
Congratulations to Seohee and coauthors for accepting the femtosecond RPOC paper by Small Science.
04/22/2025
Jesse attended the Optica Biophotonics Congress in San Diego and presented RPOC and SRS.
04/10/2025
Shivam and Karsten presented posters at the CLUMB symposium hosted by UIUC.
04/03/2025
Congratulations to Karsten on winning the 3-minute thesis presentation at the CBM symposium!
03/25/2025
Shreya has found a data analyst position at CVS in New York. Congratulations!
02/05/2025
Nikta Zafarjafarzadeh joined our group. Welcome! Nikta transferred from the Biochem department to our Chemistry Department. She is interested in working with cancer metabolism!
1/30/2025
Bin, Shivam, Seohee, Karsten, and Jesse attended SPIE Photonics West. We presented 12 presentations, including 7 oral presentations, 1 three-minute challenge, and 4 posters. Congratulations to Shivam on receiving the best poster award in BO400, and second place in the 3MT presentation! Bin, Shivam, and Seohee have also received Travel grants from Purdue University!
1/14/2025
Xinyi He joined our group! Welcome. Xinyi is a M.S. student from BME department!
Selected publications
B. Dong#, S. Mahapatra#, M.G. Clark, et al. and C. Zhang*. "Spatiotemporal precise optical manipulation of intracellular molecular activities", Advanced Science, 2307342 (2024) Link
M.G. Clark, G. Gonzalez, Y. Luo, J. Aldana-Mendoza, M.S. Carlsen, G. Eakins, M. Dai, and C. Zhang*. "Real-time precision opto-control of chemical processes in live cells". Nature Communications, 13, 4343 (2022). Link
M.G. Clark, K.J. Mohn, B. Dong, H.C. Campbell, and C. Zhang*. "Frequency-domain low-wavenumber hyperspectral stimulated Raman scattering microscopy", Analytical Chemistry, (2024) 96 (25) 10341–10347. Link
M.G. Clark, G. Gonzalez, and C. Zhang*. "Pulse-picking multimodal nonlinear optical microscopy". Analytical Chemistry 94, 15405–15414 (2022). Link
S. Mahapatra, S. Ma, B. Dong, and C. Zhang*. "Quantification of cellular phototoxicity of organelle stains by the dynamics of microtubule polymerization" VIEW, 20240013 (2024). Link
G. Gonzalez, E. Osuji, N. Fiur, M. Clark, S. Ma, L. Lukov, and C. Zhang*. "Alternation of lipid metabolism in hypoxia cancer cells". Chemical & Biomedical Imaging, (2024) In Press. Link
Lab address:
BRWN 4175, 4175A, 4174, 4174A
560 Oval Dr.
West Lafayette
IN, 47907, USA
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