Publications

For a complete list of publications: pubmed.

Editorial and/or theoretical manuscripts

2024:

Major proposal: A revision for the criteria for gasotransmitters is proposed so that oxygen can be considered as an 'essential gasotransmitter'. Oxygen is proposed as a gasocrine signal between oxygen-producing organisms and animals. In this manuscript, the term and definition for 'gasocrinology' is proposed for the first time in an English language-based scientific society journal. Androglobin is also proposed as one of the putative oxygen-sensing receptor. 

Major proposal: A hypothesis is proposed that putative aquareceptor candidates could be some of the heme-based oxygen-sensing gasoreceptors in which water can bind at oxygen-binding sites. In this manuscript, the term and definition for 'protein aquareceptor' are proposed for the first time in a (biochemical society) journal. 

For english-language manuscript, a preprint is available here. 

Major proposal: A hypothesis is proposed that putative gas-sensing ribocepter candidates could be some of the G4 heme-based nucleic acid structures with catalytic activity. In this manuscript, the term and definition for 'riboceptor' are proposed for the first time in a scientific journal. 

For readers without a subscription to the journal, a preprint of the manuscript draft is available here. 

Major proposal: A hypothesis is proposed that putative temperature-sensing riboceptor candidates could be some of the temperature-sensitive nucleic acid structures with catalytic activity. In this manuscript, the term 'thermocrine signaling' is proposed for the first time to include all temperature-based signaling events triggered via temperature-sensing receptors.

For readers without a subscription to the journal, a preprint of the manuscript draft is available here. 

Other manuscripts

Selected publications:

2023:

Anbalagan S. Animal Model Exp Med. 2023. doi: 10.1002/ame2.12364. 

The big question asked: Are we ready to replace animal model organisms with other nonanimal model systems? 

Major findings: Yes and NO.  Several arguments about the limitations of nonanimal model systems including the AI-tools in drug discovery are highlighted.

Chodkowski M, Zielezinski A, Anbalagan S. iScience. 2023. doi: 10.1016/j.isci.2023.107309.

The big question asked: There are human and mice protein ligand-receptor atlases and tools to identify ligand-receptor pairs, why there is none for zebrafish?
Major findings: We provide the zebrafish research community with a deep learning-based prediction of cellular localization of the zebrafish proteome, ligand-receptor interactions (based on zebrafish and its interologs protein-protein interactions), and open-source scripts (Github: DanioTalk) to identify such pairs in -omics datasets.

Swaminathan A, Gliksberg M, Anbalagan S, Wigoda N, Levkowitz G. Cell Rep. 2023. doi: 10.1016/j.celrep.2022.111973. 

The big question asked in this research collaboration: Why some animals are susceptible to stress while others are resilient to stress? Is there a genetic component to stress resilience in zebrafish?
Major findings: There are genetic components to stress resilience also in zebrafish. And our data suggest it to be dependent on proteins that are well known for their roles in the immune system. 

2021:

Anbalagan S. J Neuroendocrinol. 2021. doi: 10.1111/jne.12924.

The big question asked: How many different endocrine signaling can occur between non-host factors such as the gut microbiome and glial cells? and are those signaling important for animal development or disease ontology?
Major findings: Multiple research works support the importance of such endocrine interactions. In addition, in this manuscript, the term 'gasocrine' is coined for the first time in English language-based scientific society journal.

2019:

Anbalagan S, Blechman J, Gliksberg M, Gordon L, Rotkopf R, Dadosh T, Shimoni E, Levkowitz G. Elife. 2019. doi: 10.7554/eLife.45650.

2018:

Anbalagan S, Gordon L, Blechman J, Matsuoka RL, Rajamannar P, Wircer E, Biran J, Reuveny A, Leshkowitz D, Stainier DYR, Levkowitz G.

Dev Cell. 2018. doi: 10.1016/j.devcel.2018.10.017.

Blechman J, Anbalagan S, Matthews GG, Levkowitz G. Front Cell Dev Biol. 2018. doi: 10.3389/fcell.2018.00117. 

Preprints

For a complete list of preprints: bioRxiv ; OSF Preprints ; Zenodo.

Preprints in preparation:

Selected preprints:

2024:

2023: