Publications

Preprints *corresponding author; #equal contribution

5. Rio Tsutsumi, Antoine Nicolas Diez, Steffen Plunder, Ryuichi Kimura, Shinya Oki, Kaori Takizawa, Haruhiko Akiyama, Yusuke Mii, Ritsuko Takada, Shinji Takada, Mototsugu Eiraku
Self-organized fingering instabilities drive the emergence of tissue morphogenesis in digit organoids.
bioRxiv (2025) https://www.biorxiv.org/content/10.1101/2025.08.31.673315v1

4. Takafumi Ikeda, Toru Kawanishi, Yusuke Mii, Taijiro Yabe, Jose Pelliccia, Rebecca D Burdine, Hiroyuki Takeda
Differential spreading behaviors of Nodal signalling molecules in the extracellular space cooperatively shape left-right asymmetry
bioRxiv (2025) https://www.biorxiv.org/content/10.1101/2025.08.13.670121v1

3. Minako Suzuki, Ritsuko Takada, Tomoe Kobayashi, Makoto Matsuyama, Shinji Takada, Yusuke Mii*

Dynamic polarization of heparan sulfate proteoglycans is involved in planar cell polarity and localization of endogenous Wnt11 during vertebrate neural tube formation.

bioRxiv (2025) https://www.biorxiv.org/content/10.1101/2025.08.12.669988v1

2. Yusuke Mii*#, Minako Suzuki#, Hiroshi Koyama, Kei Nakayama, Ritsuko Takada, Tomoe Kobayashi, Motosuke Tsutsumi, Tomomi Nemoto, Makoto Matsuyama, Toshihiko Fujimori, and Shinji Takada*
Emergence of cell polarity by reciprocal interactions between Wnt and core PCP components.

bioRxiv (2025) https://www.biorxiv.org/content/10.1101/2025.08.11.669788v1

1. Takayoshi Yamamoto, Yusuke Mii, Hidetoshi Saiga, Tatsuo Michiue, Masanori Taira

Identification of N-acetyl-rich heparan sulfate binding motifs and their role in expanding BMP distribution and signaling by Cerberus

bioRxiv (2025) https://www.biorxiv.org/content/10.1101/2025.04.16.649141v1

Original Papers (peer-reviewed) *corresponding author; #equal contribution

14. Minako Suzuki, Shinji Takada, *Yusuke Mii

Dissection of N-deacetylase and N-sulfotransferase activities of NDST1 and their effects on Wnt8 distribution and signaling in Xenopus embryos

Dev. Growth Differ. 66 (3) 248-255. (2024)

https://doi.org/10.1111/dgd.12915

13. #Thi Hong Nguyen Tran, #Ritsuko Takada, Elena Krayukhina, Takahiro Maruno, Yusuke Mii, Susumu Uchiyama, and *Shinji Takada

Soluble Frizzled-related proteins promote exosome-mediated Wnt re-secretion

Communications Biology 7:254 (2024)

12. Atsushi Takahashi-Kanemitsu, Mengxue Lu, Christopher Takaya Knight, Takayoshi Yamamoto, Takuo Hayashi, Yusuke Mii, Takuya Ooki, Ippei Kikuchi, Akira Kikuchi, Nick Barker, Etsuo A Susaki, Masanori Taira, *Masanori Hatakeyama

The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells

Science Signaling 16, eabp9020 (2023)

11. Yudai Hatakeyama, *Nen Saito, Yusuke Mii, Ritsuko Takada, Takuma Shinozuka, Tatsuya Takemoto Honda Naoki, *Shinji Takada

Intercellular exchange of Wnt ligands reduces cell population heterogeneity during embryogenesis

Nature Communications 14:1924 (2023)

10. Sayuki Hirano, Yusuke Mii, Guillaume Charras, *Tatsuo Michiue

Alignment of cell long axis by unidirectional tension acts cooperatively with Wnt signalling to establish PCP.

Development 149 (12): dev200515. (2022)

9. Kei Yamamoto, Haruko Miura, Motohiko Ishida, Yusuke Mii, Noriyuki Kinoshita, Shinji Takada, Naoto Ueno, Satoshi Sawai, *Yohei Kondo, *Kazuhiro Aoki

Optogenetic relaxation of actomyosin contractility uncovers mechanistic roles of cortical tension during cytokinesis

Nature Communications 12:7145 (2021)

8. *Shinya Matsuda, Jonas V. Schaefer, Yusuke Mii, Yutaro Hori, Dimitri Bieli, Masanori Taira, Andreas Plückthun, *Markus Affolter

Asymmetric requirement of Dpp/BMP morphogen dispersal in the Drosophila wing disc

Nature Communications 12:6435 (2021)

7. *Yusuke Mii, Kenichi Nakazato, Chan-Gi Pack, Takafumi Ikeda, Yasushi Sako, Atsushi Mochizuki, *Masanori Taira, *Shinji Takada

Quantitative analyses reveal extracellular dynamics of Wnt ligands in Xenopus embryos.

eLife 10:e55108 (2021)

6. Di Feng, Jin Wang, Wei Yang, Jingyu Li Xiaochen Lin, Fangzi Zha, Xiaolu Wang, Luyao Ma, Nga Ting Choi, Yusuke Mii, Shinji Takada, Michael S.Y. Huen, Yusong Guo, Liang, Zhang, *Bo Gao

Regulation of Wnt/PCP Signaling through p97/VCP-KBTBD7-mediated Vangl Ubiquitination and Endoplasmic Reticulum-Associated Degradation.

Science Advances 7:eabg2099 (2021)

5. Youichi Uda, Haruko Miura, Yuhei Goto, Kei Yamamoto, Yusuke Mii, Yohei Kondo, Shinji Takada, and *Kazuhiro Aoki

Improvement of Phycocyanobilin Synthesis for Genetically Encoded Phytochrome-Based Optogenetics

ACS Chem. Biol. 15, 2896-2906 (2020)

4. #Ritsuko Takada, #Yusuke Mii, Elena Krayukhina, Yuusuke Maruyama, Kazuhiro Mio, Yoshikazu Sasaki, Takao Shinkawa, Chan-Gi Pack, Yasushi Sako, *Chikara Sato, *Susumu Uchiyama, *Shinji Takada

Assembly of protein complexes restricts diffusion of Wnt3a proteins.

Communications Biology 1:165 (2018)

3. Yoshihiro Tsuchiya, Yusuke Mii, Kazunori Okada, Mikio Furuse, Tadashi Okubo, *Shinji Takada

Ripply3 is required for the maintenance of epithelial sheets in the morphogenesis of pharyngeal pouches

Dev. Growth Differ. 60, 87-96 (2018)

2. #Yusuke Mii, #Takayoshi Yamamoto, Ritsuko Takada, Shuji Mizumoto, Makoto Matsuyama, Shuhei Yamada, *Shinji Takada, *Masanori Taira

Roles of two types of heparan sulfate clusters in Wnt distribution and signaling in Xenopus.

Nature Communications 8:1973 (2017)

1. Yusuke Mii, *Masanori Taira

Secreted Frizzled-related proteins enhance the diffusion of Wnt ligands and expand their signalling range.

Development 136, 4083-4088 (2009)