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Ongoing Projects
Ongoing Projects
Quantitative understanding of dynamic cell proliferation control during intestinal stem cell differentiation
Quantitative understanding of dynamic cell proliferation control during intestinal stem cell differentiation
We are investigating the coordinated regulation of cell proliferation and differentiation in the intestinal epithelium, using in-vivo mouse models as well as organoid models. In particular, we use multiplexed imaging, automated high-throughput analyses, and mathematical modeling of intestinal epithelial cell signaling to elucidate mechanisms of cell cycle control during differentiation.
We are investigating the coordinated regulation of cell proliferation and differentiation in the intestinal epithelium, using in-vivo mouse models as well as organoid models. In particular, we use multiplexed imaging, automated high-throughput analyses, and mathematical modeling of intestinal epithelial cell signaling to elucidate mechanisms of cell cycle control during differentiation.
Development of fluorescent live-cell reporters using machine learning algorithms for protein structure prediction
Development of fluorescent live-cell reporters using machine learning algorithms for protein structure prediction
We are developing live-cell fluorescent reporters to measure the dynamics of protein kinase activity, which regulates cell proliferation and differentiation in the intestinal epithelium. A rational pipeline combines molecular and structural biology approaches and uses machine learning algorithms for protein structure prediction to optimize reporter dynamics.
We are developing live-cell fluorescent reporters to measure the dynamics of protein kinase activity, which regulates cell proliferation and differentiation in the intestinal epithelium. A rational pipeline combines molecular and structural biology approaches and uses machine learning algorithms for protein structure prediction to optimize reporter dynamics.
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