Viruses cannot replicate on their own—they must hijack the molecular machinery of the cells they infect. Our laboratory seeks to uncover the cellular factors that determine whether viral infection succeeds or fails.
Using genome-scale functional genomics approaches, we systematically identify host genes required for viral entry, replication, and spread. We then combine molecular virology, cell biology, and advanced in vitro and in vivo models to understand how viruses exploit these host pathways and how cells defend themselves against infection.
Our work focuses on medically important RNA viruses, particularly emerging pathogens that threaten both local and global health. By uncovering fundamental mechanisms of virus–host interactions, we aim to reveal shared vulnerabilities that may be targeted for antiviral strategies and future pandemic preparedness.