Druggable genome screens identify SPP as an antiviral host target for multiple flaviviruses
Qiao W, Xie X, Shi PY, ^^Ooi YS & ^^Carette JE
(2025) PNAS 

MFSD6 is an entry receptor for enterovirus D68
Varanese L, Xu L, Peters CE, Pintilie G, Roberts DS, Raj S, Liu M, Ooi YS, et al.
(2025) Nature

SAMD9 senses cytosolic double-stranded nucleic acids in epithelial and mesenchymal cells to induce antiviral immunity

Hou G, Beatty W, Ren L, Ooi YS, et al.
(2025) Nature Communications 

GeneRaMeN enables integration, comparison, and meta-analysis of multiple ranked gene lists to identify consensus, unique, and correlated genes                                      

Yousefi, M, See WR, Aw-Yong KL, Lee WS, Yong CL, Fanusi F, Smith GJD, Ooi EE, Li S, Ghosh S and Ooi YS

(2024) Briefings in Bioinformatics 

Betacoronaviruses SARS-CoV-2 and HCoV-OC43 infections in IGROV-1 cell line require aryl hydrocarbon receptor                                       

**Yousefi, M, **Lee, WS, **Chan, WOY, He, W, Mah, MG, Yong, CL, Deerain, JM, Wang, L,Arcinas, C, Yan, B, Tan, D, Sia, WR, Gamage, AM, Yang, J, Hsu, ACY, Li, S, Linster, M, Yang, X, Ghosh, S, Anderson, DE, ^^Smith, GJD, ^^Tan, CW, ^^Wang LF, and ^^Ooi YS

(2023) Emerging Microbes & Infections

A fast-growing dengue virus mutant reveals a dual role of STING in response to infection.

Ng WC, Kwek SS, Sun B, Yousefi M, Ong EZ, Tan HC, Puschnik AS, Chan KR, ^^Ooi YS, and ^^Ooi EE. 

(2022) Open Biology

The human disease gene LYSET is essential for lysosomal enzyme transport and viral Infection. 

*Richards CM, *Jabs S, *Qiao W, Varanese LD, Schweizer M, Mosen PR, Riley NM, Klüssendorf M, Zengel JR, Flynn RA, Rustagi A, Widen JC, Peters CE, Ooi YS et al. 

(2022) Science

TMEM41B and VMP1 modulate cellular lipid and energy metabolism for facilitating dengue virus infection. 

Yousefi M, Lee WS, Yan B, Cui L, Yong CL, Yap X, Tay KSL, Qiao W, Tan D, Nurazmi NI, Linster M, Smith GJD, Lee YH, Carette JE, ^^Ooi EE, ^^Chan KR, and ^^Ooi YS. 

(2022) PLoS Pathogens 

Loquacious modulates flaviviral RNA replication in mosquito cells.

Shivaprasad S, Weng KF, Ooi YS et al. 

(2022) PLoS Pathogens 

Inhibitor of growth protein 3 epigenetically silences endogenous retroviral elements and prevents innate immune activation. 

Song Y, Hou G, Diep J, Ooi YS et al. 

(2021) Nucleic Acids Research 

A memory of eS25 loss drives resistance phenotypes.

Johnson AG, Flynn RA, Lapointe CP, Ooi YS et al. 

(2020) Nucleic Acids Research 

Enterovirus Pathogenesis Requires the Host Methyltransferase SETD3.                                                                        

 *Diep J, *Ooi YS, *Wilkinson AW et al. 

(2019) Nature Microbiology

An RNA-Centric Dissection of Host Complexes Controlling Flavivirus Infection.                                                         

*Ooi YS, *Majzoub K, *Flynn RA et al. 

(2019) Nature Microbiology

Mechanism of Tetherin Inhibition of Alphavirus Release.      

Wan JJ, Ooi YS, and Kielian M. 

(2019) Journal of Virology

SETD3 is an actin histidine methyltransferase that prevents primary dystocia.  

*Wilkinson AW, *Diep J, *Dai S, Liu S, Ooi YS et al. 

(2019) Nature

STAG2 deficiency induces IFN responses via cGAS-STING pathway and restricts virus infection. 

Ding S, Diep J, Feng N, Ren L, Li B, Ooi YS et al. 

(2018) Nature Communications

A small molecule oligosaccharyltransferase inhibitor with pan-flaviviral activity.  

Puschnik AS, Marceau CD, Ooi YS et al. 

(2017) Cell Reports 

Drebrin restricts rotavirus entry by inhibiting dynamin-mediated endocytosis. 

*Li B, *Ding S, Feng N, Mooney N, Ooi YS et al. 

(2017) PNAS 

Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens.  

*Marceau CD, *Puschnik AS, Majzoub K, Ooi YS et al. 

(2016) Nature

BST2/Tetherin inhibits alphavirus exit. 

Ooi YS, Dubé M, and Kielian M 

(2015)Viruses

Genome-wide RNAi screen identifies novel host proteins required for alphavirus entry.   

*Ooi YS, *Stiles K, *Liu CY et al 

(2013) PLoS Pathogens 

Reviews/Book Chapters/Commentaries:

A CRISPR toolbox to study virus-host interactions.   

Puschnik AS, Majzoub K, Ooi YS, and Carette JE 

(2017) Nature Reviews Microbiology 

Know your enemy and know yourself – the case of SARS-CoV-2 host factors                                          

*Lee WS, *Yousefi M , Yan BG , Yong CL, and Ooi YS                   

(2021) Current Opinion in Virology

A review of virus host factor discovery using CRISPR screening                                      

See WR, Yousefi M, Ooi YS

(2024) mBio 

Identification of Host Factors of Paramyxoviruses by siRNA Genome-Wide Screens

Yan B, Sigmundsson K, Ooi YS & Anderson DE 

(2024) Methods Mol Biol 

How a tick-borne virus enters human cells                                    
Ooi YS
(2025) Nature