Research
Under Construction..... Stay Tuned....
1. Surface Chemistry/Microfluidics/Microarrays/Nanoarrays.
Interfacing surface chemistry, advanced microscopy techniques and microfluidics with cell biology to study a range of cell behaviors and to develop new biotechnology assay platforms.
This research program aims to bridge material science and cell biology with synthetic organic chemistry to develop new surface chemistry and biophysical tools to study the internal and external cues that are critical for cell polarization and cell migration. We also develop new types of biomolecular microarrays and nanoarrays compatible with MALDI mass spectrometry for a range of small molecule and proteomic studies.
2. Organic Chemistry/Bio-Organic.
A Solution Based Switchable Chemoselective Redox Responsive (CRRL) Ligation and Release Strategy for Bioconjugation (a reversible bio-orthogonal ‘click’ chemistry).
This research program aims to use synthetic organic chemistry to develop a general dynamic ‘click’ conjugation and release strategy for new applications in chemical biology and material science.
3. Chemical Biology/Tissue Engineering.
Developing Liposome Fusion strategies for cell surface tailoring in order to spatially and temporally control cell-cell interactions for stem cell differentiation and as a chemoselective Tissue engineering based therapy.
This research program aims to integrate synthetic organic chemistry with cell biology to tailor cell surfaces with bio-orthogonal functional groups for subsequent control of cell assembly and disassembly for stem cell differentiation and tissue engineering applications.
4. Biodegradable Polymers/Hydrogels.
Developing novel polyketoesters that can be molded into films and particles as biodegradable, non-cytotoxic materials for tissue engineering scaffolds and as nanoparticle delivery reagents. Programmable hydrogels with control of 3D ligand presentation for studies of cell behavior and regenerative medicine applications.
This research program aims to develop new polyketoester polymers and chemoselective hydrogels for a range of biomaterial and tissue engineering applications.