Publications
1. Speaks S, McFadden MI, Zani A, Solstad A, Leumi S, Roettger JE, Kenney AD, Bone H, Zhang L, Denz PJ, Eddy AC, Amer AO, Robinson R, Cai C, Ma J, Hemann EA, Forero A*, and Yount JS*. Gasdermin D promotes influenza virus-induced mortality through neutrophil amplification of inflammation. Nature Communications. 2024. [abstract]
*Corresponding authors
2. Yount JS. 10 Promotion and Tenure Tips for Microbiologists and Immunologists. mBio. 2024. [abstract]
3. Jones DM, Tuazon JA, Read KA, Leonard MR, Pokhrel S, Sreekumar BK, Warren RT, Yount JS, Collins PL, and Oestreich KJ. Cytotoxic Programming of CD4+ T Cells is Regulated by Opposing Actions of the Related Transcription Factors Eos and Aiolos. Journal of Immunology. 2024. [abstract]
4. Xu J, Zhang Y, Qu P, Shamseldin M, Sung JY, Misny J, Thongpan I, KC M, Hall JM, Evans JP, Eltobgy M, Lu M, Ye C, Chamblee M, Liang X, Martinez-Sobrido L, Amer AO, Yount JS, Boyaka PN, Peeples ME, Liu SL, Dubey P, and Li J. A next generation instranasal trivalent MMS vaccine induces durable and broad protection against SARS-CoV-2 variants of concern. Proceedings of the National Academy of Sciences. 2023. [abstract]
5. Espada DE, Sara L, Cahill MP, Yang H, Phillips S, Martinez N, Kenney AD, Yount JS, Xiong Y, Lin MM, and Wu L. SAMHD1 impairs type I interferon induction through the MAVS, IKKE, and IRF7 signaling axis during viral infection. Journal of Biological Chemistry. 2023. [abstract]
6. Yang H, Espada CE, phillips S, Martinez N, Kenney AD, Yount JS, Xiong Y, and Wu L. The host anti-viral protein SAMHD1 suppresses NF-kB activation by interacting with the IKK complex during inflammatory responses and viral infection. Journal of Biological Chemistry. 2023. [abstract]
7. Shamseldin MM, Zani A, Kenney A, Evans J, Zeng C, Read KA, Caution K, Hall JM, Brown JM, Bunsch G, Corps KN, Chaiwatpongsakorn S, Mahesh KC, Lu M, Deora R, Peeples ME, Li J, Oestreich KJ, Liu SL, Yount JS, and Dubey P. Prime-pull immunization of mice with a BcfA-adjuvanted vaccine elicits mucosal immunity and prevents SARS-CoV-2 infection and pathology. Journal of Immunology. 2023. [abstract]
8. Read KA, Jones DM, Pokhrel S, Hales EDS, Varkey A, Tuazon JA, Eisele CD, Abdouni A, Saadey A, Warren RT, Powell MC, Boss JM, Hemann EA, Yount JS, Ghoneim HE, Lio CWJ, Freud AG, Collins PL, and Oestreich KJ. Aiolos modulates the TFH and CD4-CTL differentiation programs via reciprocal regulation of the Zfp831/TCF-1/Bcl-6 axis and CD25. Nature Communications. 2023. [abstract]
9. Kenney AD, Zani A, Kawahara J, Eddy AC, Wang XL, KC M,Lu M, Hemann EA, Li J, Peeples ME, Hall-Stoodley L, Forero A, Cai C, Ma J, and Yount JS. Interferon-induced transmembrane protein IFITM3 limits lethality of SARS-CoV-2 in mice. EMBO Reports. 2023. [abstract]
10. Bednash JS, Joshns F, Farkas D, Elhance A, Adair J, Cress K, Yount JS, Kenney AD, Londino JD, and Mallampalli RK. Inhibiting the deubiquitinase UCHL1 reduces SARS-CoV-2 viral uptake by ACE2. American Journal of Respiratory Cell and Molecular Biology. 2023. [abstract]
11. Shi G, Chiramel AI, Majdoul S, Lai KK, Dempsey T, Kenney A, Zani A, Eddy A, Zhang L, Das S, Beare PA, Andresson T, Kar S, Best SM, Yount JS, and Compton AA. Rapalogs downmodulate intrinsic immunity and promote cell entry of SARS-CoV-2. Journal of Clinical Investigation. 2022. [abstract]
12. Wu Q, Lafuse W, Kumar N, Saljoughian N, Zani A, Patton A, Ganesan LP, Yount JS, and Rajaram MVS. Influenza A virus modulates ACE2 expression and SARS-CoV-2 infectivity in human cardiomyocytes. iScience. 2022. [abstract]
13. Lu M, Chamblee M, Zhang Y, Ye C, Dravid P, Park JG, KC M, Trivedi S, Murthy SS, Sharma H, Cassady C, Chaiwatpongsakorn S, Liang X, Yount JS, Boyaka PN, Peeples ME, Martinez-Sobrido L, Kapoor A, and Li J. SARS-CoV-2 prefusion S stabilized by six rather than two prolines is more potent for inducing antibodies that neutralize viral variants. Proceedings of the National Academy of Sciences. 2022. [abstract]
14. Li T, Kenney AD, Liu H, Park JG, Fiches GN, Liu H, Zhou D, Biswas A, Zhao W, Que J, Santoso N, Martinez-Sobrido L, Yount JS, and Jian Zhu. SARS-CoV-2 Nsp14 associates with IMPDH2 and activates NF-kB signaling. Frontiers in Immunology. 2022. [abstract]
15. Zhang Y, Lu M, KC M, Shamseldin MM, Ye C, Dravid P, Chamblee M, Park JG, Trivedi S, Chaiwatpongsakorn S, Kenney A, Liang X, Yount JS, Kapoor A, Martinez-Sobrido L, Dubey P, Boyaka PN, Peeples ME, and Li J. A highly efficacious SARS-CoV-2 vaccine based on a live attenuated mumps vaccine. Proceedings of the National Academy of Sciences. 2022. [abstract]
16. Eltobgy M, Zani A…+33 authors…Yount JS*, and Amer AO*. Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and thrombosis. Proceedings of the National Academy of Sciences. 2022. [abstract]
*Corresponding authors
17. Kenney AD, Aron SL, Gilbert C, Kumar N, Chen P, Eddy A, Zhang L, Zani A, Vargas-Maldonado N, Speaks S, Kawahara J, Denz PJ, Dorn L, Accornero F, Ma J, Zhu H, Rajaram MVS, Cai C, Langlois RA, and Yount JS. Influenza virus replication in cardiomyocytes drives heart dysfunction and fibrosis. Science Advances. 2022. [abstract]
18. Martens C, Dorn L, Kenney AD, Basal S, Yount JS, and Accornero F. BEX1 is a critical determinant of viral myocarditis. PLOS Pathogens. 2022. [abstract]
19. Kudryashova E, Zani A, Vilmen G, Sharma A, Lu W, Yount JS*, and Kudryashov DS*. SARS-CoV-2 inactivation by human defensin HNP1 and retrocyclin RC-10. Journal of Molecular Biology. 2022. [abstract]
*Corresponding authors
20. Karthigeyan KP, Zhang L, Loiselle DR, Haystead TAJ, Bhat M, Yount JS*, and Kwiek JJ*. A biorthogonal chemical reporter for fatty acid synthase dependent protein acylation. Journal of Biological Chemistry. 2021. [abstract]
*Corresponding authors
21. Zeng C, Waheed AA, Li T, Yu J, Zheng YM, Yount JS, Wen H, Freed EO, and Liu SL. SERINC proteins potentiate antiviral type I IFN induction and proinflammatory signaling pathways. Science Signaling. 2021. [abstract]
22. Lu M, Zhang Y, Dravid P, Li A, Zeng C, K C M, Trivedi S, Sharma H, Chaiwatpongsakorn S, Zani A, Kenney A, Cai C, Ye C, Liang X, Qiu J, Martinez-Sobrido L, Yount JS, Boyaka PN, Liu SL, Peeples ME, Kapoor A, and Li J. A methyltransferase-defective VSV-based SARS-CoV-2 vaccine candidate provides complete protection against SARS-CoV-2 infection in hamsters. Journal of Virology. 2021. [abstract]
23. Mears MJ, Wallace MJ, Yount JS, Fowler LA, Jones PS, Mohler PJ, and Wold LE. Pandemic Solutions: Creation of specimen collection kits for SARS-CoV-2. MethodsX. 2021. [abstract]
24. Antonson AM, Kenney AD, Chen HJ, Corps KN, Yount JS, and Gur TL. Moderately pathogenic maternal influenza A virus infection disrupts placental integrity but spares the fetal brain. Brain, Behavior, and Immunity. 2021. [abstract]
25. Das T, Yount JS, and Hang HC. Protein S-palmitoylation in immunity. Open Biology, 2021. [abstract]
26. Lu M, Trivedi S, Zhang Y, Dravid P, Li A, Harder O, Mahesh KC, Chaiwatpongsakorn S, Zani A, Kenney A, Cai C, Ye C, Liang W, Shimamura M, McLellan J, Boyaka PN, Qiu J, Martinez-Sobrido L, Yount JS, Peeples M, Kapoor A, Niewiesk S, and Li J. A safe and highly efficacious measles virus-based vaccine expressing SARS-CoV-2 stabilized prefusion spike. Proceedings of the National Academy of Sciences. 2021. [abstract]
27. Kenney AD, Li Z, Bian Z, Zhou X, Li H, Whitson BA, Tan T, Cai C, Ma J, and Yount JS. Recombinant MG53 protein protects mice from lethal influenza virus infection. American Journal of Respiratory and Critical Care Medicine. 2021. [abstract]
28. Larue RC, Xing E, Kenney AD, Zhang Y, Tuazon JA, Li J, Yount JS, Li PK, and Sharma A. Rationally designed ACE2-derived peptides inhibit SARS-CoV-2. Bioconjugate Chemistry. 2021. [abstract]
29. Shi G, Kenney AD, Kudryashova E, Zani A, Zhang L, Lai KK, Hall-Stoodley L, Robinson RT, Kudryashov D, Compton AA*, and Yount JS*. Opposing activities of IFITM proteins in SARS-CoV-2 infection. EMBO Journal. 2021. [abstract]
*Corresponding authors
**Included in the ASM COVID-19 Research Registry. “The registry includes top ranked, COVID-19 research articles curated by experts.”
30. Webb LG, Veloz J, Pintado-Silva J, Ahu T, Rangel MV, Mutetwa T, Zhang L, Bernal-Rubio D, Gigueroa D, Carrau ML, Fenutria R, Potla U, Reid SP, Yount JS, Stapleford KA, Aguirre S, and Fernandez Sesma A. Chikunguna virus antagonizes cGAS-STING mediated type-I interferon responses by degrading cGAS. PLOS Pathogens. 2020. [abstract]
31. Cong A, Evans JP, Pearason R, Qu P, Zhen Y-M, Robinson RT, Hall-Stoodley L, Yount J, Pannu S, Mallampalli RK, Saif L, Oltz E, Lozanski G, and Liu S-L. Neutralizing antibody against SARS-CoV-2 spike in COVID-19 patients, health care workers and convalescent plasma donors: a cohort study using a rapid and sensitive high-throughput neutralization assay. JCI Insight. 2020. [abstract]
32. Sermersheim M, Kenney AD, Lin PH, McMichael TM, Cai C, Gumpper K, Adesanya TA, Li H, Zhou X, Park KH, Yount JS*, and Jianjie Ma*. MG53 suppresses interferon-beta and inflammation via regulation of ryanodine receptor-mediated intracellular calcium signaling. Nature Communications. 2020. [abstract]
*Corresponding authors
33. Chemudupati M, Kenney AD, Smith AC, Fillinger RJ, Zhang L, Zani A, Liu SL, Anderson MZ, Sharma A, and Yount JS. Short chain fatty acid butyrate promotes virus infection by repressing interferon stimulated genes. Journal of Virology. 2020. [abstract]
34. Qin Z, Bonifati S, St Gelais C, Li TW, Kim SH, Antonucci JM, Mahboubi B, Yount JS, Xiong Y, Kim B, and Wu L. The dNTPase activity of SAMDH1 is important for its suppression of innate immune responses in differentiated monocytic cells. Journal of Biological Chemistry. 2020. [abstract]
35. Zani A, Zhang L, Kenney A, McMichael TM, Chemudupati M, Kwiek JJ, Liu SL, and Yount JS. Interferon-Induced Transmembrane Proteins Inhibit Cell Fusion Mediated by Trophoblast Syncytins. Journal of Biological Chemistry. 2019. [abstract]
36. Kenney AD, McMichael TM, Imas A, Chesarino NM, Zhang L, Dorn LE, Wu Q, Alfaour O, Amari F, Chen M, Zani A, Chemudupati M, Accornero F, Coppola V, Rajaram MVS*, and Yount JS*. IFITM3 protects the heart during influenza virus infection. Proceedings of the National Academy of Sciences. 2019. [abstract]
*Corresponding authors.
37. Sharma A, McLaughlin RN, Basom RS, Kikawa C, OhAinle M, Yount JS, Emerman M, and Overbaugh J. Macaque interferon-induced transmembrane proteins limit replication of SHIV strains in an envelope-dependent manner. PLOS Pathogens. 2019. [abstract]
38. Chemudupati M, Kenney AD, Bonifati S, Zani A, McMichael TM, Wu L, and Yount JS. From APOBEC to ZAP: Diverse Mechanisms Used by Cellular Restriction Factors to Inhibit Virus Infections. Biochimica et Biophysica Acta – Molecular Cell Research. 2019. [abstract]
39. McMichael TM, Zhang Y, Kenney AD, Zhang L, Zani A, Lu M, Chemudupati M, Li J, and Yount JS. IFITM3 restricts human metapneumovirus infection. Journal of Infectious Diseases. 2018. [abstract]
40. Zani A and Yount JS. Antiviral protection by IFITM3 in vivo. Current Clinical Microbiology Reports. 2018. Review. [abstract]
41. Chen S, Bonifati S, Qin Z, St. Gelais C, Kodigepalli KM, Barrett BS, Kim SH, Antonucci JM, Ladner KJ, Vuzovetsky O, Knecht KM, Xiong Y, Yount JS, Guttridge DC, Santiago ML, and Wu L. SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-kB and interferon pathways. Proceedings of the National Academy of Sciences. 2018. [abstract]
42. McMichael TM, Zhang L, Chemudupati M, Hach JC, Kenney AD, Hang HC, and Yount JS. Palmitoyltransferase ZDHHC20 Enhances IFITM3 S-Palmitoylation and Antiviral Activity. Journal of Biological Chemistry. 2017. [abstract]
43. Chesarino NM, Compton A, McMichael TM, Zhang L, Kenney A, Soewarna V, Doering R, Davis M, Schwartz O, and Yount JS. IFITM3 requires an amphipathic helix for restriction of virus infections. EMBO Reports. 2017. [abstract]
44. Seveau S, Turner J, Gavrilin M, Torrelles JB, Hall-Stoodley L, Yount JS, and Amer AO. Checks and balances between the inflammasome and the autophagosome. Journal of Molecular Biology. 2017. Review. [abstract]
45. Kenney A, Dowdle JA, McMichael TM, Bozacca L, St. Gelais C, Panfill A, Schlesinger LS, Anderson MZ, Greene P, Lopez CB, Rosenberg B, Wu L, and Yount JS. Human Genetic Determinants of Viral Diseases. Annual Review of Genetics. 2017. Invited Review. [abstract]
46. McMichael TM, Chemudupati M, and Yount JS. A balancing act between IFITM3 and IRF3. Cellular and Molecular Immunology. 2017. Invited Commentary. [abstract]
47. Tsou LK, Yount JS, and Hang HC. Epigallocatechin-3-gallate inhibits bacterial virulence and invasion of host cells. Bioorganic and Medicinal Chemistry. 2017. [abstract]
48. St. Gelais C, Kim SH, Ding L, Yount JS, Ivanov D, Spearman P, and Wu L. A putative cyclin-binding motif in human SAMHD1 contributes to protein phosphorylation, localization and stability. Journal of Biological Chemistry. 2016. [abstract]
49. Compton A, Roy N, Porrot F, Billet A, Casartelli N, Yount JS, Liang C, and Schwartz O. Natural mutations in IFITM3 modulate post-translational regulation and toggle antiviral specificity. EMBO Reports. 2016. [abstract]
50. Antonucci J, St. Gelais C, de Silva S, Yount JS, Tang C, Ji X, Xiong Y, Kim B, and Wu L. RNase activity of SAMHD1 is not essential for HIV-1 restriction in cells. Nature Medicine. 2016. [abstract]
51. Percher A, Ramakrishnan S, Yuan X, Thinon E, Yount JS*, and Hang HC*. Mass-tag labeling reveals site-specific and quantitative levels of protein S-fatty acylation. Proceedings of the National Academy of Sciences. 2016. [abstract]
*Corresponding authors.
**Highlighted in ACS Chemical Biology, May 2016, Spotlight section.
52. Tsou LK, Lara-Tejero M, RoseFigura J, Zhang Z, Wang YC, Yount JS, Lefefre M, Dossa P, Kata J, Guan F, Lam W, Cheng YC, Galan J, and Hang HC. Anti-bacterial flavonoids from medicinal plants covalently inactivate type III protein secretion substrates. Journal of the American Chemical Society. 2016. [abstract]
53. Wang F, St. Gelais C, de Silva S, Zhang H, Geng Y, Shepard C, Kim B, Yount JS, Wu L. Phosphorylation of mouse SAMHD1 regulates its restriction of human immunodeficiency virus type 1 infection, but not murine leukemia virus infection. Virology. 2016. [abstract]
54. Chesarino NC, McMichael TM, and Yount JS. E3 ubiquitin ligase NEDD4 promotes influenza virus infection by decreasing levels of the antiviral protein IFITM3. PLOS Pathogens. 2015. [abstract]
55. Melvin, WJ, McMichael TM, Chesarino NC Hach JC, and Yount JS. IFITMs from mycobacteria confer resistance to influenza virus when expressed in human cells. Viruses. 2015. [abstract]
56. Chesarino NC, McMichael TM, and Yount JS. Regulation of the trafficking and antiviral activity of IFITM3 by post-translational modifications. Future Microbiology. 2014. Invited Review. [abstract]
57. Chesarino NM, Hach JC, Chen JL, Zaro BW, Rajaram M, Turner J, Schlesinger LS, Pratt M, Hang HC, and Yount JS. Chemoproteomics reveals Toll-like receptor fatty acylation. BMC Biology. 2014. [abstract]
58. Chesarino NC, McMichael TM, Hach JC, and Yount JS. Phosphorylation of the antiviral protein IFITM3 dually regulates its endocytosis and ubiquitination. Journal of Biological Chemistry. 2014. [abstract]
*Related artwork chosen for the journal cover.
59. St. Gelais C, Hach JC, DeSilva S, Yount JS, and Wu L. Identification of cell cycle proteins interacting with human and mouse anti-retroviral protein SAMHD1. Journal of Virology. 2014. [abstract]
60. Hach JC, McMichael T, Chesarino N, and Yount JS. Palmitoylation on conserved and non-conserved cysteines of murine IFITM1 regulates its stability and anti-influenza A virus activity. Journal of Virology. 2013. [abstract]
**Chosen by the editors for inclusion in “Spotlight,” a feature in the Journal of Virology that highlights research articles of significant interest.
61. Yount JS, Zhang MM, and Hang HC. Emerging roles for protein S-palmitoylation in immunity from chemical proteomics. Current Opinion in Chemical Biology. 2013. Review. [abstract]
62. Yount JS, Karssmeijer RA, and Hang HC. S-palmitoylation and ubiquitination differentially regulate interferon-induced transmembrane protein 3 (IFITM3)-mediated resistance to influenza virus. Journal of Biological Chemistry. 2012. [abstract]
63. Moltedo B, Li W, Yount JS, and Moran TM. Unique type I interferon responses determine the functional fate of migratory lung dendritic cells during influenza virus infection. PLOS Pathogens. 2011. [abstract]
64. Cotter C, Kim W-C, Nguyen M, Yount JS, López CB, Blaho J, and Moran TM. The virion host shut-off (vhs) protein of HSV-1 blocks the replication-independent activation of NF-κB in dendritic cells in the absence of type I interferon signaling. Journal of Virology. 2011. [abstract]
65. Yount JS, Zhang M, and Hang HC. Visualization and identification of fatty acylated proteins using chemical reporters. Current Protocols in Chemical Biology. 2011. [abstract]
66. Yount JS, Charron G, and Hang HC. Bioorthogonal proteomics of 15-hexadecynyloxyacetic acid chemical reporter reveals preferential targeting of fatty acid modified proteins and biosynthetic enzymes. Bioorganic & Medicinal Chemistry. 2011. [abstract]
67. Charron G, Tsou LK, Maguire W, Yount JS, and Hang HC. Alkynyl-farnesol reporters for detection of protein S-prenylation in cells. Molecular BioSystems. 2011. [abstract]
68. Yount JS, Moltedo B, Yang YY, Charron G, Moran TM, Lopez CB, and Hang HC. Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3. Nature Chemical Biology. 2010. [abstract]
*Reviewed by Faculty of 1000 Biology as “Must Read.”
69. Yount JS, Tsou LK, Dossa PD, Kullas AL, van der Velden AW, and Hang HC. Visible fluorescence detection of type III protein secretion from bacterial pathogens. Journal of the American Chemical Society. 2010. [abstract]
70. Cotter C, Nguyen ML, Yount JS, Lopez CB, Blaho JA, and Moran TM. The virion host shut-off (vhs) protein blocks a TLR-independent pathway of Herpes Simplex Virus type 1 recognition in dendritic cells. PLOS One. 2010. [abstract]
71. Charron G, Zhang MM, Yount JS, Wilson J, Raghavan AS, Shamir E, and Hang HC. Robust fluorescent detection of protein fatty-acylation with chemical reporters. Journal of the American Chemical Society. 2009. [abstract]
72. Friedman CS, O’Donnel MA, Legarda-Addison D, Cárdenas WB, Yount JS, Basler CF, Komuro A, Horvath CM, Sun S-C, Xavier R, Ting AT. The tumor suppressor CYLD is a negative regulator of RIG-I-mediated anti-viral response. EMBO Reports. 2008. [abstract]
73. Yount JS, Gitlin L, Moran TM, and Lopez CB. MDA5 participates in the detection of paramyxovirus infection and is essential for the early activation of dendritic cells in response to Sendai Virus defective interfering particles. Journal of Immunology. 2008. [abstract]
74. Yount JS, Moran TM, and Lopez CB. Cytokine-Independent Upregulation of MDA5 in Viral Infection. Journal of Virology. 2007. [abstract]
75. Yount JS, Kraus TA, Horvath CM, Moran TM, and Lopez CB. A Novel Role for Viral Defective Interfering Particles in Enhancing Dendritic Cell Maturation. Journal of Immunology. 2006. [abstract]
76. Lopez CB, Yount JS, Hermesh T, and Moran TM. Sendai Virus Infection Induces Efficient Adaptive Immunity Independently of Type I Interferons. Journal of Virology. 2006. [abstract]
77. Lopez CB, Yount JS, and Moran TM. Toll-Like Receptor-Independent Triggering of Dendritic Cell Maturation by Viruses. Journal of Virology. 2006. Review. [abstract]
