Publications

[67] King, E.A; Peairs, E.M,; Uthappa, D.M,; Villa, J.K.; Deitch, R.T.; Martin, A.K.; Young, D.D. "Photoregulation of PRMT-1 Using a Photolabile Unnatural Amino Acid" Molecules, 2021, 26, 5072-5080. https://doi.org/10.3390/molecules26165072

[65] Travis, C.R.; Mazur, L.E.; Peairs, E.M.; Gaunt, G.H.; Young, D.D. "Mechanistic Investigation and Further Optimization of the Aqueous Glaser-Hay Bioconjugation" Org. Biomol. Chem 2019 17, 3396-3402. DOI: 10.1039/c9ob00327d

[64] Young, D.D.; Schultz, P.G. "Playing with the Molecules of Life" ACS Chem. Biol. 2018 13, 854-870. https://doi.org/10.1021/acschembio.7b00974

[63] Chatkewitz, L.E.; Halonski, J.F.; Padilla, M.S.; Young, D.D. "Investigation of Copper-Free Alkyne/Azide 1,3-Dipolar Cycloadditions Using Microwave Irradiation" Bioorg. Med. Chem Lett. 2018, 28, 81-84. DOI: 10.1016/j.bmcl.2017.12.007

[62] Nimmo, Z.M.; Halonski, J.F.; Chatkewitz, L.E.; Young, D.D. "Development of Optimized Conditions for Glaser-Hay Bioconjugations" Bioorg. Chem. 2018, 76, 326-331. https://doi.org/10.1016/j.bioorg.2017.11.020

[61] Villa, J.K.; Tran, H.A.; Vipani, M.; Gianturco S.; Bhasin, K.; Russell B.L.; Harbron, E.J.; Young, D.D. "Fluorescence Modulation of Green Fluorescent Protein Using Fluorinated Unnatural Amino Acids" Molecules 2017, 22, 1194-1200. https://doi.org/10.3390/molecules22071194

[60] Maza, J.C.; Howard, C.A.; Vipani, M.A.; Travis C.R.; Young, D.D. "Utilization of Alkyne Bioconjugations to Modulate Protein Function" Bioorg. Med. Chem. Lett. 2017, 27, 30-33. doi: 10.1016/j.bmcl.2016.11.041

[59] Lampkowski, J.S.; Uthappa, D.M.; Maza, J.C.; Young, D.D. "Application of the Solid-Supported Glaser-Hay Reaction to Natural Product Synthesis" J. Org. Chem. 2016, 81, 12520-12524. https://doi.org/10.1021/acs.joc.6b02407

[58] Padilla, M.S.; Farley, C.A.; Chatkewitz, L.E.; Young, D.D. "Synthesis and Incorporation of a Caged Tyrosine Amino Acid Posessing a Bioorthogonal Handle" Tet. Lett. 2016, 57, 4709-4712. DOI: 10.1016/j.tetlet.2016.09.033

[57] Maza, J.C.; Villa, J.K.; Landino, L.M.; Young, D.D. "Utilizing Unnatural Amino Acids to Illustrate Protein Structure-Function Relationships: An Experiment Designed for an Undergraduate Biochemistry Laboratory" J. Chem. Ed. 2016, 93,767-771. https://doi.org/10.1021/acs.jchemed.5b00627

[56] Maza, J.C.; Nimmo, Z.M.; Young, D.D.; "Expanding the Scope of Alkyne-Mediated Bioconjugations Utilizing Unnatural Amino Acids" Chem. Commun. 2016, 52, 88-91. doi: 10.1039/c5cc08287k

[55] Maza, J.C.; Jacobs, T.H.; Uthappa, D.M.; Young, D.D.; "Employing Unnatural Amino Acids in the Preparation of Bioconjugates" Synlett 2016, 27, 805-813. (invited manuscript) DOI:10.1055/s-0035-1560551

[54] Lampkowski, J.S.; Uthappa, D.M.; Young, D.D.; "Site-Specific Incorporation of a Fluorescent Terphenyl Unnatural Amino Acid" Bioorg. Med. Chem. Lett. 2015, 25, 5277-5280. DOI: 10.1016/j.bmcl.2015.09.050

[53] Maza, J.C.; McKenna, J.R.; Raliski, B.K.; Freedman, M.T.; Young, D.D.; "Synthesis and Incorporation of Unnatural Amino Acids to Probe and Optimize Protein Bioconjugates" Bioconjug. Chem. 2015, 26,1884-1889. DOI: 10.1021/acs.bioconjchem.5b00424

[52] Lampkowski; J.S.; Bass, W.; Nimmo, Z.M.; Young, D.D.; "Microwave-Assisted Esterifications: An Unknowns Experiment Designed for an Undergraduate Organic Chemistry Laboratory" W. J. Chem Ed. 2015, 3, 111-114. doi: 10.12691/wjce-3-5-1

[51] Lampkowski, J.S.; Villa, J.K.; Young, T.S.; Young, D.D.; "Development and Optimization of Glaser-Hay Bioconjugations" Angew. Chem. Int. Ed. 2015 54, 9343-9346. DOI: 10.1002/anie.201502676

[50] Lampkowski, J.S.; Maza, J.C.; Verma, S.; Young, D.D.; "Optimization of Solid-Supported Glaser-Hay Reactions in the Microwave" Molecules 2015, 20, 5276-5285. (invited paper) DOI: 10.3390/molecules20045276

[49] Padilla, M.S.; Young, D.D.; "Photosensitive GFP Mutants Containing an Azobenzene Unnatural Amino Acid." Biol. Med. Chem. Lett. 2015, 25, 470-473. DOI: 10.1016/j.bmcl.2014.12.035

[48] Lampkowski, J.S.; Durham, C.E.; Padilla, M.S.; Young, D.D.; "Preparation of Asymmetrical Polyynes by a Solid-Supported Glaser-Hay Reaction." Org. Biomol. Chem. 2015, 13, 424-442. https://doi.org/10.1039/C4OB02196G

[47] Raliski, B.K.; Howard, C.A.; Young, D.D.; "Site-Specific Protein Immobilization Using Unnatural Amino Acids." ACS Bioconj. Chem. 2014. 25, 1916-1920. https://doi.org/10.1021/bc500443h

[46] Muetteries, C.; Janiga, A.; Huynh, K.; Pisano, M.G.; Tripp, V.T.; Young, D.D.; Poutsma, J.C.; "Gas-Phase Acid-Base Properties of Homocysteine, Homoserine, and 5-Hydroxynorvaline from the Extended Kinetic Method." Int. J. Mass Spectrom., 2014, 369, 71-80. https://doi.org/10.1016/j.ijms.2014.06.010

[45] Tripp, V.T.; Lampkowski, J.S.; Tyler, R.; Young, D.D.; "Development of Solid-Supported Glaser-Hay Couplings." ACS Combi. Sci. 2014. 16, 164-167. https://doi.org/10.1021/co500018k

[44] Rust, H.; Subramanian, V.; West, G.; Young, D.D.; Schultz. P.G.; Thompson, P.; "Using Unnatural Amino Acid Mutagenesis to Probe the Regulation of PRMT1." ACS Chem. Biol. 2014. 9, 649-655. DOI: 10.1021/cb400859z

[43] Govan, J.M.; Young, D.D.; Lusic, H.; Liu, Q.; Lively, M.O.; Deiters, A.; "Optichemical Control of RNA Interference in Mammalian Cells." Nuc. Acids Res. 2013. 41, 10518-1052. doi: 10.1093/nar/gkt806

[42] Tripp, V.T.; Maza, J.C.; Young, D.D.; "Development of Rapid Microwave Mediated and Low Temperature Bacterial Transformations." J. Chem. Biol. 2013. 6, 135-140. doi: 10.1007/s12154-013-0095-4

[39] Georgianna, W.E.; Young, D.D. “Development and Utilization of Non-Coding RNA-Small Molecule Interactions.” Org. Biomol. Chem. 2011, 9, 7969-7978. (Invited Review) DOI: 10.1039/c1ob06324c