Research Professor
Hei Yeun Koo, PhD
구 혜 연 박사
Research Areas
Tonotopic organization
Transcriptomic diversity of inner ear
Hei Yeun Koo, PhD
구 혜 연 박사
Tonotopic organization
Transcriptomic diversity of inner ear
Jae Won Roh†, Kyung Seok Oh†, Jiahn Lee, Yujin Choi, Soomin Kim, Ji Won Hong, Hei Yeun Koo, Haiyue Lin, Yelim Kim, Hogun Lew, Seung Hyun Jang, Hae-Sol Shin, Jiyeon Ohk, Hosung Jung, Kyoung Yul Seo, Jinsei Jung, Jinwoong Bok*, Chul Hoon Kim*, Heon Yung Gee* (2025) TMEM145 is a key stererociliary component in the link structures of outer hair cells and mediates the secretion of stereocilin and tubby. Nat Commun In Press
Seoyeong Kim, Jae Jin Shin, Muwon Kang, Yeji Yang, Yi Sul Cho, Hyojung Paik, Jimin Kim, Yunho Yi, Suho Lee, Hei Yeun Koo, Jinwoong Bok, Yong Chul Bae, Jin Young Kim, Eunjoon Kim (2025). Alternatively spliced mini-exon B in PTPdelta regulates excitatory synapses through cell-type-specific trans-synaptic PTPdelta-IL1RAP interaction. Nat Commun 16(1): 4415.
Hei Yeun Koo^, Jae Hwan Oh^, María Beatriz Durán Alonso, Iris López Hernández, Margarita González-Vallinas, María Teresa Alonso, Juan J. Tena, Alejandro Gil-Gálvez, Fernando Giraldez, Jinwoong Bok, Thomas Schimmang (2024) Analysis of Meis2 knockout mice reveals Sonic hedgehog-mediated patterning of the cochlear duct. Dev Dyn. 254:365–372.
Hei Yeun Koo, Min-A Kim, Hyehyun Min, Jae Yeon Hwang, Meenakshi Prajapati-DiNubila, Kwan Soo Kim, Martin M. Matzuk, Juw Won Park, Angelika Doetzlhofer, Un-Kyung Kim, Jinwoong Bok (2023) Follistatin regulates the specification of the apical cochlea responsible for low-frequency hearing in mammals. Proc Natl Acad Sci U S A 120(1):e2213099120
Kwan Soo Kim, Hei Yeun Koo, Jinwoong Bok (2023) Alternative splicing in shaping the molecular landscape of the cochlea. Front Cell Dev Biol 11: 1143428
Heiyeun Koo^, Jae Yeon Hwang^, Sungbo Jung, Hyeyoung Park, Jinwoong Bok*, Juw Won Park* (2021) Position Specific Alternative Splicing and Gene Expression Profiles Along the Tonotopic Axis of Chick Cochlea. Front Mol Biosci 8:726976
Kyeong-Hye Moon, Ji-Hyun Ma, Hyehyun Min, Heiyeun Koo, HongKyung Kim, Hyuk Wan Ko*, Jinwoong Bok* (2020) Dysregulation of sonic hedgehog signaling causes hearing loss in ciliopathy mouse models. eLife 9:e5655.
Harinarayana Ankamreddy^, Heiyeun Koo^, Young Jae Lee, Jinwoong Bok (2020) CXCL12 is required for stirrup-shaped stapes formation during mammalian middle ear development. Dev Dyn 249(9):1117-1126.