Yonsei Hearing Research

Hyehyun Min, PhD (민 혜 현 박사) - Research Professor (기초연구조교수)

Present: Dallas, USA

Han Seul Choi, Hyeyoung Park, Hyehyun Min, Kwan Soo Kim, Soo Min Kim, Jinan Li, Chang Liu, Hyuk Wan Ko, Min Goo Lee, Lei Song, Bo Zhao, Jinwoong Bok (2025) SHANK2 establishes auditory hair bundle architecture essential for mammalian hearing. Proc Natl Acad Sci U S A. In Press
Sun Young Joo^, Hyehyun Min^, Jung Ah Kim, Se Jin Kim, Seung Hyun Jang, Ho Lee, Kyu Min Kim, Je Kyung Seong, Jae Young Choi, Jinsei Jung*, Jinwoong Bok*, Heon Yung Gee* (2025) Bi-allelic variants of SEMA3F are associated with non-syndromic hearing loss. Mol Cells I48(3):100190
Jinsei Jung^, Sun Young Joo^, Hyehyun Min^, Jae Won Roh^, Kyung Ah Kim, Ji-Hyun Ma, John Hoon Rim, Jung Ah Kim, Se Jin Kim, Seung Hyun Jang, Young Ik Koh, Hye-Youn Kim, Ho Lee, Byoung Choul Kim, Heon Yung Gee*, Jinwoong Bok*, Jae Young Choi*, Je Kyung Seong* (2024) MYH1 deficiency disrupts the outer hair cell electromotility, resulting in hearing loss. Exp Mol Med. 56(11): 2423-2435.
Hei Yeun Koo, Min-A Kim, Hyehyun Min, Jae Yeon Hwang, Meenakshi Prajapati-DiNubila, Kwan Soo Kim, Martin M. Matzuk, Juw Won Park, Angelika Doetzlhofer, Un-Kyung Kim, Jinwoong Bok (2023) Follistatin regulates the specification of the apical cochlea responsible for low-frequency hearing in mammals. Proc Natl Acad Sci U S A. 120(1):e2213099120.
Song Yi Youn^, Hyehyun Min^, Se Rok Jeong, Jiahn Lee, Seok Jun Moon, Jinwoong Bok, Chul Hoon Kim (2022). Microtubule-associated protein 1 A and tubby act independently in regulating the localization of stereocilin to the tips of inner ear hair cell stereocilia. Mol Brain 15(1): 80
Ji-Hyun Ma^, Eunju Lee^, Sung-Hyun Yoon^, Hyehyun Min^, Jae Hwan Oh, Inhwa Hwang, Yejin Sung, Ju Hee Ryu, Jinwoong Bok*, Je-Wook Yu* (2022) Therapeutic effect of NLRP3 inhibition on hearing loss induced by systemic inflammation in a CAPS-associated mouse model. EBioMedicine 82:104148.
Kyeong-Hye Moon, Ji-Hyun Ma, Hyehyun Min, Heiyeun Koo, HongKyung Kim, Hyuk Wan Ko*, Jinwoong Bok* (2021) Dysregulation of sonic hedgehog signaling causes hearing loss in ciliopathy mouse models. eLife 9:e5655.
Woongsu Han^, Jeong-Oh Shin^, Ji-Hyun Ma^, Hyehyun Min, Jinsei Jung, Jinu Lee, Un-Kyung Kim, Jae Young Choi, Seok Jun Moon, Dae Won Moon*, Jinwoong Bok*, and Chul Hoon Kim* (2020) Distinct roles of stereociliary links in the nonlinear sound processing and noise resistance of cochlear outer hair cells. Proc Natl Acad Sci U S A 117(20):11109-11117.
Hyehyun Min, Hyoung-Pyo Kim, Jeong-Oh Shin (2019). Depletion of CTCF induces craniofacial malformations in mouse embryos. Am J Transl Res 11(9): 6102-6109.
Harinarayana Ankamreddy, Hyehyun Min, Jae Yoon Kim, Xiao Yang, Eui-Sic Cho, Un-Kyung Kim, Jinwoong Bok (2019) Region-specific endodermal signals direct neural crest cells to form the three middle ear ossicles. Development 146(2): dev167965.
Jeong-Oh Shin^, Jong-Joo Lee^, Mikyoung Kim, Youn Wook Chung, Hyehyun Min, Jae-Yoon Kim, Hyoung-Pyo Kim*, Jinwoong Bok* ( 2018). CTCF Regulates Otic Neurogenesis via Histone Modification in the Neurog1 Locus. Mol Cells 41(7): 695-702.
Byeonghyeon Lee, Jeong-In Baek, Hyehyun Min, Seung-Hyun Bae, Kyeonghye Moon, Min-A Kim, Ye-Ri Kim, Ben Fogelgren, Joshua H. Lipschutz, Kyu-Yup Lee, Jinwoong Bok*, Un-Kyung Kim* (2018). Exocyst Complex Member EXOC5 Is Required for Survival of Hair Cells and Spiral Ganglion Neurons and Maintenance of Hearing. Mol Neurobiol 55(8): 6518-6532.

Kyeong-Hye Moon, Ph.D. (문 경 혜 박사) - PhD Graduate (2021.02)

Present: Post-Doc (Harvard Medical School, MA, USA)

Hankyu Lee^, Kyeong-Hye Moon^, Jieun Song^, Suyeon Je, Jinwoong Bok*, Hyuk Wan Ko* (2022) Tissue-specific requirement of sodium channel and clathrin linker 1 (Sclt1) for ciliogenesis during limb development. Front Cell Dev Biol. 10: 1058895
Maíra Bianchi Rodrigues Alves, Laura Girardet, Céline Augière, Kyeong Hye Moon, Camille Lavoie-Ouellet, Agathe Bernet, Denis Soulet, Ezequiel Calvo, Maria E Teves, Charles Joly Beauparlant, Arnaud Droit, Alexandre Bastien, Claude Robert, Jinwoong Bok, Barry T Hinton, Clémence Belleannée (2022) Hedgehog signaling regulates Wolffian duct development through the primary cilium. Biol Repord. 108(2): 241-257
Kyeong-Hye Moon, Ji-Hyun Ma, Hyehyun Min, Heiyeun Koo, HongKyung Kim, Hyuk Wan Ko*, Jinwoong Bok* (2021) Dysregulation of sonic hedgehog signaling causes hearing loss in ciliopathy mouse models. eLife 9:e5655.
Byeonghyeon Lee, Jeong-In Baek, Hyehyun Min, Seung-Hyun Bae, Kyeonghye Moon, Min-A Kim, Ye-Ri Kim, Ben Fogelgren, Joshua H. Lipschutz, Kyu-Yup Lee, Jinwoong Bok*, Un-Kyung Kim* (2018). Exocyst Complex Member EXOC5 Is Required for Survival of Hair Cells and Spiral Ganglion Neurons and Maintenance of Hearing. Mol Neurobiol 55(8): 6518-6532.
Hirokazu Hashimoto, Wen Jiang, Takeshi Yoshimura, Kyeong-Hye Moon, Jinwoong Bok, Kazuhiro Ikenaka (2018). Strong sonic hedgehog signaling in the mouse ventral spinal cord is not required for oligodendrocyte precursor cell (OPC) generation but is necessary for correct timing of its generation. Neurochem Int 119: 178-183.

Dong Wook Lee (이 동 욱), Undergraduate Intern

Present: Medical school (Semmelweis University, Hungary)

Ji-Hyun Ma, PhD (마 지 현 박사) - PhD Graduate (2017.08)

Present: Research Professor (Kyungpook National University)

Jinsei Jung, Sun Young Joo, Hyehyun Min, Jae Won Roh, Kyung Ah Kim, Ji-Hyun Ma, John Hoon Rim, Jung Ah Kim, Se Jin Kim, Seung Hyun Jang, Young Ik Koh, Hye-Youn Kim, Ho Lee, Byoung Choul Kim, Heon Yung Gee*, Jinwoong Bok*, Jae Young Choi*, Je Kyung Seong* (2024) MYH1 deficiency disrupts the outer hair cell electromotility, resulting in hearing loss. Exp Mol Med. 56(11): 2423-2435.
Ji-Hyun Ma^, Eunju Lee^, Sung-Hyun Yoon^, Hyehyun Min^, Jae Hwan Oh, Inhwa Hwang, Yejin Sung, Ju Hee Ryu, Jinwoong Bok*, Je-Wook Yu* (2022) Therapeutic effect of NLRP3 inhibition on hearing loss induced by systemic inflammation in a CAPS-associated mouse model. EBioMedicine 82:104148.
Kyeong-Hye Moon, Ji-Hyun Ma, Hyehyun Min, Heiyeun Koo, HongKyung Kim, Hyuk Wan Ko*, Jinwoong Bok* (2021) Dysregulation of sonic hedgehog signaling causes hearing loss in ciliopathy mouse models. eLife 9:e5655.
Woongsu Han^, Jeong-Oh Shin^, Ji-Hyun Ma^, Hyehyun Min, Jinsei Jung, Jinu Lee, Un-Kyung Kim, Jae Young Choi, Seok Jun Moon, Dae Won Moon*, Jinwoong Bok*, and Chul Hoon Kim* (2020) Distinct roles of stereociliary links in the nonlinear sound processing and noise resistance of cochlear outer hair cells. Proc Natl Acad Sci U S A 117(20):11109-11117. ^equal contribution.
Ji-Hyun Ma, Hyoung-Pyo Kim, Jeong-Oh Shin (2019). CTCF deficiency causes expansion of the sensory domain in the mouse cochlea. Biochem Biophys Res Commun 512(4): 896-901.
Min-A Kim^, Sung Huhn Kim^, Nari Ryu, Ji-Hyun Ma, Ye-Ri Kim, Jinsei Jung, Chuan-Jen Hsu, Jae Young Choi, Kyu-Yup Lee*, Philine Wangemann*, Jinwoong Bok*, Un-Kyung Kim* (2019) Gene therapy for hereditary hearing loss by SLC26A4 mutations in mice reveals distinct functional roles of pendrin in normal hearing function. Theranostics 9(24):7184-7199.
Ji-Hyun Ma, Hyoung-Pyo Kim, Jinwoong Bok, Jeong-Oh Shin (2018). CTCF is required for maintenance of auditory hair cells and hearing function in the mouse cochlea. Biochem Biophys Res Commun 503(4): 2646-2652.
Ji-wook Kim^, Jae-Hyun Lee^, Ji-Hyun Ma^, Eunna Chung, Hongsuh Choi, Jinwoong Bok, Jinwoo Cheon (2016) Magnetic Force Nanoprobe for Direct Observation of Audio Frequency Tonotopy of Hair Cells. Nano Letters 16(6): 3885-3891. ^equal contribution.
Eun Jin Son^, Ji-Hyun Ma^, Harinarayana Ankamreddy, Jeong-Oh Shin, Jae Young Choi, Doris K. Wu, Jinwoong Bok (2015) Conserved role of Sonic Hedgehog in tonotopic organization of the avian basilar papilla and mammalian cochlea. Proc Natl Acad Sci U S A 112(12): 3746-51. ^equal contribution.

Jeong-Oh Shin, PhD (신 정 오 박사) - Research Professor

Present: Assistant Professor (Soonchunyang University College of Medicine)

Woongsu Han^, Jeong-Oh Shin^, Ji-Hyun Ma^, Hyehyun Min, Jinsei Jung, Jinu Lee, Un-Kyung Kim, Jae Young Choi, Seok Jun Moon, Dae Won Moon*, Jinwoong Bok*, and Chul Hoon Kim* (2020) Distinct roles of stereociliary links in the nonlinear sound processing and noise resistance of cochlear outer hair cells. Proc Natl Acad Sci U S A 117(20):11109-11117.
Jeong-Oh Shin^, Jieun Song^, Han Seul Choi, Jisu Lee, Kyeong Lee, Hyuk Wan Ko*, Jinwoong Bok* (2019) Activation of sonic hedgehog signaling by a Smoothened agonist restores congenital defects in mouse models of endocrine-cerebro-osteodysplasia syndrome. EBioMedicine 49:305-317.
Hyehyun Min, Hyoung-Pyo Kim, Jeong-Oh Shin (2019). Depletion of CTCF induces craniofacial malformations in mouse embryos. Am J Transl Res 11(9): 6102-6109.
Ji-Hyun Ma, Hyoung-Pyo Kim, Jeong-Oh Shin (2019) CTCF deficiency causes expansion of the sensory domain in the mouse cochlea. Biochem Biophys Res Commun 512(4): 896-901.
Jeong-Oh Shin^, Jong-Joo Lee^, Mikyoung Kim, Youn Wook Chung, Hyehyun Min, Jae-Yoon Kim, Hyoung-Pyo Kim*, Jinwoong Bok* (2018). CTCF Regulates Otic Neurogenesis via Histone Modification in the Neurog1 Locus. Mol Cells 41(7): 695-702.
Jeong-Oh Shin, Jong-Min Lee, Jinwoong Bok, Han-Sung Jung (2018). Inhibition of the Zeb family prevents murine palatogenesis through regulation of apoptosis and the cell cycle. Biochem Biophys Res Commun 506(1): 223-230.
Ji-Hyun Ma, Hyoung-Pyo Kim, Jinwoong Bok, Jeong-Oh Shin (2018). CTCF is required for maintenance of auditory hair cells and hearing function in the mouse cochlea. Biochem Biophys Res Commun 503(4): 2646-2652.
Do Yeon Kim, Yu Mi Woo, Sunyoung Lee, Sumin Oh, Yubin Shin, Jeong-Oh Shin, Eun Young Park, Je Yeong Ko, Eun Ji Lee, Jinwoong Bok, Kyung Hyun Yoo, and Jong Hoon Park (2018) Impact of miR-192 and miR-194 on cyst enlargement through EMT in autosomal dominant polycystic kidney disease. FASEB J fj201800563RR.
Seokwon Lee^, Jeong-Oh Shin^, Borum Sagong, Un-Kyung Kim*, Jinwoong Bok* (2017) Spatiotemporal expression patterns of clusterin in the mouse inner ear. Cell Tissue Res 370(1): 89-97.
Jeong-Oh Shin^, Harinarayana Ankamreddy^, Naga Mahesh Jakka, Seokwon Lee, Un-Kyung Kim, Jinwoong Bok (2017) Temporal and spatial expression patterns of Hedgehog receptors in the developing inner and middle ear. Int J Dev Biol 61(8-9): 557-563.
Yu Mi Woo, Do Yeon Kim, Nam Jin Koo, Yong-Min Kim, Sunyoung Lee, Je Yeong Ko, Yubin Shin, Bo Hye Kim, Hyowon Mun, Seonju Choi, Eun Ji Lee, Jeong-Oh Shin, Eun Young Park, Jinwoong Bok, Jong Hoon Park (2017) Profiling of miRNAs and target genes related to cystogenesis in ADPKD mouse models. Sci Rep 7(1): 14151.
Eun Jin Son^, Ji-Hyun Ma^, Harinarayana Ankamreddy, Jeong-Oh Shin, Jae Young Choi, Doris K. Wu, Jinwoong Bok (2015) Conserved role of Sonic Hedgehog in tonotopic organization of the avian basilar papilla and mammalian cochlea. Proc Natl Acad Sci U S A 112(12): 3746-51.
Se-Kyung Oh^, Jeong-Oh Shin^, Jeong-In Baek^, Jinwook Lee, Jae Woong Bae, Harinarayana Ankamerddy, Myoung-Jin Kim, Tae-Lin Huh, Zae-Young Ryoo, Un-Kyung Kim, Jinwoong Bok*, Kyu-Yup Lee* (2015) Pannexin 3 is required for normal progression of skeletal development in vertebrates. FASEB J 29:4473-84.
Heejung Moon, Jieun Song, Jeong-Oh Shin, Hankyu Lee, Hong-Kyung Kim, Jonathan T. Eggenschwiller, Jinwoong Bok*, Hyuk Wan Ko* (2014) Intestinal cell kinase, a protein associated with endocrine-cerebro-osteodysplasia syndrome, is a key regulator of cilia length and Hedgehog signaling. Proc Natl Acad Sci U S A 111(23): 8541-46.

Harinarayana Ankamreddy, PhD - PhD Graduate (2019.02)

Present: Assistant Professor (SRM Institute of Science Technology, India)

Harinarayana Ankamreddy, Jinwoong Bok, Andrew K. Groves (2020). Uncovering the Secreted Signals and Transcription Factors Regulating the Development of Mammalian Middle Ear Ossicles. Dev Dyn 249(12) 1410-1424.

Harinarayana Ankamreddy^, Heiyeun Koo^, Young Jae Lee, Jinwoong Bok (2020) CXCL12 is required for stirrup-shaped stapes formation during mammalian middle ear development. Dev Dyn 249(9):1117-1126.
Harinarayana Ankamreddy, Hyehyun Min, Jae Yoon Kim, Xiao Yang, Eui-Sic Cho, Un-Kyung Kim, Jinwoong Bok (2019) Region-specific endodermal signals direct neural crest cells to form the three middle ear ossicles. Development 146(2): dev167965.
Jeong-Oh Shin^, Harinarayana Ankamreddy^, Naga Mahesh Jakka, Seokwon Lee, Un-Kyung Kim, Jinwoong Bok (2017) Temporal and spatial expression patterns of Hedgehog receptors in the developing inner and middle ear. Int J Dev Biol 61(8-9): 557-563. ^equal contribution
Eun Jin Son^, Ji-Hyun Ma^, Harinarayana Ankamreddy, Jeong-Oh Shin, Jae Young Choi, Doris K. Wu, Jinwoong Bok (2015) Conserved role of Sonic Hedgehog in tonotopic organization of the avian basilar papilla and mammalian cochlea. Proc Natl Acad Sci U S A 112(12): 3746-51.
Se-Kyung Oh^, Jeong-Oh Shin^, Jeong-In Baek^, Jinwook Lee, Jae Woong Bae, Harinarayana Ankamerddy, Myoung-Jin Kim, Tae-Lin Huh, Zae-Young Ryoo, Un-Kyung Kim, Jinwoong Bok*, Kyu-Yup Lee* (2015) Pannexin 3 is required for normal progression of skeletal development in vertebrates. FASEB J 29:4473-84.
HongKyung Kim, Harinarayana Ankamreddy, Dong Jin Lee, Kyoung-Ah Kong, Hyuk Wan Ko, Myoung Hee Kim, Jinwoong Bok (2014) Pax3 function is required specifically for inner ear structures with melanogenic fates. Biochem Biophys Res Commun 445(3):608-14.

Jae Yoon Kim, MS (김 재 윤) - MS Graduate (2018.08)

Harinarayana Ankamreddy, Hyehyun Min, Jae Yoon Kim, Xiao Yang, Eui-Sic Cho, Un-Kyung Kim, Jinwoong Bok (2019) Region-specific endodermal signals direct neural crest cells to form the three middle ear ossicles. Development 146(2): dev167965.

Jeong-Oh Shin^, Jong-Joo Lee^, Mikyoung Kim, Youn Wook Chung, Hyehyun Min, Jae-Yoon Kim, Hyoung-Pyo Kim*, Jinwoong Bok* (2018). CTCF Regulates Otic Neurogenesis via Histone Modification in the Neurog1 Locus. Mol Cells 41(7): 695-702.

HongKyung Kim, PhD (김 홍 경 박사) - Research Professor

Present: Research Professor (Korean Mouse Sensory Phenotyping Center)

Kyeong-Hye Moon, Ji-Hyun Ma, Hyehyun Min, Heiyeun Koo, HongKyung Kim, Hyuk Wan Ko*, Jinwoong Bok* (2021) Dysregulation of sonic hedgehog signaling causes hearing loss in ciliopathy mouse models. eLife 9:e5655.

HongKyung Kim, Harinarayana Ankamreddy, Dong Jin Lee, Kyoung-Ah Kong, Hyuk Wan Ko, Myoung Hee Kim, Jinwoong Bok (2014) Pax3 function is required specifically for inner ear structures with melanogenic fates. Biochem Biophys Res Commun 445(3):608-14.

Dong Jin Lee, MS (이 동 진) - MS Graduate (2013.02)

Present: 차장 Theragen Etex (테라젠 이텍스)

HongKyung Kim, Harinarayana Ankamreddy, Dong Jin Lee, Kyoung-Ah Kong, Hyuk Wan Ko, Myoung Hee Kim, Jinwoong Bok (2014) Pax3 function is required specifically for inner ear structures with melanogenic fates. Biochem Biophys Res Commun 445(3):608-14.

Mee Hyun Song, Soo-Young Choi, Ling Wu, Se-Kyoung Oh, Hee Keun Lee, Dong Jin Lee, Dae-Bo Shim, Jae Young Choi, Un-Kyung Kim, Jinwoong Bok (2011) Pou3f4 deficiency causes defects in otic fibrocytes and stria vascularis by different mechanisms. Biochem Biophys Res Commun 404(1): 528-533.
Heejei Yoon, Dong Jin Lee, Myoung Hee Kim, Jinwoong Bok (2011) Identification of genes concordantly expressed with Atoh1 during inner ear development. Anat Cell Biol 44(1): 69-78.

Naga Mahesh Jakka, PhD (나가 마헤시 자카) - Post-doctoral fellow

Jeong-Oh Shin^, Harinarayana Ankamreddy^, Naga Mahesh Jakka, Seokwon Lee, Un-Kyung Kim, Jinwoong Bok (2017) Temporal and spatial expression patterns of Hedgehog receptors in the developing inner and middle ear. Int J Dev Biol 61(8-9): 557-563.

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