Publications

Selected Publications

Hwang SS*, Lim J*, Yu Z, Kong P, Sefik E, Xu H, Harman CCD, Kim LK, Lee GR, Li H, Flavell RA “mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence” Science (2020) Mar 13;367(6483):1255-1260. (*co-first) (IF : 63.714)  – Faculty of 1000 Prime Recommended paper

Jang SW*, Hwang SS*, Kim HS , Kim MK, Lee WH, Hwang SU, Gwak J, Yew SK, Flavell RA, Lee GR. “Homeobox protein Hhex negatively regulates Treg cells by inhibiting Foxp3 expression and function” Proceedings of National Academy of Sciences of the United States of America (2019) Dec;116(51):25790-25799. (*co-first) (IF : 12.779)

Hwang SS*, Jang SW*, Lee KO, Kim HS, Lee GR. “RHS6 coordinately regulates the Th2 cytokine genes by recruiting GATA3, SATB1, and IRF4” Allergy (2017) May;72(5):772-782 (*co-first) (IF : 14.710)

Hwang SS, Jang SW, Kim MK, Kim LK, Kim BS, Kim HS, Kim K, Lee W, Flavell RA, Lee GR. “YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity” Nature Communications (2016) 7:10789 (IF : 17.694)

Hwang SS, Kim YU, Lee S, Jang SW, Kim MK, Koh BH, Lee W, Kim J, Souabni A, Busslinger M, Lee GR. "Transcription factor YY1 is essential for regulation of the Th2 cytokine locus and for Th2 cell differentiation" Proceedings of National Academy of Sciences of the United States of America (2012) 110(1):276-81 (IF : 12.779)

Koh BH*, Hwang SS*, Kim JY, Lee W, Kang MJ, Lee CG, Park JW, Flavell RA, Lee GR. "Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma" Proceedings of National Academy of Sciences of the United States of America (2010) 107(23):10614-9 (*co-first) (IF : 12.779)

Publications

[26] Choi JO*, Ham JH*, Hwang SS.  “RNA Metabolism in T Lymphocytes ” Immune Network (2022) Oct;22(5):e39 (Corresponding Author)

[25] Kim SH*, Jung IR*, Hwang SS.  “Emerging role of anti-proliferative protein BTG1 and BTG2” BMB Report (2022) Aug;55(8):380-388. (Corresponding Author)

[24] Hwang SS*, Lim J*, Yu Z, Kong P, Sefik E, Xu H, Harman CCD, Kim LK, Lee GR, Li H, Flavell RA “mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence” Science (2020) Mar 13;367(6483):1255-1260. (*co-first)

[23] Jang SW*, Hwang SS*, Kim HS , Kim MK, Lee WH, Hwang SU, Gwak J, Yew SK, Flavell RA, Lee GR. “Homeobox protein Hhex negatively regulates Treg cells by inhibiting Foxp3 expression and function” Proceedings of National Academy of Sciences of the United States of America (2019) Dec;116(51):25790-25799. (*co-first)

[22] Ryu HY, López-Giráldez F, Knight J, Hwang SS, Renner C, Kreft SG, Hochstrasser M. “Distinct adaptive mechanisms drive recovery from aneuploidy caused by loss of the Ulp2 SUMO protease.” Nature Communications (2018) 9(1):5417

[21] Kwon JE, Lee SY, Seo HB, Moon YM, Ryu JG, Jung KA, Jhun JY, Park JS, Hwang SS, Kim JM, Lee GR, Park SH, Cho ML “YinYang1 deficiency ameliorates joint inflammation in a murine model of rheumatoid arthritis by modulating Th17 cell activation.” Immunology Letters (2018) 197:63-69.

[20] Kim HS, Jang SW, Lee W, Kim K, Sohn H, Hwang SS, Lee GR “PTEN drives Th17 cell differentiation by preventing IL-2 production.” Journal of Experimental Medicine (2017) 214(11):3381-3398.

[19] Jang SW, Hwang SS, Kim HS, Lee KO, Lee W, Kim KW, Lee GR “Casein kinase 2 is a critical determinant of Th17 versus Treg cell differentiation” Experimental & Molecular Medicine (2017) 49(9):e375.

[18] Lee W, Kim HS, Hwang SS, Lee GR “Transcription factor Batf3 inhibits differentiation of regulatory T cells in the periphery” Experimental & Molecular Medicine (2017) 49(11):e393

[17] Kim BS, Tilstam PV, Springenberg-Jung K, Boecker AH, Schmitz C, Heinrichs D, Hwang SS, Stromps JP, Ganse B, Kopp R, Knobe M, Bernhagen J, Pallua N, Bucala R “Characterization of adipose tissue macrophages and adipose-derived stem cells in critical wounds.” PeerJ (2017) Jan 4;5:e2824.

[16] Kim BS, Tilstam PV, Hwang SS, Simons D, Schulte W, Leng L, Sauler M, Ganse B, Averdunk L, Kopp R, Stoppe C, Bernhagen J, Pallua N, Bucala R “D-dopachrome tautomerase in adipose tissue inflammation and wound repair.” Journal of Cellular and Molecular Medicine (2017) Jan; 21(1):35-45. 

[15] Hwang SS*, Jang SW*, Lee KO, Kim HS, Lee GR. “RHS6 coordinately regulates the Th2 cytokine genes by recruiting GATA3,

SATB1, and IRF4” Allergy (2017) May;72(5):772-782 (*co-first) 

[14] Hwang SS, Jang SW, Lee GR. “RHS6-mediated chromosomal looping and nuclear substructure binding is required for Th2 cytokine gene expression” Biochimica et Biophysica Acta - Gene Regulatory Mechanisms (2017) Mar;1860(3):383-391

[13] Hwang SS*, Kim LK*, Lee GR, Flavell RA., “Role of OCT-1 and partner proteins in T cell differentiation”, Biochimica et Biophysica Acta - Gene Regulatory Mechanisms (2016) Jun;1859(6):825-31 (*co-first)

[12] Hwang SS, Jang SW, Kim MK, Kim LK, Kim BS, Kim HS, Kim K, Lee W, Flavell RA, Lee GR. “YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity” Nature Communications (2016) 7:10789

[11] Ryu HY, Wilson NR, Mehta S, Hwang SS, Hochstrasser M. “Loss of the SUMO protease Ulp2 triggers a specific multichromosome aneuploidy.” Genes & Development. (2016) Aug 15;30(16):1881-94.

[10] Kim BS, Gaul C, Paul NE, Dewor M, Stromps JP, Hwang SS, Nourbakhsh M, Bernhagen J, Rennekampff HO, Pallua N. “The Effect of Lipoaspirates on Human Keratinocytes.” Aesthetic Surgery Journal. (2016) Sep;36(8):941-51.

[9] Park HJ, Kim DH, Choi JY, Kim WJ, Kim JY, Senejani AG, Hwang SS, Kim LK, Tobiasova Z, Lee GR, Craft J, Bothwell AL, Choi JM. "PPARγ negatively regulates T cell activation to prevent follicular helper T cells and germinal center formation" PLOS ONE (2014)

[8] Williams A, Lee GR, Spilianakis CG, Hwang SS, Eisenbarth SC, Flavell RA. "Hypersensitive site 6 of the Th2 locus control region is essential for Th2 cytokine expression" Proceedings of National Academy of Sciences of the United States of America (2013) 110(17):6955-60

[7] Hwang SS, Kim K, Lee W, Lee GR. "Aberrant expression of IFN-γ in Th2 cells from Th2 LCR-deficient mice" Biochemical and Biophysical Research Communications (2012) 424(3):512-8

[6] Hwang SS, Kim YU, Lee S, Jang SW, Kim MK, Koh BH, Lee W, Kim J, Souabni A, Busslinger M, Lee GR. "Transcription factor YY1 is essential for regulation of the Th2 cytokine locus and for Th2 cell differentiation" Proceedings of National Academy of Sciences of the United States of America (2012) 110(1):276-81

[5] Hwang SS, Kim K, Lee GR."Defective GATA-3 expression in Th2 LCR-deficient mice" Biochemical and Biophysical Research Communications (2011) 410(4):866-71

[4] Koh BH*, Hwang SS*, Kim JY, Lee W, Kang MJ, Lee CG, Park JW, Flavell RA, Lee GR. "Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma" Proceedings of National Academy of Sciences of the United States of America (2010) 107(23):10614-9 (*co-first)

[3] Hwang SS, Lee S, Lee W, Lee GR."GATA3 regulates Th2 cytokine and ifng loci through interaction with MTA2" Immunology (2010) 131(1): 50–58

[2] Hwang SS, Kim YU, Lee W, Lee GR. "Differential Expression of Nuclear Receptors in T Helper Cells" Journal of Microbiology and Biotechnology (2009) 19(2):208-14

[1] Kim K, Kim YU, Koh BH, Hwang SS, Kim SH, Lépine F, Cho YH, Lee GR. "HHQ and PQS, two Pseudomonas aeruginosa quorum-sensing molecules, down-regulate the innate immune responses through the nuclear factor-kB pathway" Immunology (2009) 129(4):578-88