Research
Research
"The immune system's pivotal role in shaping the intricacies of the neuronal system is gaining ever greater recognition. Historically, much of the research has focused on the detrimental effects of immune activation on the brain throughout our lifespan. Consider, for instance, the heightened risk of neurological and neurodevelopmental disorders associated with immune activation during pregnancy, or the acceleration of neurodegenerative disorders by an influx of immune cells into the brain.
"The immune system's pivotal role in shaping the intricacies of the neuronal system is gaining ever greater recognition. Historically, much of the research has focused on the detrimental effects of immune activation on the brain throughout our lifespan. Consider, for instance, the heightened risk of neurological and neurodevelopmental disorders associated with immune activation during pregnancy, or the acceleration of neurodegenerative disorders by an influx of immune cells into the brain.
But here's the intriguing question: Why does our brain still require the oversight and involvement of the immune system, even when immune activation appears to be a double-edged sword? Recent breakthroughs have hinted at the potential, previously unexplored, beneficial impact of immune activation within the brain.
But here's the intriguing question: Why does our brain still require the oversight and involvement of the immune system, even when immune activation appears to be a double-edged sword? Recent breakthroughs have hinted at the potential, previously unexplored, beneficial impact of immune activation within the brain.
The Yim lab is at the forefront of this exciting frontier, where we are passionately driven to unravel the mysteries surrounding cytokines, cytokine receptors, and the migration of immune cells in the context of a healthy brain. Join us on this exhilarating journey as we seek to illuminate the vital role of the immune system in maintaining the well-being of our most complex organ—the brain."
The Yim lab is at the forefront of this exciting frontier, where we are passionately driven to unravel the mysteries surrounding cytokines, cytokine receptors, and the migration of immune cells in the context of a healthy brain. Join us on this exhilarating journey as we seek to illuminate the vital role of the immune system in maintaining the well-being of our most complex organ—the brain."
Molecular and Genetic Dissection of the Cytokine-Regulatory Network in the Developing Brain
Molecular and Genetic Dissection of the Cytokine-Regulatory Network in the Developing Brain
This project introduces a novel concept suggesting that the immune system orchestrates neurodevelopment by utilizing a variety of cytokines and their corresponding receptors, which are expressed in the developing emrbyo’s brain.
This project introduces a novel concept suggesting that the immune system orchestrates neurodevelopment by utilizing a variety of cytokines and their corresponding receptors, which are expressed in the developing emrbyo’s brain.
Investigation of the Non-Conventional Role of Immune Cells in the Brain
Investigation of the Non-Conventional Role of Immune Cells in the Brain
The primary objective of this project is to elucidate the underlying mechanisms by examining how immune cells engage in communication with brain-resident cells, such as neurons, microglia, and astrocytes.
The primary objective of this project is to elucidate the underlying mechanisms by examining how immune cells engage in communication with brain-resident cells, such as neurons, microglia, and astrocytes.
Age-Related Inflammatory Changes and Their Impact on Cognitive Function
Age-Related Inflammatory Changes and Their Impact on Cognitive Function
This research aims to investigate whether and how CD8+ T cells influence the status of microglia, ultimately leading to aging-related phenotypes in the brain.
This research aims to investigate whether and how CD8+ T cells influence the status of microglia, ultimately leading to aging-related phenotypes in the brain.