▶ Publications
2025
1. Kim DH*, Choi G*, Song EB*, Lee H*, Kim J*, Jang YS, Park J, Chi S, Han J, Kim SM, Kim D, Bae SH, Lee HW, Park JY, Kang SG#, Cha SH#, Han YH#. Treatment of IL-18 binding protein biologics suppresses fibrotic progression in metabolic dysfunction-associated steatohepatitis. Cell Rep Med. 2025 Apr 15;6:102047. (IF: 11.7)
2. Kim NH*, Sim SJ*, Han HG*, Yoon JH*, Han YH. Immunosenescence and age-related immune cells: causes of age-related diseases. Arch Pharm Res. 2025 Feb;48(2):132-149. (IF: 6.9)
3. Kim NH, Kim MY, Yang YM, Jeong WI, Lee HW, Kim W, Kang SG, Han YH. Bacterial components-driven intrahepatic CXCR5hi B cells are important population for MASH progression through inducing inflammation. FASEB J. 2025 Jan 31;39(2):e70322. (IF: 4.4)
2024
1. Kim DH , Kim J, Park J, Kim TH, Han YH. Blockade of forkhead box protein O1 signaling alleviates primary sclerosing cholangitis-induced sarcopenia in mice model. Life Sci. 2024 Nov 1;356:123042. (IF: 5.2)
2. Lee Y, Lee R, Kim J, Han YH, Hunter C, Park J. Comparative analysis of changes in immune cell in the chicken spleen across different ages using flow cytometry. BMC Vet Res. 2024 Sep 28;20(1):429.
3. Kim NH*, Lee SJ*, Lee KJ, Song AR, Park HJ, Kang JS, Cha JY#, Han YH#. The Root Extract of Rosa multiflora Ameliorates Nonalcoholic Steatohepatitis Development via Blockade of De Novo Lipogenesis and Inflammation. Curr Issues Mol Biol. 2024 June 12;46(6):5881-5893. (IF: 3.1)
4. Kim HJ, Lee SH, Jeong C, Han YH, Lee MO. RORα-GABP-TFAM axis alleviates myosteatosis with fatty atrophy through reinforcement of mitochondrial capacity. J Cachexia Sarcopenia Muscle. 2024 Apr;15(2):615-630.
5. Kim MY*, Jeong B*, Lee GS, Jeon H, Yang YM, Yang H#, Han YH#. Panaxydol extracted from Panax ginseng inhibits NLRP3 inflammasome activation to ameliorate NASH-induced liver injury. Int Immunopharmacol. 2024 Feb 15;128:111565. doi: 10.1016/j.intimp.2024.111565. (IF: 5.6)
6. Ko JY, Kim MY, Jeon JY, Yi Jung J, Han YH#, Kim JH#. Syntheses of the ω-pyridinium-containing very-long-chain ceramides PyrCer(24:1(15Z)) and PyrCer(24:0) and their anticancer activity. Bioorg Med Chem Lett. 2024 Jan 15;98:129585. (IF: 2.7)
2023
1. Jang YS, Lee K, Park M, Park JJ, Choi GM, Kim C, Dehkohneh SB, Chi S, Han J, Song MY, Han YH#, Cha SH#, Kang SG#. Albumin-binding recombinant human IL-18BP ameliorates macrophage activation syndrome and atopic dermatitis via direct IL-18 inactivation. Cytokine. 2023 Dec;172:156413. (IF: 3.8)
2. Kim DH, Lee KJ, Park J, Chi S, Han J, Bang Y, Kim SM, Kang SG#, Cha SH#, Han YH#. Disruption of IL-18 signaling via engineered IL-18BP biologics alleviates experimental cholestatic liver disease. Biomed Pharmacother. 2023 Nov;167:115587. (IF: 7.5)
3. Lee KJ*, An S*, Kim MY, Kim SM, Jeong WI, Ko HJ, Yang YM, Noh M, Han YH. Hepatic TREM2+ macrophages express matrix metalloproteinases to control fibrotic scar formation. Immunol Cell Biol. 2023 Mar;101(3):216-230. (IF: 4)
2022
1. Kim MY*, Lee SJ*, Randolph GJ, Han YH. Lubiprostone significantly represses fatty liver diseases via induction of mucin and HDL release in mice. Life Sci. 2022 Dec 15;311(Pt A):121176. (IF: 6.78)
2. Han YH*, Choi H*, Kim HJ, Lee MO. Chemotactic cytokines secreted from Kupffer cells contribute to the sex-dependent susceptibility to non-alcoholic fatty liver diseases in mice. Life Sci. 2022 Oct 1;306:120846. (IF: 6.78)
3. Onufer EJ, Czepielewski RS, Han YH, Courtney CM, Sutton S, Sescleifer A, Randolph GJ, Warner BW. Lipid absorption and overall intestinal lymphatic transport are impaired following partial small bowel resection in mice. Sci Rep. 2022 Jul 7;12(1):11527.
4. Lee KJ*, Kim MY*, Han YH. Roles of heterogenous hepatic macrophages in the progression of liver diseases. BMB Rep. 2022 Apr;55(4):166-174. (IF: 5.041)
5. Hong DG, Song GY, Eom CB, Ahn JH, Kim SM, Shim A, Han YH, Roh YS, Han CY, Bae EJ, Ko HJ, Yang YM. Loss of ERdj5 exacerbates oxidative stress in mice with alcoholic liver disease via suppressing Nrf2. Free Radic Biol Med. 2022 May 1:184:42-52.
6. Kim JY, Yang IS, Kim HJ, Yoon JY, Han YH, Seong JK, Lee MO. RORα contributes to the maintenance of genome ploidy in the liver of mice with diet-induced nonalcoholic steatohepatitis. Am J Physiol Endocrinol Metab. 2022 Feb 1;322(2):E118-E131.
2021
1. Czepielewski RS, Erlich EC, Onufer EJ, Young S, Saunders BT, Han YH, Wohltmann M, Wang PL, Kim KW, Kumar S, Hsieh CS, Scallan JP, Yang Y, Zinselmeyer BH, Davis MJ, Randolph GJ. Ileitis-associated tertiary lymphoid organs arise at lymphatic valves and impede mesenteric lymph flow in response to tumor necrosis factor. Immunity. 2021 Dec 14;54(12):2795-2811.e9.
2. Kim HJ, Han YH, Kim JY, Lee MO. RORα Enhances Lysosomal Acidification and Autophagic Flux in the Hepatocytes. Hepatol Commun. 2021 Dec;5(12):2121-2138.
3. Han YH, Lee K, Saha A, Han J, Choi H, Noh M, Lee YH, Lee MO. Specialized Proresolving Mediators for Therapeutic Interventions Targeting Metabolic and Inflammatory Disorders. Biomol Ther (Seoul). 2021 Sep 1;29(5):455-464. (IF: 4.634)
4. Han YH*, Onufer EJ, Huang LH, Sprung RW, Davidson WS, Czepielewski RS, Wohltmann M, Sorci-Thomas MG, Warner BW, Randolph GJ*. Enterically derived high-density lipoprotein restrains liver injury through the portal vein. Science. 2021 July 23;373:eabe6729. (IF: 63.714)
5. Li J, Li E, Czepielewski RS, Chi J, Guo X, Han YH, Wang D, Wang L, Hu B, Dawes B, Jacobs C, Tenen D, Lin SJ, Lee B, Morris D, Tobias A, Randolph GJ, Cohen P, Tsai L, Rosen ED. Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells. Cell Metab. 2021 Jul 6;33(7):1449-1465.e6.
6. Onufer EJ*, Han YH*, Courtney CM, Steinberger AE, Tecos ME, Sutton S, Sescleifer A, Ou J, Sanguinetti Czepielewski R, Randolph GJ, Warner BW. Liver injury after small bowel resection is prevented in obesity-resistant 129S1/SvImJ mice. Am J Physiol Gastrointest Liver Physiol. 2021 May 1;320(5):G907-G918. (IF: 4.052)
7. Han YH, Kim HJ, Lee MO. RORalpha regulates hepatic lipolysis by inducing transcriptional expression of PNPLA3 in mice. Mol Cell Endocrinol. 2021 Feb 15;522:111122. (IF: 4.102)
2020
1. Han YH, Kim HJ, Choi H, Lee S, Lee MO. RORα autoregulates its transcription via MLL4-associated enhancer remodeling in the liver. Life Sci. 2020 Sep 1;256:118007. (IF: 3.647)
2. Onufer EJ, Han YH, Czepielewski R, Courtney CM, Sutton S, Randolph GJ*, Warner BW*. Effects of high fat diet on liver injury after small bowel resection. J Pediatr Surg. 2020 Jun;55(6):1099-1106.
2014-2019
1. Kim JY*, Han YH*, Nam MW, Kim HJ, Lee MO. RORα suppresses interleukin-6-mediated hepatic acute phase response. Sci Rep. 2019 Aug 13;9:11798. (IF: 3.998)
2. Han YH, Shin KO, Khadka D, Kim JY, Kim HJ, Cho WJ, Cha JY, Lee YM, Lee BJ, Lee MO. A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis. J Clin Invest. 2019 Mar 11;130:1684-1698. (IF: 19.447)
3. Han YH, Kim HJ, Na H, Nam MW, Kim JY, Kim JS, Koo SH, Lee MO. RORα Induces KLF4-Mediated M2 Polarization in the Liver Macrophages that Protect against Nonalcoholic Steatohepatitis. Cell Rep. 2017 Jul 5;20:124-135. (IF: 9.995)
4. Kim HJ, Han YH, Na H, Kim JY, Kim T, Kim HJ, Shin C, Lee JW, Lee MO. Liver-specific deletion of RORα aggravates diet-induced nonalcoholic steatohepatitis by inducing mitochondrial dysfunction. Sci Rep. 2017 Nov 22;7:16041.
5. Na TY, Kim GH, Oh HJ, Lee MH, Han YH, Kim KT, Kim JS, Kim DD, Lee MO. The trisaccharide raffinose modulates epidermal differentiation through activation of liver X receptor. Sci Rep. 2017 Mar 7;7:43823.
6. Han YH, Kim DK, Na TY, Ka NL, Choi HS, Lee MO. RORα switches transcriptional mode of ERRγ that results in transcriptional repression of CYP2E1 under ethanol-exposure. Nucleic Acids Res. 2016 Feb 18;44:1095-1104. (IF: 19.160)
7. Na TY, Han YH, Ka NL, Park HS, Kang YP, Kwon SW, Lee BH, Lee MO. 22-S-Hydroxycholesterol protects against ethanol-induced liver injury by blocking the auto/paracrine activation of MCP-1 mediated by LXRα. J Pathol. 2015 Apr;235: 710–720.
8. Han YH, Kim HJ, Kim EJ, Kim KS, Hong S, Park HG, Lee MO. RORα decreases oxidative stress through the induction of SOD2 and GPx1 expression and thereby protects against nonalcoholic steatohepatitis in mice. Antioxid Redox Signal. 2014 Nov 20;21: 2083-2094. (IF: 7.407)
9. Kim EJ, Choi YK, Han YH, Kim HJ, Lee IK, Lee MO. RORα suppresses proliferation of vascular smooth muscle cells through activation of AMP-activated protein kinase. Int J Cardiol. 2014 Aug 20;175: 515-521.