2025
Yi-Chiao Lin, Dinar S. Saputri, Ping-Wei Sun, Chih-Hui Chiu, Hui-Ru Pan, Yin Yin Lau, Chung-Chi Hu, & Hung-Yu Lin. "Monitoring 12 isoflavones during soybean seed germination using LC-MS/MS." Journal of Food Composition and Analysis, Volume 146, 107909. https://doi.org/10.1016/j.jfca.2025.107909
Key Highlights: Developed an optimized LC-MS/MS method to quantify 12 soybean isoflavones within 15 minutes, identifying malonyl-glycosides as the predominant forms during germination.
2020
Yi-Chiao Lin, Chieh-Ju Wu, Ping-Chung Kuo, Wen-Ying Chen, & Jason T. C. Tzen. "Quercetin 3-O-malonylglucoside in the leaves of mulberry (Morus alba) is a functional analog of ghrelin." Journal of Food Biochemistry, 44(9), e13379. https://doi.org/10.1111/jfbc.13379
Key Highlights: Identified quercetin 3-O-malonylglucoside as a functional analog of ghrelin through molecular modeling and bioactivity assays, demonstrating its ability to stimulate growth hormone secretion.
2019
Chieh-Ju Wu, Mei-Yin Chien, Nan-Hei Lin, Yi-Chiao Lin, Wen-Ying Chen, Chao-Hsiang Chen, & Jason T. C. Tzen. "Echinacoside Isolated from Cistanche tubulosa Putatively Stimulates Growth Hormone Secretion via Activation of the Ghrelin Receptor." Molecules, 24(4), 720. https://doi.org/10.3390/molecules24040720
Key Highlights: Investigated echinacoside from Cistanche tubulosa as a non-peptidyl analog of ghrelin, using molecular modeling to show its interaction with the ghrelin receptor.
Yue-Chiun Li, Chieh-Ju Wu, Yi-Chiao Lin, Ruo-Hsuan Wu, Wen-Ying Chen, Ping-Chung Kuo, & Jason T. C. Tzen. "Identification of two teaghrelins in Shy-jih-chuen oolong tea." Journal of Food Biochemistry, 43(5), e12810. https://doi.org/10.1111/jfbc.12810
Key Highlights: Discovered two unique acylated flavonoid tetraglycosides (teaghrelins) in oolong tea that act as oral analogs of ghrelin.