Publications

学術論文 (国際誌・査読有）

2026

A method for reconstituting the motility of membrane-bound myosin on the surface of the cell-sized W/O droplet.

Sato, S., Sumiyoshi, R., Hayashi, M., Yamagishi, M., Yajima, J*.

MethodsX 16, 103755 (2026)

2025

Three-dimensional beating pattern of the ciliary tip in the live ciliate Tetrahymena.

Marumo, A.#, Ishii, H.#, Yamaguchi, S.#, Sumiyoshi, R., Matsuda, K., Yamagishi, M., and Yajima, J*.

Journal of Cell Science 138(20), jcs264027. (2025) https://doi.org/10.1242/jcs.264027

★Press Release くるくる泳ぐ繊毛虫繊毛「1本」の３Dイメージング ─低レイノルズ数環境で生きる微生物の泳ぎ方の理解に向けて─

In vitro motility-based tether-scanning of the kinesin motor domain.

Sumiyoshi, R., Yamagishi, M., and Yajima, J*.

MethodsX 15, 103719 (2025) https://doi.org/10.1016/j.mex.2025.103719

Evidence for motility determinants in the kinesin-1 minimal motor core domain from tether variations.

Sumiyoshi, R., Yamagishi, M., and Yajima, J*

Cytoskeleton (2025) https://doi.org/10.1002/cm.70029

Reconstructing the motility driven by membrane-bound myosin on the inner surface of cell-sized droplets.

Sato, Y., Sumiyoshi, R., Yamagishi, M., Haraguchi, T., K., Matsuda, K., Sato, S., Ito, K., and Yajima, J*.

Langmuir 41, 16, 10077-10084 (2025) https://doi.org/10.1021/acs.langmuir.4c04123

2024

Two Tetrahymena kinesin-9 family members exhibit slow plus-end-directed motility in vitro.

Ishii, H., Yamagishi, M., and Yajima, J*.

Scientific Reports 14: 20993 (2024) https://doi.org/10.1038/s41598-024-71280-y

Tether-scanning the kinesin motor domain reveals a core mechanical action.

Sumiyoshi, R. #, Yamagishi, M. #, Furuta, A., Nishizaka, T., Furuta, K., Cross, R.A.*, and Yajima, J *.

Proc. Natl. Acad. Sci. U S A. 121, e2403739121 (2024) https://doi.org/10.1073/pnas.2403739121

★Press Release バイオナノマシンの運動性の基本原理を実証 ――定説の運動機構を覆しうる発見――

Myosin-induced F-actin fragmentation facilitates contraction of actin networks.

Matsuda, K., Jung, W., Sato, Y., Kobayashi, T., Yamagishi, M., Kim., T *., and Yajima, J*.

Cytoskeleton 81:339-355 (2024) https://doi.org/10.1002/cm.21848

Effect of temperature on actin filament corkscrewing driven by nonprocessive myosin IC.

Sato, Y., Yamagishi, M., Yajima, J*.

Biochem Biophys Res Commun. 703, 149597 (2024) https://doi.org/10.1016/j.bbrc.2024.149597

2023

Membrane-bound myosin IC drives the chiral rotation of the gliding actin filament around its longitudinal axis.

Sato, Y., Yoshimura, K., Matsuda, K., Haraguchi, T., Marumo, A., Yamagishi, M., Sato, S., Ito, K*., and Yajima, J*.

Scientific Reports 13: 19908 (2023) https://doi.org/10.1038/s41598-023-47125-5

2022

Motor generated torque force drives coupled yawing and orbital rotations of kinesin coated gold nanorods.

Sugawa, M*., Maruyama, Y., Yamagishi, M., Cross, R.A., and Yajima, J*.

Communications Biology 5: 1368 (2022) https://doi.org/10.1038/s42003-022-04304-w

Press Release バイオナノマシンチームの螺旋運動の分子機構に迫る ―バイオナノロボの設計に向けて―

Fission yeast Dis1 is an unconventional TOG/XMAP215 that induces microtubule catastrophe to drive chromosome pulling.

Murase, Y., Yamagishi, M., Okada, N., Toya, M., Yajima, J., Hamada, T., and Sato, M,

Communications Biology 5: 1298 (2022) https://doi.org/10.1038/s42003-022-04271-2

Torque generating properties of Tetrahymena ciliary three-headed outer-arm dynein.

Yamaguchi, S. #, Yamagishi, M.#, and Yajima, J*.

Scientific Reports 12: 16722 (2022) https://doi.org/10.1038/s41598-022-21001-0

Anchoring geometry is a significant factor in determining the direction Kinesin-14 motility on microtubules.

Yamagishi, M., Sumiyoshi, R., Drummond, R.D., and Yajima, J*.

Scientific Reports 12: 15417 (2022) https://doi.org/10.1038/s41598-022-19589-4

2021

Three-dimensional tracking of the ciliate Tetrahymena reveals the mechanism of ciliary stroke-driven helical swim ming.

Marumo, A., Yamagishi, M., and Yajima, J*.

Communications Biology 4: 1209 (2021) https://doi.org/10.1038/s42003-021-02756-0

★Press Release くるくる泳ぐ微生物螺旋軌跡の3Dイメージング～マイクロロボットの設計に向けて～

Characterization of the motility of monomeric kinesin-5/Cin8.

Yamagishi, M., Maruyama, Y., Sugawa, M., and Yajima, J*

Biochem Biophys Res Commun. 555: 115-120 (2021) https://doi.org/10.1016/j.bbrc.2021.03.134

CYK4 relaxes the bias in the off-axis motion by MKLP1 kinesin-6.

Maruyama, Y., Sagawa, M., Yamaguchi, S., Davies, T., Osaki, T., Kobayashi, T., Yamagishi, M., Takeuchi, S., Mishima, M.*, and Yajima, J*.

Communications Biology 4: 180 (2021) https://doi.org/10.1038/s42003-021-01704-2

★Press Release バイオナノマシンの運動の左右対称性を破る分子機構に迫る～ミクロな発動分子マシンの設計に向けて～

2020

The N-terminal β-strand of single-headed kinesin-1 can modulate the off-axis force-generation and resultant rotation pitch.

Yamagishi, M., Fujimura, S., Sugawa, M., Nishizaka, T., and Yajima, J*.

Cytoskeleton 77:351-361 (2020) https://doi.org/10.1002/cm.21630

2019

Visualizing dynamic actin cross-linking processes driven by the actin-binding protein anillin.

Matsuda, K., Sugawa, M., Yamagishi, M., Kodera, N.*, and Yajima, J*.

FEBS Letters 594: 1237-1247 (2019) https://doi.org/10.1002/1873-3468.13720

2018

Circular orientation fluorescence emitter imaging (COFEI) of rotational motion of motor proteins.

Sugawa, M., Ma saike, T., Mikami, N., Yamaguchi, S., Shibata, K., Saito, K., Fujii, F., Toyoshima, Y.Y., Nishizaka, T., and Yajima, J*.

Biochem Biophys Res Commun. 504:709-714 (2018) https://doi.org/10.1016/j.bbrc.2018.08.178

2017

Dissection of the angle of single fluorophore attached to the nucleotide in corkscrewing microtubules.

Fujimura, S., Ito, Y., Ikeguchi, M., Adachi, K., and Yajima, J., Nishizaka, T.

Biochem Biophys Res Commun. 485:614-620 (2017) https://doi.org/10.1016/j.bbrc.2017.01.16

2016

Structural Basis of Backwards Motion in Kinesin-1-Kinesin-14 Chimera: Implication for Kinesin-14 Motility.

Yamag ishi, M., Shigematsu, H., Yokoyama, T., Kikkawa, M., Sugawa, M., Aoki, M., Shirouzu, M., Yajima, J.*, and Nitta, R*.

Structure 24:1322-1334 (2016) 10.1016/j.str.2016.05.021

★Press Release 分子モーターの「バックギア」を解明－細胞分裂をつかさどるキネシンが微小管を逆走する仕組み－

Augmin shapes the anaphase spindle for efficient cytokinetic furrow ingression and abscission.

Uehara, R., Kamasaki, T., Hiruma, S., Poser, I., Yoda, K., Yajima, J., Gerlich, D.W., and Goshima, G.

Molecular Biology of the Cell 27: 812-827 (2016) 10.1091/mbc.E15-02-0101

2015

Axonemal dynein light chain-1 locates at the microtubule-binding domain of the γ heavy chain.

Ichikawa, M., Saito. K., Yanagisawa, H., Yagi, T., Kamiya, R., Yamaguchi, S., Yajima, J., Kushida, Y., Nakano, K., Numata, O., and Toyoshima, Y.Y.

Molecular Biology of the Cell 26: 4236-4247 (2015) https://doi.org/10.1091/mbc.e15-05-0289

Torque generation by axonemal outer-arm dynein.

Yamaguchi, S., Saito, K., Sutoh, M., Nishizaka, T., Toyoshima, Y.Y., and Yajima, J*.

Biophysical Journal 108, 872-879 (2015) 10.1016/j.bpj.2014.12.038

2012

Super-resolution imaging of microtubular transport in vitro based on nanoscale localization sampling using nanoantenna arrays.

Kim, K., Yajima, J., Oh, Y., Lee, W., Oowada, S., Nishizaka, T., and Kim, D.

Small 786, 892-900 (2012) https://doi.org/10.1002/smll.201101840

2011

Single-particle tracking of quantum dot-conjugated prion proteins inside yeast cells.

Tsuji, T., Kawai-Noma, S., Pack, C.G., Terajima, H., Yajima, J., Nishizaka, T., Kinjo, M., and Taguchi, H.

Biochem Biophys Res Commun. 405, 638-643 (2011) https://doi.org/10.1016/j.bbrc.2011.01.08

2008

A torque component in mitotic kinesin Eg5 revealed by three-dimensional tracking.

Yajima, J., Mizutani, K., and Nishizaka, T.

Nature Structural & Molecular Biology 15, 1119-1121 (2008) https://doi.org/10.1038/nsmb.1491

2005

A torque component in the kinesin-1 power stroke.

Yajima, J., and Cross, R.A.

Nature Chemical Biology 1, 338-341 (2005) https://doi.org/10.1038/nchembio740

2003

The human chromosome kinesin kid is a plus-end directed microtubule-based motor.

Yajima, J., Nishii, J., Edamatsu, M., Tokai, N., Yamamoto, M., and Toyoshima, Y.Y.

EMBO J, 22, 1067-1074 (2003) https://doi.org/10.1093/emboj/cdg102

A novel action Terpendole E on the motor activity of mitotic kinesin Eg5.

Nakazawa, J., Yajima, J., Usui, T., Ueki, M., Takatsuki, A., Imoto, M., Toyoshima, Y.Y., and Osada, M.

Chemistry & Biology 10, 131-137 (2003) https://doi.org/10.1016/S1074-5521(03)00020-6

2002

Kinesin-microtubule binding depends on both nucleotide state and loading direction.

Uemura, S., Kawaguchi, K., Yajima. J., Edamatsu, M., Toyoshima, Y.Y., and Ishiwata, S.

Proc. Natl. Acad. Sci. U S A. 9, 5977-5981 (2002) https://doi.org/10.1073/pnas.092546199

Direct long-term observation of kinesin processivity at low load.

Yajima, J., Alonso, M., Cross, R., and Toyoshima, Y.Y.

Current Biology 12, 301-306 (2002) https://doi.org/10.1016/S0960-9822(01)00683-2

総説

モーターコアの運動から見えてきたキネシンの動作原理
山岸雅彦、住吉里英子、矢島潤一郎
生物物理 2026年5月
化学フロンティア(23)１分子ナノバイオ化学の新パラダイム
矢島潤一郎 (担当:共著, 範囲:キネシンの運動機構)

化学同人 2014年

細胞骨格のin vitroでの運動を３次元的に追跡する
西坂崇之, 藤村章子, 加藤孝信, 矢島潤一郎
生体の科学 64(6) 558-563 2013年12月
生体分子機械キネシンによる微小管のコークスクリューモーション
矢島潤一郎
生物物理 2009年
細胞と分子モーターの動きを画像化する新しい顕微鏡技術
西坂崇之, 政池知子, 矢島潤一郎
日本マイコプラズマ学会雑誌 2007年5月
モーター分子のメカニズム：1分子の先へ
石渡信一, 上村慎治, 矢島潤一郎
生物物理38(6) 1998年11月

書籍

理系総合のための生命科学第6版
矢島潤一郎 (担当:共著)
羊土社 2026年
物理・化学・数理から理解する生命科学
(担当:分担執筆)
羊土社 2024年3月 (ISBN: 9784758121712)
14歳からの生物学 : 学校では教えてくれない「ヒト」の科学
矢島潤一郎(翻訳・分担)
白水社 2020年9月 (ISBN: 9784560097748)
演習で学ぶ生命科学第2版
矢島潤一郎 (担当:分担執筆)
羊土社 2017年3月
少数性生物学
矢島潤一郎 (担当:共著, 範囲:少数での動き)
日本評論社 2017年
演習で学ぶ生命科学第1版
矢島潤一郎 (担当:共著)
羊土社 2016年3月
理系総合のための生命科学第3版
矢島潤一郎 (担当:共著)
羊土社 2013年3月
理系総合のための生命科学第2版
(担当:共著)
羊土社 2012年

翻訳

Minorities and small numbers from molecules to organisms in biology : toward a new understanding of biological phenomena
2018年 (ISBN: 9789811320828)

読み物

東大教師が新入生にすすめる本

UP　東京大学出版会 2026年4月

バイオナノマシンたちはどう動くか

東京大学教養学部報第658号 2024年11月

くるくるまわりながら進むバイオマシン〜微生物とモータータンパク質を例に〜

東京大学教養学部報第636号 2022年2月

<送る言葉＞　豊島陽子先生を送る

東京大学教養学部報第623号 2020年12月

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