Manuscript in Preparation

Volume expansion history programs an invasive, drug tolerant and immune visible melanoma state

• Zhang X, et al.

• Anticipated submission: January, 2026

Selected Publications

*equal contribution

2023

Compression drives diverse transcriptomic and phenotypic adaptations in melanoma

• Zhang. X, Shi. X, Zhang. D, Gong. X, Wen. Z, Demandel. I, Zhang. J, Rossello, A, Chan. T, Mak. M.

• Proceedings of the National Academy of Sciences

2022

A microfluidic-informatics assay for quantitative physical occlusion measurement in sickle cell disease

• Zhang. X, Shi. X, Zhang. D, Gong. X, Wen. Z, Demandel. I, Zhang. J, Rossello, A, Chan. T, Mak. M.

• Lab on a Chip

2021

Biophysical informatics approach for quantifying phenotypic heterogeneity in cancer cell migration in confined microenvironments

• Zhang. X, Mak. M.

• Bioinformatics

Morphodynamic signatures of MDA-MB-231 single cells and cell doublets undergoing invasion in confined microenvironments

• Zhang. X, Chan. T, Mak. M.

• Scientific Reports

2017

Microvalve controlled multi-functional microfluidic chip for divisional cell co-culture

• LI. R*, Zhang. X*, Lv. X, Geng. L, Qin. K, Deng. Y.

• Analytical Biochemistry

Other Publications

2025

Optimizing T-cell-mediated cancer killing: An agent-based model

• Yu. A, Zhang. X, Munn. L.

• bioRxiv

2023

Volumetric compression shifts rho GTPase balance and induces mechanobiological cell state transition

• Gong. X, Nguyen. R, Chen. Z, Wen. Z, Zhang. X, Mak. M.

• bioRxiv

Self-assembly of mesoscale collagen architectures and applications in 3D cell migration

• Liu. C, Nguyen. R, Pizzurro. G, Zhang. X, Gong. X, Rossello, A, Mak. M.

• Acta biomaterialia

Biophysical informatics reveals distinctive phenotypic signatures and functional diversity of single-cell lineages

• Chan. T, Zhang. X, Mak. M.

• Bioinformatics

2018

Subchondral trabecular rod loss and plate thickening in the development of osteoarthritis

• Chen. Y, Hu. Y, Yu. YE, Zhang. X, Watts. T, Zhou. B, Wang. J, Wang. T, Zhao. W, Chui. KY, Leung. FKL, Cao. X, Macaulay. W, Nishiyama. KK, Shane. E, Lu. WW, Guo. XE.

• Journal of Bone and Mineral Research

2017

Blocking FSH induces thermogenic adipose tissue and reduces body fat

• Liu. P, Ji. Y, Yuen. T, ... ,  Zhang. X, ... , Zaidi. M.

• Nature

2016

A rapidly fabricated microfluidic chip for cell culture

• Li. R, Lv. X, Hasan. M, Xu. J, Xu. Y, Zhang. X, Qin. K, Wang. J, Zhou. D, Deng. Y.

• Journal of Chromatographic Science

Microfluidics for cell-cell interactions: A review

• Li. R, Lv. X, Zhang. X, Deng. Y.

• Frontiers of Chemical Science and Engineering