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Lab News
Jobs openings: Positions in the Yang lab are opening for wet-lab experimental researchers and dry-lab computational programmers to uncover the fascinating nature of mosaicism.
Xiaoxu is editing a Genes special issue "Genomic Mosaicism in Human Development and Diseases".
2025-02-25: Xiaoxu was awarded with a University of Utah Research Instrumentation Fund RIF-006544 as PI.
2025-02-18: Xiaoxu presented a poster titled "Methodologies to reconstruct human early embryonic clonal relationship with mosaic variants" at the Keystone Symposia "Somatic Mosaicism in Human Development, Aging, and Diseases", Breckenridge, CO.
2025-02-13: DeepMosaic v1.1.3 is released, with cram support, new training scripts, and an updated version of singularity container. Great job, Sang!
2025-01-06: Ian Graham joins the lab as a laboratory specialist. Ian received a bachelor's degree in Neuroscience from Lawrence University. Ian continued as a Laboratory Assistant in Progenitor, Lawrence University, and Diabetes and Endocrine Specialists. Welcome, Ian!
2025-01-01: Xincen Xi joins the lab as a student intern. Xincen received a bachelor's degree in Clinical Medicine from Yang Zhou University and MD and MS in Obstetrics and Gynecology from Tongji University. Xincen continued as a Master's Student in Biomedical Informatics at the University of Utah. Read more on LinkedIn. Welcome, Xincen!
2024-12-01: Xiaoxu was invited for a talk titled "Genomic mosaicism and human brain diseases" at the 2024 Chinese Pharmaceutical University Disease Biology Summit.
2024-12: Congrats Muhammad on winning the Asian Journal of Andrology 2024 Outstanding Paper Award with his PhD thesis!
2024-11-19: Xiaoxu presents a talk "Understanding human health and development with genomic mosaicism" at the University of Utah Health Sciences Research Forum.
2024-11-14: Sang Hyun Lee joins the lab as a bioinformatic programmer. Sang received a bachelor's degree in Bioinformatics from the University of California, San Diego. Sang continued as a software developer at Salve Therapeutics focusing on software development and pipeline refinement. Read more on LinkedIn. Welcome, Sang!
2024-11-06: Xiaoxu presented a poster "Board 4115W: Reconstruct Clonal Relationship with Mosaic Variants at Bulk and Single-cell Level " at the American Society of Human Genetics 2024 Annual meeting, Denver, CO.
2024-10-28: Xiaoxu was invited for a lecture "Understand the Origins of Disorders with Genomic Mosaicism" at the DELPHI (Data Exploration and Learning in Precision Health Intelligence) seminar series.
2024-10-21: John Prevedel joins the lab for his 2nd rotation. John received a bachelor's degree in Molecular Biology and Computational Biology from the University of Wyoming. John continued as a Post Baccalaurate Fellow at NICHD before joining the University of Utah for the Molecular Biology PhD program. Read more on LinkedIn. Welcome, John!
2024-10-18: Xiaoxu gave the opening talk "Understanding Human Neural Development with Genomic Mosaicism" at the University of Utah Department of Human Genetics 2024 Retreat.
2024-08-20: Xiaoxu presents the Yang Lab poster at the University of Utah Molecular Biology and Biochemistry Faculty Research Interest Sessions (FRIS), University of Utah.
2024-05-28: Dr. Muhammad Zubair will be joining the lab as a postdoctoral researcher! Muhammad received his PhD in Biological Science from the University of Science and Technology of China. Muhammad's research interest is the mechanisms for male infertility.
2024-04-19: Challenging the Status Quo: Researchers Discover Unique Neuronal Origins in Human Brains, SciTechDaily.
2024: The Yang lab in the Department of Human Genetics, University of Utah at Salt Lake City is officially opened in 2024!
Archived News
2023-12-06: Xiaoxu gave a seminar "Detection of clonal and nonclonal mosaic variants from bulk tissue and single cell genomes" at the CSE290 "Life in Code" at the Department of Computer Science and Engineering, University of California, San Diego.
2023-11-07: Xiaoxu was invited for a talk titled "Understanding human neocortical development through brain somatic mosaicism" at the Capital Medical University Brain Science Research Forum, Chinese Institutes for Medical Research (CIMR), Beijing, on Zoom.
2023-11-03: Xiaoxu was invited for a talk titled "Clonal and non-clonal genomic mosaicism in sperm impact the health of the next generation" together with Drs. Raheleh Rahbari, Molly Przeworski, and Simon Myers for session "Understanding human genetic variation through the lens of germ cell biology" moderated by Drs. Martin Breuss and Anne Goriely at the American Society of Human Genetics 2023 Annual Meeting, Washington, DC, USA.
2023-09-06: Xiaoxu was invited for a talk titled "Understanding Human Human Health and Development from Genomic Mosaicism" at the Neuroscience Seminar Series, Department of Neurosciences, University of California, San Diego.
2023-08-14: Xiaoxu was awarded with the NIH/NIMH R21 award R21MH134401 as MPI with Dr. Johannes CM Schlachetzki.
2023-07-15: Xiaoxu was awarded with the NIH/NICHD K99 Pathway to Independence Award K99HD111686 as PI.
2023-04-10: Researchers Unlock Genetic Mutations Contributing to Disorders in the Brain, NIMH.
2023-03-23: Researchers Identify Cause of Mysterious Cases of Childhood Epilepsy, SciTechDaily.
2023-03-01: Xiaoxu was invited for a talk titled "Mosaic SNV detection with DeepMosaic and mosaicism in malformation of cortical development" at the Department of Pediatrics, Section of Genetics and Metabolism, University of Colorado School of Medicine, Aurora, CO, USA.
2023-01-25: Researchers use supercomputer to unveil new methods for DNA mosaic recognition, AZO Life Sciences.
2023-01-20: DeepMosaic Hopes to Improve Detection of Noncancerous Somatic SNVs, GenomeWeb.
2023-01-12: Computer-generated Models Mimic Human Recognition at Supersonic Speed, San Diego Supercomputer Center.
2023-01-02: New Computer Program ‘Learns’ to Identify Mosaic Mutations That Cause Disease, UC San Diego Today.
2022-10-26: Xiaoxu presented a poster titled "Understanding the burden of clonal and non-clonal sperm mosaicism by bulk and single-cell genome sequencing" at the American Society of Human Genetics 2022 Annual Meeting, Los Angeles, CA, USA.
2022-07-06: Screening Sperm Could Help To Detect Harmful Mutations Before Embryo Implantation, Technology Networks.
2022-07-05: Fertility: Sperm screening might detect harmful mutations before embryo implantation, ScienceDaily.
2022-04-24: Community Newsletter: Tracking cellular origins, autism acceptance, social-communication gains, Spectrum News.
2022-04-20: For Neurons, Where They Begin Isn’t Necessarily Where They End, news wise.
2021-11-02: Xiaoxu presented a lecture titled "Preventing Genetic Disease due to De Novo Mutations through Analysis of Parental Mosaicism" at the Rady Children's Institute of Genomic Medicine Report Seminar.
2021-10-21: Xiaoxu gave a platform presentation titled "Understanding clonal distributions during human cortical development deciphered through brain somatic mosaicism", Session 39 "Mechanisms of fetal CNS development", at the American Society of Human Genetics 2021 Virtual Annual Meeting.
2021-09-29: Researchers Discover Unknown Childhood Genetic Condition and its Potential Cure, UC San Diego Health.
2021-09-25: Xiaoxu gave an invited talk titled "Temporal stability of human clonal sperm mosaicism results in life-long threat of transmission to offspring" together with Michael Kessler, Amelia Wallace as Symposium 06 "Germ Cell Mutation and Developmental Mosaicism: Potential Health Implications" chaired by Jonathan Axelsson, Carole Yauk, and Danielle LeBlanc, at the Environmental Mutagenesis and Genomics Society 2021 Virtual Annual Meeting.
2021-09-16: Mutations linked to autism may be detectable in men’s sperm, Spectrum News.
2021-09-03: Xiaoxu was invited for a talk titled "Sperm mosaicism and it's genetic implications" by the BioArt Research Forum.
2021-08-16: One in 15 men have sperm mutations that could cause childhood disease, study suggests, yahoo! news.
2021-08-14: Mutations in sperm of older men can pass health disorders onto their children, study finds, Daily Mail.
2021-08-12: Human Sperm Mutations that Can Cause Disease in Children Identified, UC San Deigo Daily.
2020-10-28: Xiaoxu gave a poster presentation titled "DeepMosaic: Control-independent detection of mosaic single nucleotide variants through deep convolutional neural networks" at the American Society of Human Genetics 2020 Virtual Annual Meeting.
2020-09-14: Xiaoxu gave a poster presentation titled "Genetic features of focal cortical dysplasia via ultra-deep targeted mTOR pathway sequencing" at the Frontiers in Pediatric Genomic Medicine Virtual Conference.
2019-12-26: Measuring Mutations in Sperm May Reveal Risk for Autism in Future Children, Neuroscience News.
2018-11-08: Xiaoxu gave a platform presentation titled "Brain somatic mosaicism in focal cortical dysplasia" at the 2018 Brian Somatic Mosaicism Network in-person workshop, San Diego, CA, USA.
2017-10-18: Xiaoxu gave a platform presentation titled "Deep amplicon resequencing identified parental mosaicism for approximately 10% 'de novo' SCN1A mutations in Dravet Syndrome families and was capable of multiple validations of mosaicism" with Rebecca Torene, Mari Tokita, Sangmoon Lee, Hannah Ralph, and Yasminka Jakubek during Session 12 "Detection and Impact of Mosaicism in Human Disease" moderated by James Bennett and Gemma Carvill at the American Society of Human Genetics 2017 Annual Meeting, Orlando, FL, USA.
2017-09-04: Xiaoxu gave a platform presentation titled "Genomic mosaicism in paternal sperm and multiple parental tissues from Dravet syndrome cohort" at the Peking University School of Life Sciences 2017 Academic Week, Beijing, China.
2015-09-07: Xiaoxu gave a platform presentation titled "Approximately 10% of 'de novo' SCN1A mutations causing Dravet Syndrome are inherited from undetected parental mosaicism" with Gemma Carvill, Rikke Møller, Carolien de Kovel, and Leanne Dibbens, at the Genetics Session 2 chaired by Jamie Carrizosa at the 31st International Epilepsy Congress, Istanbul, Turkey.
