Metabolic & Biomedicine Lab

Zebrafish Adult & Embryos

Zebrafish share conserved metabolic pathways with mammals, developing a functional liver, pancreas, and intestine within days. Transparent larvae allow live visualization of fat deposition, neurological behaviour and glucose dynamics provides a unique among vertebrate models. Mutant and transgenic lines readily recapitulate obesity, fatty liver, and type 2 diabetes phenotypes, and high fecundity enables large-scale drug screening at low cost. 

Rodent models

Mice share ~85% genomic similarity with humans and closely mimic human metabolic physiology. Diet-induced and genetic models reliably develop obesity, diabetes, and fatty liver, with decades of validated metabolic phenotyping tools — making them the most translatable vertebrate model for metabolic disease research. 

Mammalian cell lines

Mammalian cell lines provide a controlled, cost-effective system to dissect cell-autonomous mechanisms metabolism and insulin signaling. Classic lines such as 3T3-L1 (adipocytes), HepG2 (hepatocytes), L6 (muscle), Keratinocytes etc. closely mimic key metabolic tissues, enabling high-throughput gene knockdown, drug treatment, and in vitro mechanistic studies.

Computational studies

We use computational approaches including molecular docking and network pharmacology to predict compound-target interactions and support experimental findings.