WELCOME TO SEO's LAB


"Leading the fight against microbial infection"

Our lab is on a mission to understand how our bodies defend themselves, with a keen interest in the diversity of innate immune cells. We're also contributing to the epidemiology and vaccine development against viral diseases in Korea.

Innate Immune Cells -  More Diverse Than We Expected!!!


In the dynamic arena of our body's defense mechanisms, innate immune cells take center stage, playing a pivotal role in the early part of fighting infections and sparking inflammation. Among the stars of this intricate system are the Monocyte, Neutrophil, and Eosinophil, each with its unique talents and contributions to our well-being. 

One of the most inspiring aspects of innate immunity is its ability to continuously regenerate. Born in the bone marrow and other hematopoietic organs, these cells are endlessly produced and deployed to the frontline. What makes them truly remarkable, though, is their adaptability; depending on the type of pathogen invading or the progress of a disease, characteristics of innate immune cells can dramatically shift. 


This constant flux means that from the moment an infection begins to the time it's vanquished, our bodies are supplied with a stream of innate immune cells, each batch sporting different features. The diversity among these cells is staggering, a testament to the body's complex strategy for protection. 


To unravel the mysteries of these ever-changing warriors, we've turned to cutting-edge single-cell analysis techniques. This approach has shone a light on how innate immune cells morph in response to disease, providing us with unprecedented insights into their versatility and critical role in our health. Through this lens, we're beginning to appreciate the vast landscape of our immune system's first responders, more diverse and dynamic than we ever imagined. 


Vaccines - Engineering Immunity, Defending Humanity 


Our immune system learn and remember through 'antigen,' the immune-inducing substance, thereby gearing up to combat pathogens. This innate capability, understood even in times when the concept of immunity was yet to be clearly defined, led our ancestors to realize that surviving a disease often granted a natural resistance against it. By artificially inducing this learning process, vaccines empower our immune system to preemptively fight diseases without having to endure their full brunt. 


Advancing through the ages, vaccine development has transformed into a highly sophisticated field, leveraging the latest in scientific and engineering innovations. In our laboratory, we contribute to this evolution by focusing on nano-sized engineered particles that carry viral antigens, aiming to develop the next generation of vaccines. 

Building on this foundation, our team has recently undertaken vaccine development projects targeting the Japanese encephalitis virus and SARS-CoV-2. This initiative has not only marked a significant stride in our research but has also enabled us to establish a robust system for preclinical studies involving animal testing. 


Our laboratory aims to evolve into an institution that not only excels in foundational research but also takes pride in developing vaccines that have a tangible impact on people's well-being, fulfilling our mission to safeguard and enhance public health through scientific innovation. 

Selected Publications













 




Location

Address 

Omnibus Park Building A, Room 8108  222, Banpo-daero, Seocho-gu, Seoul Special City, South Korea (Department of Microbiology ) 

서울특별시 서초구 반포동 반포대로 222 옴니버스파크 / TEL : 02-3147-8114 / FAX : 02-532-6537

Omnibus Park building A 222 Banpo-daero Seocho-gu, Seoul, korea (06591)  / TEL : +82-2-3147-8114 / FAX : +82-2-532-6537