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"Leading the fight against microbial infection"
Our lab is on a mission to understand how our bodies defend themselves, with a keen interest in the diversity of innate immune cells. We're also contributing to the epidemiology and vaccine development against viral diseases in Korea.
Innate Immune Cells - More Diverse Than We Expected!!!
In the dynamic arena of our body's defense mechanisms, innate immune cells take center stage, playing a pivotal role in the early part of fighting infections and sparking inflammation. Among the stars of this intricate system are the Monocyte, Neutrophil, and Eosinophil, each with its unique talents and contributions to our well-being.
One of the most inspiring aspects of innate immunity is its ability to continuously regenerate. Born in the bone marrow and other hematopoietic organs, these cells are endlessly produced and deployed to the frontline. What makes them truly remarkable, though, is their adaptability; depending on the type of pathogen invading or the progress of a disease, characteristics of innate immune cells can dramatically shift.
This constant flux means that from the moment an infection begins to the time it's vanquished, our bodies are supplied with a stream of innate immune cells, each batch sporting different features. The diversity among these cells is staggering, a testament to the body's complex strategy for protection.
To unravel the mysteries of these ever-changing warriors, we've turned to cutting-edge single-cell analysis techniques. This approach has shone a light on how innate immune cells morph in response to disease, providing us with unprecedented insights into their versatility and critical role in our health. Through this lens, we're beginning to appreciate the vast landscape of our immune system's first responders, more diverse and dynamic than we ever imagined.
Vaccines - Engineering Immunity, Defending Humanity
Our immune system learn and remember through 'antigen,' the immune-inducing substance, thereby gearing up to combat pathogens. This innate capability, understood even in times when the concept of immunity was yet to be clearly defined, led our ancestors to realize that surviving a disease often granted a natural resistance against it. By artificially inducing this learning process, vaccines empower our immune system to preemptively fight diseases without having to endure their full brunt.
Advancing through the ages, vaccine development has transformed into a highly sophisticated field, leveraging the latest in scientific and engineering innovations. In our laboratory, we contribute to this evolution by focusing on nano-sized engineered particles that carry viral antigens, aiming to develop the next generation of vaccines.
Building on this foundation, our team has recently undertaken vaccine development projects targeting the Japanese encephalitis virus and SARS-CoV-2. This initiative has not only marked a significant stride in our research but has also enabled us to establish a robust system for preclinical studies involving animal testing.
Our laboratory aims to evolve into an institution that not only excels in foundational research but also takes pride in developing vaccines that have a tangible impact on people's well-being, fulfilling our mission to safeguard and enhance public health through scientific innovation.
Selected Publications
Lee AR, Kim WJ, Choi H, Kim SH, Hong SY, Shim SM, Lee HI, Song JM, Kim SJ, Ishikawa T, Kang JM, Eom HS, Seo SU*. Genotype III-Based Japanese Encephalitis Vaccines Exhibit Diminished Neutralizing Response to Reemerging Genotype V. J Infect Dis. 2025 Jun 2;231(5):1281-1289. (*Corresponding authors)
Kim WJ, Lee AR, Hong SY, Kim SH, Kim JD, Kim SJ, Oh JS, Shim SM, Seo SU*. Characterization of a Small Plaque Variant Derived from Genotype V Japanese Encephalitis Virus Clinical Isolate K15P38. J Microbiol Biotechnol. 2024 Aug 28;34(8):1592-1598. (*Corresponding authors)
Lee AR, Kim SH, Hong SY, Lee SH, Oh JS, Lee KY, Kim SJ, Ishikawa T, Shim SM, Lee HI, Seo SU*. Characterization of genotype V Japanese encephalitis virus isolates from Republic of Korea. Emerg Microbes Infect. 2024 Dec;13(1):2362392 (*Corresponding authors)
Kim JD, Lee AR, Moon DH, Chung YU, Hong SY, Cho HJ, Kang TH, Jang YH, Sohn MH, Seong BL*, Seo SU*. Efficacy of Genotype-matched Vaccine Against Re-emerging Genotype V Japanese Encephalitis Virus. Emerg Microbes Infect. 2024 Dec 13(1):2343910. (*Corresponding authors)
Zou Y, Kamada N, Seong SY*, Seo SU*. CD115- monocytic myeloid-derived suppressor cells are precursors of OLFM4high polymorphonuclear myeloid-derived suppressor cells. Commun Biol, 2023, 6(1):272. (*Corresponding authors)
Pandit M, Timilshina M, Gu Y, Archarya S, Chung Y, Seo SU*, Chang JH*. AMPK suppresses Th2 cell responses by repressing mTORC2. Exp Mol Med, 2022, 54(8):1214-1224. (*Corresponding authors)
Lee AR, Song JM, Seo SU*. Emerging Japanese encephalitis virus genotype V in Republic of Korea. J Microbiol Biotechnol, 2022, 32(8):955-959. (*Corresponding author)
Seo SU*, Seong BL. Prospects on repurposing a live attenuated vaccine for the control of unrelated infections. Front Immunol, 2022. 13:877845. (*First authors)
Kim C, Kim JD, Seo SU*. Nanoparticle and virus-like particle vaccine approaches against SARS-CoV-2. J Microbiol, 2022, 60(3):335-346. (*Corresponding author)
Seo SU*, Jeong JH*, Baek BS, Choi JM, Choi YS, Ko HJ, Kweon MN. Bleomycin-induced lung injury increases resistance to influenza virus infection in a type I interferon-dependent manner. Front Immunol, 2021, 12:697162. (*First authors)
Lim J, Cheong Y, Kim YS, Chae W, Hwang BJ, Lee J, Jang YH, Roh YH*, Seo SU*, Seong BL*. RNA-dependent assembly of chimeric antigen nanoparticles as an efficient H5N1 pre-pandemic vaccine platform. Nanomedicine, 2021, 37:102438. (*Corresponding authors)
Hyun YM*, Seo SU*, Choi WS, Kwon HJ, Kim DY, Jeng S, Kang GY, Yi E, Kim M, Ryu HJ, Looney MR, Choi EY, Kim HS. Endogenous DEL-1 restrains melanoma lung metastasis by limiting myeloid cell-associated lung inflammation. Sci Adv, 2020, 6(45):eabc4882. (*First authors)
Jung JH, Hong HJ, Gharderpour A, Cho JY, Baek BS, Hur Y, Kim BC, Kim D, Seong SY, Lim JY*, Seo SU*. Differential interleukin-1b induction by uropathogenic Escherichia coli correlates with its phylotype and serum C-reactive protein levels in Korean infants. Sci Rep, 2019, 9(1):15654. (*Corresponding authors)
Kim D, Kim YM, Kim WU, Park JH, Nunez G, Seo SU*. Recognition of the microbiota by Nod2 contributes to the oral adjuvant activity of cholera toxin through the induction of Interleukin-1b. Immunology, 2019, 158(3):219-229. (*Corresponding author)
Seo SU*, Kweon MN*. Virome-host interactions in intestinal health and disease. Curr Opin Virol, 2019, 37:63-71. (Invited review article, *Corresponding authors)
Seo SU*, Kuffa P, Kitamoto S, Nagao-Kitamoto H, Rousseau J, Kim YG, Puente JL, Núñez G, Kamada N. Intestinal macrophages control pathogen infection by activating innate lymphoid cells through caspase-11-mediated IL-1b production. Nat Commun, 2015, 6:8010. (*First authors)
Seo SU*, Kamada N, Muñoz-Planillo R, Kim YG, Kim D, Koizumi Y, Hasegawa M, Himpsl SD, Browne HP, Lawley TD, Mobley HL, Inohara N, Núñez G. Distinct commensals induce interleukin-1b via NLRP3 inflammasome in inflammatory monocytes to promote intestinal inflammation in response to injury. Immunity, 2015, 42(4):744-755. (*First authors)
Kamada N, Seo SU, Chen GY, Núñez G. Role of the gut microbiota in immunity and inflammatory disease. Nat Rev Immunol, 2013, 13(5):321-335.
Seo SU*, Kwon HJ, Ko HJ, Byun YH, Seong BL, Uematsu S, Akira S, Kweon MN. Type I interferon signaling regulates Ly6Chi monocytes and neutrophils during acute viral pneumonia in mice. PLoS Pathog, 2011, 7(2):e1001304. (*First authors)
Location
Address
Omnibus Park Building A, Room 8108 222, Banpo-daero, Seocho-gu, Seoul Special City, South Korea (Department of Microbiology )
서울특별시 서초구 반포동 반포대로 222 옴니버스파크 / TEL : 02-3147-8114 / FAX : 02-532-6537
Omnibus Park building A 222 Banpo-daero Seocho-gu, Seoul, Korea (06591) / TEL : +82-2-3147-8114 / FAX : +82-2-532-6537
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