Our major research interest focuses on spreading depolarization, which is a severe neurological condition following acute brain injuries and contributes to poor outcomes in patients. We try to understand the neurophysiological mechanisms by which spreading depolarization causes abnormal neural functions and how it induces brain damage. We are also interested in finding therapeutic strategies for preventing spreading depolarization-associated pathological responses of the brain. Another topic of our research involves the functional interaction between neurons and glial cells. The dysfunction of neuron-glia communication may contribute to impaired neuronal function in diseases. Our lab applies techniques including two-photon laser-scanning microscopy, patch-clamp recordings, in vivo electrophysiological recordings, molecular and biochemical approaches.