Our major research interest concerns the alteration of inhibitory synaptic transmission in neurological diseases. Our research involves the relation between molecular structural modulation and functional changes in glycine and GABA_A receptors. Genetic deficits of these receptors could cause neurological diseases, including hyperekplexia, epilepsy, and autism. We are also interested in exploring novel drugs targeting on GABA_A and glycine receptors. Our lab applies techniques including patch-clamp recordings, molecular biology, biochemical approaches and behavior tests.