Meg is one of the main protagonists. She struggles to conform to the norm. She learns she can save her father and tries hard.

Calvin is a main protagonist. He wants to have a loving family. He goes with Meg to help the universe.

Charles Wallace is another Main Protagonist and also an antagonist. When he is good he wants to help Meg. When he is bad he wants stop Meg and help IT.

He is an antagonist and a bit like a stagehand of sorts to IT. He brainwashes Charles.

Ms. Whatsit is a protagonist. She is one of the 3 Ms. She is the youngest and least wise. (for reference she is pretty wise)

Ms. Who is the 2nd oldest and she and she quotes a lot. She is very wise but not as much as Ms. Witch.

Ms. Witch is a protagonist. She is the 3rd Ms. She is the oldest and wisest.