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Research
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Exploring the metabolome: Insights into host-microbe interactions and their biological significance
Exploring the metabolome: Insights into host-microbe interactions and their biological significance
Our research investigate the complex interplay between host organisms and their microbiota, emphasizing metabolic interaction and its impact on health and disease. We utilize untargeted metabolomics to analyze mouse and human tissue samples collected from various disease models and gnotobiotic mice. This comprehensive approach allows us to capture a wide range of metabolites produced by both the host and its associated microorganisms. Our objectives include identifying and characterizing metabolites produced during host-microbe interactions, investigating the impact of specific microbial communities on host metabolism, elucidating the role of microbial metabolites in health and disease, and developing potential therapeutic strategies based on modulating the host-microbe metabolome. Check out our recent paper in Nature.
Our research investigate the complex interplay between host organisms and their microbiota, emphasizing metabolic interaction and its impact on health and disease. We utilize untargeted metabolomics to analyze mouse and human tissue samples collected from various disease models and gnotobiotic mice. This comprehensive approach allows us to capture a wide range of metabolites produced by both the host and its associated microorganisms. Our objectives include identifying and characterizing metabolites produced during host-microbe interactions, investigating the impact of specific microbial communities on host metabolism, elucidating the role of microbial metabolites in health and disease, and developing potential therapeutic strategies based on modulating the host-microbe metabolome. Check out our recent paper in Nature.
Integrating genome editing and metabolomics in microbial natural product discovery
Integrating genome editing and metabolomics in microbial natural product discovery
We focus on identifying and characterizing novel metabolites from bacteria and fungi through genetic manipulation of biosynthetic gene clusters. We employ metabolomics based on HPLC-HRMS for precise identification of metabolites, followed by NMR spectroscopy analysis. Our research encompasses the analysis of biosynthetic pathways using advanced techniques such as comparative metabolomics, molecular networking, and isotope labeling studies. By integrating genomic, transcriptomic, and metabolomic data, we aim to elucidate complex biosynthetic routes leading to novel metabolites. This comprehensive approach enables us to uncover new bioactive compounds, investigate their biosynthetic pathways, and explore their potential pharmaceutical applications. Check out our recent paper in Nature Communications.
We focus on identifying and characterizing novel metabolites from bacteria and fungi through genetic manipulation of biosynthetic gene clusters. We employ metabolomics based on HPLC-HRMS for precise identification of metabolites, followed by NMR spectroscopy analysis. Our research encompasses the analysis of biosynthetic pathways using advanced techniques such as comparative metabolomics, molecular networking, and isotope labeling studies. By integrating genomic, transcriptomic, and metabolomic data, we aim to elucidate complex biosynthetic routes leading to novel metabolites. This comprehensive approach enables us to uncover new bioactive compounds, investigate their biosynthetic pathways, and explore their potential pharmaceutical applications. Check out our recent paper in Nature Communications.
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