Publications

Recent Publications

• Shih-Cheng Chen, Cui-Ting Xu, Chuan-Fu Chang, Chia-Shin Yang*, Pin-Han Lin, Wei-Min Liu, Yeh Chen*,and Chien-Hung Yu* “Characterization of the binding features between SARS-CoV-2 5’-proximal transcripts of genomic RNA and nucleocapsid proteins” RNA Biology 2025, 22, 1-16

• Lavanya Chandrasekar, James P. Flood, Yo-Cheng Chang, Evonne Liu, Kenneth Zhang, Feng Li* & Wei-Min Liu* “Synthesis and structure of a new ‘hybrid’ β-diketonato coumarin-chalcone ligand“ J. Incl. Phenom. Macrocycl. Chem. (2025) doi.org/10.1007/s10847-025-01284-2

• Pin-Han Lin, Guan-Wei Wu, Yu-Hao Lin, Jing-Rou Huang, U-Ser Jen, Wei-Min Liu* and Jie-Rong Huang* “TDP-43 Amyloid Fibril Formation via Phase Separation-Related and 2 -Unrelated Pathways“ ACS Chem. Neurosci. 2024, 15, 3767-3775

• Lavanya Chandrasekar, Yun-Zhen Hsieh, Hao-Tse Chou, Yu-Chen Huang, and Wei-Min Liu* “Synthesis of Alkynyl Cyclopropa[c]coumarins via Propargyl Sulfonium Salts as C1 Synthons” Org. Biomol. Chem. 2024, 22, 9219-9230

• Ai-Ci Chana, Pei-Ya Shan, Men-Hsin Wu, Pin-Han Lin, Chang-Shun Tsai, ChiaChien Hsu, Ting-Wei Hsu, Yi-Cheun Yeh, Yun-Ju Lai*, Wei-Min Liu*, and Ling-Hsien Tua *  "Piperic acid derivative as a molecular modulator to accelerate IAPP aggregation process and alter its antimicrobial activity "  Chem. Comm. 2023 59, 10660-10663

• Hui-Hsuan Yu, Pin-Han Lin, Zhao-Bin Chen, Zhi-Wen Chen, Yen-Jen Chen, Wei-Min Liu,* and Ching-Ping Liu* "Molecular Engineering to Boost the Photo-oxidase Activity of Molecular Rotors in Colorimetric Sensing of Temperatures"  Eur. Chem. J. 2023, e202301591

• Han-Yu Chen, Chung-Siang Teng, Pin-Han Lin, Ching-Ping Liu, Wei-Min Liu*, and Li-Kang Chu* "Noncovalent Association Thermodynamics of Turn-on Fluorescent Probes with Human Serum Albumin: Dual-concentration Ratio Method"  ChemBioChem. 2023, e20230

• Yu-Hsuan Wu, Yu-Pei Chang, Chia-Chien Hsu, Yi-Lun Chen, Pin-Han Lin, Ting-Wei Hsu, Wei-Min Liu, Yun-Ju Lai, Mei-Yi Liao*, Ling-Hsien Tu* "Synthesis of Fe3O4-Chlorophyllin Nanoparticles for Preventing Amyloid Formation by Human Calcitonin" ACS Appl. Nano Mater. 2023, 6, 12598-12608

• Ya-Chu Ku†, Pin-Han Lin†, Chung-Yu Huang, Chia-Wei Lee, Chien-Hung Yu, Shih-Cheng Chen* and Wei-Min Liu* "An iminocoumarin based covalent-assembly red-emitting fluorescent probe for detection of β-galactosidase activity in ovarian cancer cells" Dyes Pigm. 2023, 210, 111004 

• Pin-Han Lin†, Chang-Shun Tsai†, Chia-Chien Hsu, I-Ren Lee, Yu-Xin Shen, Hsiu-Fang Fan, Yun-Wen Chen*, Ling-Hsien Tu* and Wei-Min Liu* "An environmentally sensitive molecular rotor as a NIR fluorescent probe for the detection of islet amyloid polypeptide " Talanta, 2023, 254, 124130

• Shih-Ting Ma, Chia-Wei Lee and Wei-Min Liu* “Synthesis of 4-thiol-furanosidic uronate via hydrothiolation   reaction” RSC Adv., 2021, 11, 18409.

• Kuan-Hsuan Su, Chin-Teng Wu, Shang-Wei Lin, Seiji Mori, Wei-Min Liu*, and Hsiao-Ching Yang* “Calculation of CYP450 protein–ligand binding and dissociation free energy paths” J. Chem. Phys., 2021, 155, 025101.

• W.-L. Chen; S.-T. Ma; Y.-W. Chen; Y.-C. Chao; A.-C. Chan; L.-H. Tu* and W.-M. Liu* “A Fluorogenic Molecule for Probing Islet Amyloid Using Flavonoid as a Scaffold Design” Biochemistry 2020, 59, 1482-1492.

• 詹璦綺, 林品菡, 劉維民*, 杜玲嫻* “螢光小分子用於偵測類澱粉蛋白聚集” 化學 2020年，第七十八卷，35-47 頁

• Miao, Q.; Liu, W.-M.; Kock, T.; Blok, A.J.; Timmer, M.; Overhand, M. & Ubbink, M＊“A double-armed, hydrophilic, transition metal complex as paramagnetic NMR probe” Angew. Chem. Int. Ed. 2019, 131, 13227-13234. 

• Y.Y. Dong; H. Wang; A.C.W. Pike; S.A. Cochrane; S. Hamedzadeh; F.J. Wyszyński; S.R. Bushell; S.F. Royer; D.A. Widdick; A. Sajid; H.I. Boshoff; Y. Park; R. Lucas; W-M. Liu; S.S. Lee; T. Machida; S. Mehmood; K. Belaya; W. Liu; A. Chu; L. Shrestha; S.M. Mukhopadhyay; N. Burgess-Brown; M.J. Bibb; C.E. Barry; C.V. Robinson; D. Beeson; B.G. Davis＊ and E.P. Carpenter＊“Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design” Cell 2018, 175, 1045-1058.

• Andralojc, W.; Hiruma, Y.; Liu, W. –M,; Ravera E.; Nojiri M.; Parigi G.; Luchinat C. and Ubbink M＊ “Identification of productive and futile encounters in an electron transfer protein complex“ Proc. Natl. Acad. Sci. U. S. A., 2017, 114, E1840-E1847.

• Jesika Schilder, Wei-Min Liu, Pravin Kumar, Mark Overhand, Martina Huber and Marcellus Ubbink＊“Protein docking using an ensemble of spin labels optimized by intra-molecular paramagnetic relaxation enhancement” Phys. Chem. Chem. Phys., 2016, 18, 5729-5742

Book Chapter:

• Ru-Yi Youh, Po-Yen Chen, Yen-Cheng Chao, Di-Hua Luo, Hao-Hsiang Chang, Yu-Ling Chang, Wei-Min Liu*, Dean Chou*; Chapter 9: Biomarkers and Applications in Alzheimer’s Disease “Frontiers in Nanobiotechnology Vol. 1, Advances in Biosensing Technology for Medical Diagnosis” Benthem Book

Before FJCU

• Skinner, S. P.; Liu, W. –M.; Hiruma, Y.; Timmer, M.; Blok, A.; Hass, M. A. S.; Ubbink, M.＊“The delicate conformational balance of the redox enzyme cytochrome P450cam” Proc. Natl. Acad. Sci. U. S. A., 2015, 112, 9022-9027.

• Hass, M. A. S.; Liu, W.-M.; Agafonov, R. V.; Otten, R.; Phung, L. A.; Jesika T. Schilder, J. T.; Kern, D.; Ubbink, M.＊“A minor conformation of a lanthanide tag on adenylate kinase characterized by paramagnetic relaxation dispersion NMR spectroscopy” J. Biomol. NMR 2015, 61, 123-136.

• Camacho-Zarco, Aldo R.; Munari, F.; Wegstroth, M.; Liu, W.-M.; Ubbink M.; Becker, S.; Zweckstetter, M＊ “Multiple Paramagnetic Effects through a Tagged Reporter Protein” Angew. Chem. Int. Ed. 2015, 54, 336-339.

• Liu, W. –M.; Overhand, M.; Ubbink, M.＊ “The application of paramagnetic lanthanoid ions in NMR spectroscopy on proteins” Coord. Chem. Rev. 2014, 273, 2-12.

• Liu, W. –M.; Skinner, S. P.; Timmer, M.; Blok, A.; Filippov, D.; Overhand, M.; Ubbink, M.＊ “A two-armed lanthanoid-chelating paramagnetic NMR probe linked to proteins via thioether linkages” Chem. Eur. J. 2014, 20, 6256-6258.

• Hiruma, Y.; Hass, M. A. S.; Kikui, Y.; Liu, W. –M.; Olmez, B.; Skinner, P. S.; Blok, A.; Kloosterman, A.; Koteishi, H.; Loehr, F.; Schwalbe, H.; N­ojiri, M.; Ubbink, M.＊ “The Structure of the Cytochrome P450cam-Putidaredoxin Complex Determined by Paramagnetic NMR Spectroscopy and Crystallography” J. Mol. Biol., 2013, 22, 4353-4365.

• Guan, J.-Y.; Keizers, P. H. J.; Liu, W. –M.; Loehr, F.; Skinner, S. P.; Heeneman, E. A.; Schwalbe, H.; Ubbink, M.＊ and Siegal, G. D.＊ “Small molecule binding sites on proteins established by paramagnetic NMR spectroscopy” J. Am. Chem. Soc. 2013, 135, 5859-5868.

• Liu, W. –M.; Keizers, P. H. J.; Hass, M. A. S.; Blok, A.; Timmer, M.; Sarris, A. J. C.; Overhand, M.; Ubbink, M.＊ “A pH-sensitive, Colorful, Lanthanide-chelating Paramagnetic NMR Probe” J. Am. Chem. Soc. 2012, 134, 17306-17313.

• Dasgupta, S.; Hu, X.; Keizers, P. H. J.; Liu, W. –M.; Luchinat, C.; Nagulapalli, M.; Overhand, M.; Parigi, G.; Sgheri, L.; Ubbink, M.＊ “Narrowing the conformational space sampled by two domain proteins with paramagnetic probes in both domains” J. Biomol. NMR 2011, 51, 253-263.