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Our research interests are centered around exploring the intricate relationship between the gut microbiota and the regulation of emotion through the gut-brain axis. We are particularly interested in understanding how specific gut microbiota species and their metabolites can influence social behavior, anxiety, innate behaviors, and stress responses. To achieve this, we employ a combination of techniques from neuroscience and microbiology, including imaging, chemogenetics, electrophysiology, microbiome analysis, antibiotic treatment, live-bacteria treatment, fecal microbiota transplant, and behavioral analysis. Our current work focuses on investigating how specific gut microbiota modulates neural circuits and brain function to influence emotional-related behavior and physiology in mouse.
Our research interests are centered around exploring the intricate relationship between the gut microbiota and the regulation of emotion through the gut-brain axis. We are particularly interested in understanding how specific gut microbiota species and their metabolites can influence social behavior, anxiety, innate behaviors, and stress responses. To achieve this, we employ a combination of techniques from neuroscience and microbiology, including imaging, chemogenetics, electrophysiology, microbiome analysis, antibiotic treatment, live-bacteria treatment, fecal microbiota transplant, and behavioral analysis. Our current work focuses on investigating how specific gut microbiota modulates neural circuits and brain function to influence emotional-related behavior and physiology in mouse.
Techniques used in the lab
Techniques used in the lab
Project 1: Neural circuits in gut-brain bidirectional communication
Project 1: Neural circuits in gut-brain bidirectional communication
Investigate the brain regions responded to gut microbiota
Neurotracing approach in brain regions involved in gut-brain axis
Project 2: Gut microbiota in stress regulation
Project 2: Gut microbiota in stress regulation
Project 3: Gut microbiota in threat response
Project 3: Gut microbiota in threat response
Project 4: Gut microbiota in autism spectrum disorder (ASD)
Project 4: Gut microbiota in autism spectrum disorder (ASD)
Identify the gut bacteria regulate ASD-like behavior in mouse
Identify the gut bacterial metabolite in controlling ASD-like behavior in mouse
Test the probiotic therapy in model of ASD
The impact of early-life antibiotics exposure on microbiome and autistic-like behavior development
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