Publication

PUBLICATIONS

* corresponding author

1. Griffiths JA*, Nirmalkar K, Wu WL, Krajmalnik-Brown R, Mazmanian SK*. The gut microbiome shapes social behaviour across animal species. Nat Rev Microbiol. 2025 Nov 14. doi: 10.1038/s41579-025-01262-y. Epub ahead of print. PMID: 41238755.

2. Lin CH*, Wu WL*. Brain hacks: Engineering a microbial factory for Parkinson’s disease. Cell Host Microbe. 2025 Nov 12;33(11):1834-1836. doi: 10.1016/j.chom.2025.10.008. PMID: 41232520.

•  In Translation article for Padhi P, Abdalla A, Schneider B, Backes N, Otto AA, Scheibe IJ, Thomas JP, Khadse G, Samidurai M, Jochmans AK, George A, Zenitsky G, Jin H, Anantharam V, Kanthasamy A, Mishra A, Allenspach K, Mochel J, Phillips GJ, Kanthasamy AG. Bioengineered gut bacterium synthesizing levodopa alleviates motor deficits in models of Parkinson's disease. Cell Host Microbe. 2025 Oct 30:S1931-3128(25)00419-6. doi: 10.1016/j.chom.2025.10.005. Epub ahead of print. PMID: 41172985. 

3. Lai TT, Tsai YH, Liou CW, Fan CH, Hou YT,  Yao TH, Chuang HL, Wu WL*. The gut microbiota modulate locomotion via vagus-dependent glucagon-like peptide-1 signaling. NPJ Biofilms Microbiomes. 2024 Jan 16;10(1):2. doi: 10.1038/s41522-024-00477-w. PMID: 38228675; PMCID: PMC10791613.

學生作者：賴姿廷 (第一作者)、蔡于宣 (共同第二作者)、劉嘉瑋 (共同第二作者)、姚子宣

• SpringerNature Research Communities Blog Post/Behind the paper: New research unveiling the invisible puppeteers: how our gut microbiota pulls the strings on host locomotion.

4. Lai TT, Liou CW, Tsai YH, Lin YY, Wu WL*. Butterflies in the gut: the interplay between intestinal microbiota and stress. J Biomed Sci. 2023 Nov 28;30(1):92. doi: 10.1186/s12929-023-00984-6. PMID: 38012609; PMCID: PMC10683179. 

學生作者：賴姿廷 (共同第一作者)、劉嘉瑋 (共同第一作者)、蔡于宣 (共同第一作者)、林元元

5. Liou CW, Cheng SJ, Yao TH, Lai TT, Tsai YH, Chien CW, Kuo YL, Chou SH, Hsu CC, Wu WL*. Microbial metabolites regulate social novelty via CaMKII neurons in the BNST. Brain Behav Immun. 2023 Oct;113:104-123. doi: 10.1016/j.bbi.2023.06.029. Epub 2023 Jun 29. PMID: 37393058. 

學生作者：劉嘉瑋 (第一作者)、姚子宣、賴姿廷、蔡于宣

6. Liou CW*, Yao TH, Wu WL*. Intracerebroventricular delivery of gut-derived microbial metabolites in mice. J Vis Exp. 2022 Jun 2;(184). doi: 10.3791/63972. PMID: 35723471.

學生作者：劉嘉瑋 (共同第一作者、共同通訊作者)、姚子宣 (共同第一作者)

7. Wu JT, Sun CL, Lai TT, Liou CW, Lin YY, Xue JY, Wang HW, Chai LMX, Lee YJ, Chen SL, Chang AYW, Hung JH, Hsu CC, Wu WL*. Oral short-chain fatty acids administration regulates innate anxiety in adult microbiome-depleted mice. Neuropharmacology. 2022 Aug 15;214:109140. doi: 10.1016/j.neuropharm.2022.109140. Epub 2022 May 22. PMID: 35613660.

學生作者：武若婷 (共同第一作者)、賴姿廷 (共同第一作者)、劉嘉瑋 、林元元、薛家滎

8. Needham BD*, Funabashi M, Adame MD, Wang Z, Boktor JC, Haney J, Wu WL, Rabut C, Ladinsky MS, Hwang SJ, Guo Y, Zhu Q, Griffiths JA, Knight R, Bjorkman PJ, Shapiro MG, Geschwind DH, Holschneider DP, Fischbach MA, Mazmanian SK*.  A gut-derived metabolite alters brain activity and anxiety behavior in mice. Nature. 2022 Feb;602(7898):647-653. doi: 10.1038/s41586-022-04396-8. Epub 2022 Feb 14. PMID: 35165440; PMCID: PMC9170029.

9. Wu WL*, Adame MD, Liou CW, Barlow JT, Lai TT, Sharon G, Schretter CE, Needham BD, Wang MI, Tang W, Ousey J, Lin YY, Yao TH, Abdel-Haq R, Beadle K, Gradinaru V, Ismagilov RF, Mazmanian SK. Microbiota regulate social behavior via stress response neurons in the brain. Nature. 2021 Jul;595(7867):409-414. doi: 10.1038/s41586-021-03669-y. Epub 2021 Jun 30. PMID: 34194038; PMCID: PMC8346519.

學生作者：劉嘉瑋、賴姿廷、林元元、姚子宣

10. Wu WL*, Cheng SJ, Lin SH, Chuang YC, Huang EY, Chen CC*. The Effect of ASIC3 Knockout on Corticostriatal Circuit and Mouse Self-grooming Behavior. Front Cell Neurosci. 2019 Mar 12;13:86. doi: 10.3389/fncel.2019.00086. PMID: 30930747; PMCID: PMC6424217.

11. Lee YK*, Mehrabian P, Boyajian S, Wu WL, Selicha J, Vonderfecht S, Mazmanian SK*. The Protective Role of Bacteroides fragilis in a Murine Model of Colitis-Associated Colorectal Cancer. mSphere. 2018 Nov 14;3(6):e00587-18. doi: 10.1128/mSphere.00587-18. PMID: 30429227; PMCID: PMC6236802.

12. Ko J, Isas JM, Sabbaugh A, Yoo JH, Pandey NK, Chongtham A, Ladinsky M, Wu WL, Rohweder H, Weiss A, Macdonald D, Munoz-Sanjuan I, Langen R, Patterson PH, Khoshnan A*. Identification of distinct conformations associated with monomers and fibril assemblies of mutant huntingtin. Hum Mol Genet. 2018 Jul 1;27(13):2330-2343. doi: 10.1093/hmg/ddy141. PMID: 29912367; PMCID: PMC6005051.

13. Needham BD, Tang W, Wu WL*. Searching for the gut microbial contributing factors to social behavior in rodent models of autism spectrum disorder. Dev Neurobiol. 2018 May;78(5):474-499. doi: 10.1002/dneu.22581. Epub 2018 Feb 20. PMID: 29411548.

14. Wu WL*. Association among gut microbes, intestinal physiology, and autism. EBioMedicine. 2017 Nov;25:11-12. doi: 10.1016/j.ebiom.2017.10.013. Epub 2017 Oct 13. PMID: 29046233; PMCID: PMC5704070.

15. Chan KY, Jang MJ, Yoo BB, Greenbaum A, Ravi N, Wu WL, Sánchez-Guardado L, Lois C, Mazmanian SK, Deverman BE*, Gradinaru V*. Engineered adeno-associated viruses for efficient and noninvasive gene delivery throughout the central and peripheral nervous systems. Nat Neurosci. 2017 Aug;20(8):1172-1179. doi: 10.1038/nn.4593. Epub 2017 Jun 26. PMID: 28671695; PMCID: PMC5529245.

16. Wu WL*, Hsiao EY, Yan Z, Mazmanian SK, Patterson PH. The placental interleukin-6 signaling controls fetal brain development and behavior. Brain Behav Immun. 2017 May;62:11-23. doi: 10.1016/j.bbi.2016.11.007. Epub 2016 Nov 9. PMID: 27838335; PMCID: PMC5373986. (Highlighted in: Brain, Behavior, and Immunity. 62: 9-10.)

17. Chu H*, Khosravi A, Kusumawardhani IP, Kwon AH, Vasconcelos AC, Cunha LD, Mayer AE, Shen Y, Wu WL, Kambal A, Targan SR, Xavier RJ, Ernst PB, Green DR, McGovern DP, Virgin HW, Mazmanian SK*. Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease. Science. 2016 May 27;352(6289):1116-20. doi: 10.1126/science.aad9948. Epub 2016 May 5. PMID: 27230380; PMCID: PMC4996125.

18. Chow KH, Yan Z, Wu WL*. Induction of maternal immune activation in mice at mid-gestation stage with viral mimic poly(I:C). J Vis Exp. 2016 Mar 25;(109):e53643. doi: 10.3791/53643. PMID: 27078638; PMCID: PMC4841312.

19. Deverman BE*, Pravdo PL, Simpson BP, Kumar SR, Chan KY, Banerjee A, Wu WL, Yang B, Huber N, Pasca SP, Gradinaru V*. Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain. Nat Biotechnol. 2016 Feb;34(2):204-9. doi: 10.1038/nbt.3440. Epub 2016 Feb 1. PMID: 26829320; PMCID: PMC5088052.

20. Wu WL*, Adams CE, Stevens KE, Chow KH, Freedman R, Patterson PH. The interaction between maternal immune activation and alpha 7 nicotinic acetylcholine receptor in regulating behaviors in the offspring. Brain Behav Immun. 2015 May;46:192-202. doi: 10.1016/j.bbi.2015.02.005. Epub 2015 Feb 12. PMID: 25683697; PMCID: PMC4414803.

21. Wu WL, Cheng CF, Sun WH, Wong CW, Chen CC*. Targeting ASIC3 for pain, anxiety, and insulin resistance. Pharmacol Ther. 2012 May;134(2):127-38. doi: 10.1016/j.pharmthera.2011.12.009. Epub 2011 Dec 30. PMID: 22233754.

22. Wu WL, Lin YW, Min MY, Chen CC*. Mice lacking Asic3 show reduced anxiety-like behavior on the elevated plus maze and reduced aggression. Genes Brain Behav. 2010 Aug;9(6):603-14. doi: 10.1111/j.1601-183X.2010.00591.x. Epub 2010 May 20. PMID: 20497234.

23. Wu WL, Wang CH, Huang EY, Chen CC*. Asic3(-/-) female mice with hearing deficit affects social development of pups. PLoS One. 2009 Aug 4;4(8):e6508. doi: 10.1371/journal.pone.0006508. PMID: 19652708; PMCID: PMC2714966.

24. Lin YW, Min MY, Lin CC, Chen WN, Wu WL, Yu HM, Chen CC*. Identification and characterization of a subset of mouse sensory neurons that express acid-sensing ion channel 3. Neuroscience. 2008 Jan 24;151(2):544-57. doi: 10.1016/j.neuroscience.2007.10.020. Epub 2007 Nov 1. PMID: 18082972.

25. Liu RT, Chen YJ, Chou FF, Li CL, Wu WL, Tsai PC, Huang CC, Cheng JT*. No correlation between BRAFV600E mutation and clinicopathological features of papillary thyroid carcinomas in Taiwan. Clin Endocrinol (Oxf). 2005 Oct;63(4):461-6. doi: 10.1111/j.1365-2265.2005.02367.x. PMID: 16181240.

BOOK

• Malkova N, Wu WL (Co-first author), Hsiao EY*, 2015. Modeling the Maternal Immune Activation Risk Factor for Schizophrenia. Modeling the Psychopathological Dimensions of Schizophrenia, eds Pletnikov, M., Waddington, J. (Elsevier).

CONFERENCE PAPERS

• Deverman BE*, Pravdo PL, Simpson BP, Kumar SR, Luo Y, Chan KY,Banerjee A, Wu WL, Yang B, Huber N, Pasca SP, Gradinaru V* (2016) Using Cre-Dependent In Vivo Selection to Identify AAV Variants That Enable Efficient and Widespread Gene Transfer to the Adult Central Nervous System. Molecular Therapy, 24 (S1). S99. ISSN 1525-0016. 

•  Wu WL*, Hsiao EY, Yan Z, Mazmanian SK, Patterson PH. (2015) Maternal Immune Activation Perturbs Fetal Brain Development and Adult Behaviors Through Placental Trophoblast IL-6 Activation. Schizophrenia Bulletin, 41 (S1). Art. No. S216. ISSN 0586-7614. 

•  Wu WL*, Adams CE, Stevens KE, Freedman R, Patterson PH. (2015) Nicotinic Cholinergic Modulation of the Fetal Brain Response to Maternal Immune Activation. Schizophrenia Bulletin, 41 (S1). S216. ISSN 0586-7614. 

PATENTS

1. Mazmanian SK, Wu WL, Adame MD, Needham BH. 2021 Probiotic therapies for social deficit and stress response.
   US Patent App. 17/652,464 

2. Hsiao EY, Wu, WL, Mazmanian SK, Patterson PH. 2015. Composition and Methods Comprising Bacteria for Improving Behavior in Neurodevelopmental Disorders. US Patent App. 14/925,240