Bioinorganic Research
Professor Orde Munro
Professor Orde Munro
On this site we aim to provide readers with an overview of the Bioinorganic Chemistry Research Group at WITS University in Johannesburg and additional information about our work and facilities.
A new metallodrug candidate crystallizing in an NMR tube after spectroscopy.
To rationally design and study new metal complexes with potential applications in chemistry, biology, and medicine.
We are especially interested in understanding the fundamental chemistry of newly designed compounds to develop them into metallodrug candidates for chemotherapy with narrow cellular targets (e.g., human topoisomerase I), luminescent probes for cell and organelle imaging, metal chelates for protein capture (e.g., IMAC), metal chelates for artificial metalloenzymes, and applications in molecular electronics (e.g., coordination polymers with low band gaps).
Science is tough - but amazing - and we love chemistry and biochemistry! This makes doing challenging fundamental work possible because understanding how things work at the molecular level, especially at the interface of chemistry and biology, can be very tricky with novel metal chelates. Above all, we hope to do science that is both fundamental and useful to humanity, e.g., develop metallodrug candidates (preclinical) that may one day thwart drug-resistant bacterial infections or kill drug-resistant tumors.
The Tyndall effect with a drug-bound protein in solution.
Bioinorganic chemistry has a rich history dating back to the 1970s at WITS University with research and scholarly contributions from John Pratt, David Baldwin, Timothy Egan (who, despite chemotherapy, lost his battle with a rare kidney cancer in the first week of May 2022), and Helder Marques (to name a few) over many decades. Numerous students have passed through the group over the years and have excelled under the mentorship from these luminaries.
Going back in living memory, Professor Helder Marques did his PhD under the mentorship of Professor John Pratt in the 1980s before going on sabbatical (Mississippi State University, USA) in the early 1990s and returning as the discipline leader. The current SARChI Chair of Bioinorganic Chemistry studied with Professor Helder Marques as a PhD student (1990-1995) before spending time as a postdoctoral research fellow in Professor W. Robert Scheidt's group at the University of Notre Dame (USA) and then returning to the RSA to start an independent academic career in Inorganic Chemistry at the University of Natal (1997).
Things have now come full circle with Helder the Emeritus Professor of Bioinorganic Chemistry and Professor Munro the current leader of the discipline at WITS since 2015.