Our lab focuses on understanding how the immune system responds to inflammation and microbial signals in the gut, joints, and tumor microenvironments. We integrate molecular immunology, microbiology, and animal models to study the pathogenesis of inflammatory bowel disease (IBD), autoimmune disorders, and infection-related inflammation.

Our main research areas include:

• The plasticity of regulatory T cells (Tregs) and their role in linking gut inflammation
  
  

• The impact of the gut microbiota on immune regulation and chronic inflammation, including its contribution to colorectal cancer
  
  

• Mechanistic studies on how pathogens like Helicobacter pylori manipulate host immune responses to promote persistence
  
  
  

We have established physiologically relevant mouse models of infection and inflammation, enabling us to analyze immune cell responses in vivo. By exploring host–microbe interactions at the cellular and molecular levels, our goal is to uncover therapeutic targets and contribute to the development of new treatments for chronic inflammatory diseases.