Sho Sendo, Allison J. Vela, Myungja Ro, Deepan Thiruppathy, Elizabeth L. Wilkinson, Zixuan Zhao, Wan-Chen Hsieh, Shen Yang, Roxana Coras, Anne-Sophie Bergot, Monica Guma, Anders Nguyen, David A. McBride, Suzanne Devkota, Ranjeny Thomas g, Nisarg J. Shah e, Mattias N.D. Svensson, Karsten Zengler, Stephanie M. Stanford, Nunzio Bottini (2025). Interaction between haploinsufficiency of PTPN2 and patient microbiome promotes autoimmune arthritis in mice. Journal of Autoimmunnity. Volume 156, 103452. DOI: 10.1016/j.jaut.2025.103452 

Wan-Chen Hsieh, Tzu-Sheng Hsu, Kuan-Wen Wu, Ming-Zong Lai (2025).Therapeutic application of regulatory T cell in osteoarthritis. Journal of Microbiology, Immunology and Infection. DOI: 10.1016/j.jmii.2025.04.003

Meng-Jen Wu, Shan-Min Yang, Wei-Kai Fang, Tsan-Jan Chen, Chun-Yi Wu, Yen-Jung Hsu, Cheng-En Shen, Yu-Chia Cheng, Wan-Chen Hsieh, Chiou-Hwa Yuh, Muh-Hwa Yang, Hsing-Jien Kung & Wen-Ching Wang （2025). KDM4C works in concert with GATA1 to regulate heme metabolism in head and neck squamous cell carcinoma. Cellular and Molecular Life Science. 82, 170. DOI: 10.1007/s00018-025-05693-x

Chao-Ting Ho, Ying-Chi Kao, Yueh-Ming Shyu, I-Ching Wang＊, Qiao-Xuan Liu＊, Shao-Wen Liu, Shih-Chen Huang, Han Chiu, Li-Wen Hsu, Tzu-Sheng Hsu, Wan-Chen Hsieh, Chieh-Cheng Huang (2025). Assembly of MSCs into a Spheroid Configuration Increases Poly(I:C)-mediated TLR3 Activation and the Immunomodulatory Potential of MSCs for Alleviating Murine Colitis. Stem Cell Research & Therapy, 16, 172. DOI:10.1186/s13287-025-04297-3

W. -Y. Sit, M.-L. Cheng, T.-J. Chen, C.-J. Chen, B.-N..Chen,.D.-J. Huang, P.-L. Chen, Y.-C. Chen, C.-J. Lo, D.-C.Wu, W.-C. Hsieh, C.-T. Chang, R.-H. Chen & W.-C.Wang. (2024) Helicobacter pylori PldA modulates TNFR1-mediated p38 signaling pathways to regulate macrophage responses for its survival. Gut Microbes, 16:1, 2409924. DOI: 10.1080/19490976.2024.2409924

H.-Y. Chen, W.-C. Hsieh,Y.-C Liu, H.-Y Li, P.-Y. Liu, Y.-T. Hsu, S.-C. Hsu, A.-C.Luo, W.-C. Kuo,Y.-J. Huang, G.-G. Liou, M.-Y. Lin, C.-J. Ko ,H.-C. Tsai and S.-J. Chang. (2024) Mitochondrial injury induced by a Salmonella genotoxin triggers the proinflammatory senescence-associated secretory phenotype. Nature Communications 15 (2778). DOI:10.1038/s41467-024-47190-y

W.-C. Hsieh , M. Svensson , M. Zoccheddu, M. Tremblay, S. Sakaguchi, S. Stanford and N. Bottini. (2020). PTPN2 links colonic and joint inflammation in experimental autoimmune arthritis. JCI Insight. 5(20):e141868. DOI: 10.1172/jci.insight.141868

S. Yang, M. Svensson, N. Harder, W.-C. Hsieh, E. Santelli1, W. Kiosses, J. Moresco, J. Yates, C. King, L. Liu, S. Stanford, and N. Bottini. (2020). PTPN22 phosphorylation acts as a molecular rheostat for the inhibition of TCR signaling. Science Signaling 13(623), DOI: 10.1126/scisignal.aaw8130

W.-C. Hsieh, T.-S. Hsu, Y.-J. Chang, & M.-Z Lai. (2018) IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells. Nature Communications 9(463). DOI: 10.1038/s41467-018-02862-4

T.-F. Chou, Y.-T. Chuang, W.-C. Hsieh, P.-Y. Chang, H.-Y. Liu, S.-T. Mo, T.-S. Hsu, S.-C. Miaw, R.-H. Chen, Adi Kimchi & M.-Z. Lai. (2016). Tumor suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression. Nature Communications 7(11904). DOI:10.1038/ncomms11904

H.-W.Hsiao, T.-S. Hsu, W.-H. Liu, W.-C. Hsieh, T.-F. Chou, Y.-J. Wu, S.-T. Jiang and M.-Z. Lai. (2015). Deltex1 antagonizes HIF-1a and sustains the stability of regulatory T cells in vivo. Nature Communications 6(6353). DOI: 10.1038/ncomms7353

C.-L. Hung, H.-H. Cheng, W.-C. Hsieh, ZT.-Y. Tsai, H.-K. Tsai, C.-H. Chu, W.-P. Hsieh, C.-H. Lai, and W.-C. Wang. (2015). The CrdRS two-component system responds to nitrosative stress in Helicobacter pylori. Molecular Microbiology 97 (6). DOI: 10.1111/mmi.13089

 W.-C. Hsieh, Y.-T. Chuang, I.-H. Chiang, S.-C. Hsu, S.-C. Miaw, and M.-Z. Lai. (2014). Inability to resolve specific infection generates innate immunodeficiency syndrome in Xiap-/- mice. Blood 124(18). DOI: blood-2014-03-564609 Highlighted by a commentary in the same issue of Blood

C.-H. Lai, H.-J. Wang, Y.-C. Chang, W.-C. Hsieh, H.-J. Lin, C.-H. Tang, J.-C. Sheu, C.-J. Lin, M.-S. Yang, S.-F. Tseng, W.-C. Wang. (2011). Helicobacter pylori CagA-mediated IL-8 induction in gastric epithelial cells is cholesterol-dependent and requires the C-terminal tyrosine phosphorylation-containing domain. FEMS Microbiology Letters 323 (2). DOI: 10.1111/j.1574-6968.2011.02372.x