In the beginning (1573), a dedicated and eccentric Monk/Scholar Johann Weir performed a demonic ritual that would curse him and all his descendants after him. Did he care about that, though? No. What this ritual would provide would give him unlimited access to the knowledge he needed to write his De Praestiguis Daemonum--good for him he got to write a book. He learned of the ritual from his "research partner" Aamon, a demon, who longed to make things right with God and gain reentrance into heaven. He figured helping a religious monk complete his research might just be enough. He was very wrong. After the ritual was completed, Aamon realized that he had been tricked by the demon who gave him the ritual and was now bound to the cursed family forever.
Fast forward to 2015. Regina Weir is heading to therapy. After the deaths of three grandparents and her father, all within a short time span, she has not been doing the greatest. She has even started seeing things from the corner of her eye that should not be there (like gigantic meatball spider demons). She was sent to Maple Woods Behavioral Center after her doctor suggested the center during her last hospital stay after the death of her father. Nervous, but longing to become who she used to be, she joins the group therapy session. Unbeknownst to her, this whole center is a set up by her uncle as a way to "break the bad news" and transition her to her new life working as a demon hunter in the secret international government agency of W.E.I.R.D., The Worldwide Extranormal Intervention and Reconnaissance Department. Of which he is the director, as his father--Regina's grandfather--was before him. After grief binge-watching the entire Marvel Cinematic Universe....especially Captain America...he decided this was the best way to do it. He was wrong.
During therapy, Regina tells the group--other undercover agents posing as fellow patients--her entire story through in-depth cinematic flashbacks. She explains how two grandparents on different sides of the family died hours apart for unrelated reasons; how her grandfather--the former W.E.I.R.D. director--died of Alzheimers; how she could not get a job with her degree no matter how many applications she submitted; how she was helping her dad pack up his parent's house when she touched a book, had a seizure, and then all of a sudden began seeing meatball spiders everywhere; and finally how during one of her 'episodes' her father died and that she worries it is all her fault.
The agents feel an inner cringe and guilt so massive about this plan that they give up the charade and make her uncle tell Regina the truth, all of it. Regina does not know what to do after she is given many truth bombs to process. she just wants to go home and cry. So that is what she does. But when she gets home, she sees that her grandmother is there fighting with her mom--a normal occurrence--but with a demon latched on her neck. Regina then summons her new, very not controlled abilities, and defeats the demon, saving everyone but destroying her mom's living room.
Volume One Ends with Regina packing up and going to basic training in Las Vegas at the Mirage Hotel--which is actually one of the many WEIRD facilities that exist in the world--along with her new soul-bound bodyguard, Aamon. She is introduced to all the other trainees of the W.E.I.R.D.O.S. program: a brother and sister where one can become a minotaur the other a sand-controlling serpent girl; the son of Mothman who himself is a Mothman; A chupacabra sent by his family as a punishment for his last mess-up; A dirt devil from Arizona; the vampire princess of New Orleans who is not happy to be there; a fireworks heiress who happens to be the leading expert on explosives and firearms in the world; a woman who possesses the spirit of the Cigwe--Mythical Potawatomi Thunderbird; and an actual witch from Salem. She goes to bed anticipating what training is going to be like and thinking of what her life will be, while Aamon stays up haunted that Regina looks exactly like his long-dead former love.