Most cells co-express numerous GPCRs that differ both in their localization within cells at steady state and their trafficking after activation. A main interest of our lab is to elucidate mechanisms mediating precise molecular sorting of GPCRs and proteins with which they functionally interact. 

GPCR trafficking flexibly controls cellular responses to ligands and we now know that GPCR signaling, conversely, controls specific trafficking events. Our group is working to delineate the fundamental basis of this bidirectional control system and determine its physiological functions.

GPCRs can be activated by ligands at multiple membrane locations, with the location of activation profoundly shaping downstream effects. We are exploring how location encodes selectivity in downstream GPCR signaling, focusing on signal initiation from endosomes and from the primary cilium.

The GPCR signaling-trafficking interface has taught us new  principles for control of cell physiology by endogenous ligands, and has revealed new aspects of specificity in drug action. A major interest of our group is to further explore this frontier through the study of native cell and tissue preparations, and to leverage it for developing better drugs.