Fisher NM, von Zastrow M. Opioid receptors reveal a discrete cellular mechanism of endosomal G protein activation.
PNAS. 2025 April 22.
Blythe EE, Fagan RR, von Zastrow M. Endocytosis sculpts distinct cAMP signal transduction by endogenously coexpressed GPCRs.
Preprint. 2025 Feb 25.
Li J, Inoue A, Manglik A, von Zastrow M. Role of the G protein-coupled receptor kinase 2/3 N terminus in discriminating the endocytic effects of opioid agonist drugs.
Mol Pharmacol. 2025 Jan.
Ripoll L, Li Y, Dessauer CW, von Zastrow M. Spatial organization of adenylyl cyclase and its impact on dopamine signaling in neurons.
Nat Commun. 2024 Sep 27.
Fagan RR, Lee DF, Geron M, Scherrer G, von Zastrow M, Ehrlich AT. Selective targeting of mu opioid receptors to primary cilia.
Cell Rep. 2024 May 28.
Blythe EE, von Zastrow M. β-Arrestin-independent endosomal cAMP signaling by a polypeptide hormone GPCR.
Nat Chem Biol. 2023 Sep 25.
Jullié D, Benitez C, Knight TA, Simic MS, von Zastrow M. Endocytic trafficking determines cellular tolerance of presynaptic opioid signaling.
Elife. 2022 Nov 15.
Barsi-Rhyne B, Manglik A, von Zastrow M. Discrete GPCR-triggered endocytic modes enable β-arrestins to flexibly regulate cell signaling.
Elife. 2022 Oct 17.
Peng GE, von Zastrow M. A Live-Cell Imaging Assay for Nuclear Entry of cAMP-Dependent Protein Kinase Catalytic Subunits Stimulated by Endogenous GPCR Activation.
Methods Mol Biol. 2022.
Tsvetanova NG, Trester-Zedlitz M, Newton BW, Peng GE, Johnson JR, Jimenez-Morales D, Kurland AP, Krogan NJ, von Zastrow M. Endosomal cAMP production broadly impacts the cellular phosphoproteome.
J Biol Chem. 2021.
Peng GE, Pessino V, Huang B, von Zastrow M. Spatial decoding of endosomal cAMP signals by a metastable cytoplasmic PKA network.
Nat Chem Biol. 2021.
Stoeber M, Jullié D, Li J, Chakraborty S, Majumdar S, Lambert NA, Manglik A, von Zastrow M. Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells.
Elife. 2020 Feb 25.
Jullié D, Stoeber M, Sibarita JB, Zieger HL, Bartol TM, Arttamangkul S, Sejnowski TJ, Hosy E, von Zastrow M. A Discrete Presynaptic Vesicle Cycle for Neuromodulator Receptors.
Neuron. 2020 Feb 19.
Lobingier BT, von Zastrow M. When trafficking and signaling mix: How subcellular location shapes G protein-coupled receptor activation of heterotrimeric G proteins.
Traffic. 2019 Feb.
Stoeber M, Jullié D, Lobingier BT, Laeremans T, Steyaert J, Schiller PW, Manglik A, von Zastrow M. A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action.
Neuron. 2018 Jun 6.
Eichel K, Jullié D, Barsi-Rhyne B, Latorraca NR, Masureel M, Sibarita JB, Dror RO, von Zastrow M. Catalytic activation of β-arrestin by GPCRs.
Nature. 2018 May.