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Although extensively revised, the general concepts remain as in previous editions. The aim is still to provide a text for undergraduate veterinary students, a reference work for veterinarians in general practice and laboratory scientists, and a stimulating introduction to the subject for those wishing to specialize in veterinary anaesthesia through the examinations of the Royal College of Veterinary Surgeons, the American College of Veterinary Anesthesiologists and the European College of Veterinary Anaesthesia. Because we believe that clinical anaesthesia encompasses much more than an exercise in applied pharmacology, emphasis is still on the effects of clinically useful doses of drugs and of practical techniques in animal patients, rather than on pharmacological effects demonstrated in healthy experimental animals in laboratories. We wish to express our appreciation of the invaluable help given by Mrs Lorraine Leonard, librarian of the University of Cambridge Veterinary School, and the librarians at the Royal College of Veterinary Surgeons in tracing older references. Mr Stephen Freane of the Royal Veterinary College gave much assistance with computer-generated figures. Finally, our warmest thanks are due to the publishers for their patience, and especially to Deborah Russell whose encouragement ensured completion of the manuscript.