Publications

A microbiota and dietary metabolite integrates DNA repair and cell death to regulate embryo viability and aneuploidy during aging.
Sonowal R, Swimm AI, Cingolani F, Parulekar N, Cleverley TL, Sahoo A, Ranawade A, Chaudhuri D, Mocarski ES, Koehler H, Nitsche K, Mesiano S, Kalman D.
Sci Adv. 2023 Feb 24;9(8):eade8653. doi: 10.1126/sciadv.ade8653. Epub 2023 Feb 24. PMID: 36827370; PMCID: PMC9956122.

Intradermal but not intramuscular modified vaccinia Ankara immunizations protect against intravaginal tier2 simian-human immunodeficiency virus challenges in female macaques.
Bollimpelli VS, Reddy PBJ, Gangadhara S, Charles TP, Burton SL, Tharp GK, Styles TM, Labranche CC, Smith JC, Upadhyay AA, Sahoo A, Legere T, Shiferaw A, Velu V, Yu T, Tomai M, Vasilakos J, Kasturi SP, Shaw GM, Montefiori D, Bosinger SE, Kozlowski PA, Pulendran B, Derdeyn CA, Hunter E, Amara RR.
Nat Commun. 2023 Aug 8;14(1):4789. doi: 10.1038/s41467-023-40430-7. PMID: 37553348; PMCID: PMC10409804.

A clade C HIV-1 vaccine protects against heterologous SHIV infection by modulating IgG glycosylation and T helper response in macaques.
Sahoo A, Jones AT, Cheedarla N, Gangadhara S, Roy V, Styles TM, Shiferaw A, Walter KL, Williams LD, Shen X, Ozorowski G, Lee WH, Burton S, Yi L, Song X, Qin ZS, Derdeyn CA, Ward AB, Clements JD, Varadarajan R, Tomaras GD, Kozlowski PA, Alter G, Amara RR.
Sci Immunol. 2022 Jul 22;7(73):eabl4102. doi: 10.1126/sciimmunol.abl4102. Epub 2022 Jul 22. PMID: 35867800; PMCID: PMC9410801.

Structure-guided changes at the V2 apex of HIV-1 clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies.
Sahoo A, Hodge EA, LaBranche CC, Styles TM, Shen X, Cheedarla N, Shiferaw A, Ozorowski G, Lee WH, Ward AB, Tomaras GD, Montefiori DC, Irvine DJ, Lee KK, Amara RR.
Cell Rep. 2022 Mar 1;38(9):110436. doi: 10.1016/j.celrep.2022.110436. PMID: 35235790; PMCID: PMC8982139.

V2 hotspot optimized MVA vaccine expressing stabilized HIV-1 Clade C envelope Gp140 delays acquisition of heterologous Clade C Tier 2 challenges in Mamu-A*01 negative Rhesus Macaques.
Styles TM, Gangadhara S, Reddy PBJ, Sahoo A, Shiferaw A, Welbourn S, Kozlowski PA, Derdeyn CA, Velu V, Amara RR.
Front Immunol. 2022 Jul 22;13:914969. doi: 10.3389/fimmu.2022.914969. PMID: 35935987; PMCID: PMC9353326.

SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung.
Routhu NK, Cheedarla N, Bollimpelli VS, Gangadhara S, Edara VV, Lai L, Sahoo A, Shiferaw A, Styles TM, Floyd K, Fischinger S, Atyeo C, Shin SA, Gumber S, Kirejczyk S, Dinnon KH 3rd, Shi PY, Menachery VD, Tomai M, Fox CB, Alter G, Vanderford TH, Gralinski L, Suthar MS, Amara RR.
Nat Commun. 2021 Jun 11;12(1):3587. doi: 10.1038/s41467-021-23942-y. PMID: 34117252; PMCID: PMC8196016.

A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs..
Routhu NK, Cheedarla N, Gangadhara S, Bollimpelli VS, Boddapati AK, Shiferaw A, Rahman SA, Sahoo A, Edara VV, Lai L, Floyd K, Wang S, Fischinger S, Atyeo C, Shin SA, Gumber S, Kirejczyk S, Cohen J, Jean SM, Wood JS, Connor-Stroud F, Stammen RL, Upadhyay AA, Pellegrini K, Montefiori D, Shi PY, Menachery VD, Alter G, Vanderford TH, Bosinger SE, Suthar MS, Amara RR.
Immunity 2021 Mar 9;54(3):542-556.e9. doi: 10.1016/j.immuni.2021.02.001. Epub 2021 Feb 4. PMID: 33631118; PMCID: PMC7859620.

Protein model discrimination attempts using mutational sensitivity, predicted secondary structure, and model quality information.
Khare S, Bhasin M, Sahoo A, Varadarajan R.
Proteins. 2019 Apr;87(4):326-336. doi: 10.1002/prot.25654. Epub 2019 Jan 15. PMID: 30615225.

Indoles from commensal bacteria extend healthspan.
Sonowal R, Swimm A, Sahoo A, Luo L, Matsunaga Y, Wu Z, Bhingarde JA, Ejzak EA, Ranawade A, Qadota H, Powell DN, Capaldo CT, Flacker JM, Jones RM, Benian GM, Kalman D.
Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7506-E7515. doi: 10.1073/pnas.1706464114. Epub 2017 Aug 21. PMID: 28827345; PMCID: PMC5594673.

Residue proximity information and protein model discrimination using saturation-suppressor mutagenesis.
Sahoo A, Khare S, Devanarayanan S, Jain PC, Varadarajan R.
Elife. 2015 Dec 30;4:e09532. doi: 10.7554/eLife.09532. PMID: 26716404; PMCID: PMC4758949.

Protein model discrimination using mutational sensitivity derived from deep sequencing.
Adkar BV, Tripathi A, Sahoo A, Bajaj K, Goswami D, Chakrabarti P, Swarnkar MK, Gokhale RS, Varadarajan R.
Structure. 2012 Feb 8;20(2):371-81. doi: 10.1016/j.str.2011.11.021. PMID: 22325784.

Lab-301,Mehta Family Centre for Engineering in Medicine, Department of Biological Sciences and Bioengineering (BSBE), Indian Institute of Technology Kanpur, Kanpur, UP 208016, India