The local cohomology of a regular ring is known in many cases to exhibit remarkable finiteness properties. If R is a polynomial ring over a field of characteristic 0, the local cohomology of R is finitely generated (in fact, holonomic) over the ring of differential operators. In characteristic p > 0, the local cohomology of R is finitely generated (in fact, unit) over the ring R<F>, defined by the relation r^pF = Fr for r in R. Much of this structure is unavailable if R has singularities, but in some circumstances, enough useful structure remains to enable the proof of powerful finiteness results. In this talk, we will review the prime characteristic setting, with a focus on the sets of associated and minimal primes of local cohomology, and will present joint work with Eric Canton on the case of complete intersection rings.