GLIMPSE

Background

GLP-1 receptor agonists are topical due to concerns of increased risk of pulmonary aspiration secondary to delayed gastric emptying. These anti-hyperglycaemic drugs are increasingly being used for the management of both diabetes and obesity, as well as more novel indications. Patients access these medications from online websites, so the proportion of the surgical population established on them is unknown. There could be substantial benefits to clinical practice by improving understanding of the impact of GLP1-RAs on peri-operative care, as highlighted by recent national guidelines.

Project Design

GLIMPSE is a national, observational, snapshot-style project including all patients established on GLP-1RAs who require anaesthetic care for a procedure (elective or emergency). It will take place in October-November 2025, with the exact 16-day period at the discretion of the participating centre.

Getting Involved

Each site will require a consultant and resident doctor lead, who will need to register with the project with their local audit department, as well as local investigators to assist with data collection. A pilot at the sponsor institution demonstrated that the data were easily collected by a small team of residents. Data will be collected onto a piloted proforma and uploaded to a REDCap database.

All participants will be listed as collaborators on the primary publications that arise from GLIMPSE.

If you would like to take part in GLIMPSE as a collaborator, please complete this short form to register and we will be in touch with next steps.

If you have any questions about the study, please email plan@uk-plan.net.

Investigators

• Resident Doctor Lead - Dr Frances Beatty

• Project Lead - Dr Thomas Potter

• Chief Investigator - Dr Kariem El-Boghdadly