GLIMPSE

Background

GLIMPSE is a multicentre service evaluation planned to run over a 16-day period. It aims to identify: 

1. The proportion of patients established on GLP-1 RAs presenting for surgery

2. How patients established on GLP-1RAs are managed peri-operatively

3. Peri-operative outcomes of patients on GLP-1RAs compared with those not on GLP-1 RAs

GLP-1 receptor agonists are topical due to concerns of increased risk of pulmonary aspiration secondary to delayed gastric emptying. These antihyperglycaemic drugs are  used increasingly for management of both diabetes and obesity as well as more novel indications. Patients can access these medications from online websites, so the proportion of the surgical population established on these medications is currently unknown.  There could be substantial benefits to clinical practice by improving our understanding of the impact of GLP1-RAs in peri-operative care, as highlighted by the recent national guidelines published in January 2025.

We therefore designed an observational, snapshot-style project including all patients established on GLP-1RAs who require anaesthetic care for a procedure (elective or emergency). There is no long-term follow-up of patients. There is no increased risk to patient care or change in clinical practice resulting from participation in this project. The service evaluation has been registered at the sponsor institution and has been approved by the Caldicott Guardian. The service evaluation will require registration with audit departments at all participating sites. Each site will need a named trainee and consultant or SAS lead, and have secured audit department approval prior to data collection.

We conducted an initial pilot at the sponsor institution, which demonstrated that the data were easily collected by a small team of trainees. Data will be collected onto paper CRF and then uploaded onto a REDCap database.

Contacts

Please do not hesitate to contact the GLIMPSE team via email on glimpse.study1@gmail.com

Or should you require further information:

• The project lead: Dr Thomas Potter, thomasedward.potter@nhs.net

• The Chief investigator: Dr Kariem El-Boghdadly, kariem.El-Boghdadly@nhs.net

 Many thanks for your consideration and we hope you will join us in this exciting project!

 Kind regards,

 Tom Potter, Frances Beatty, Sophie Bloomfield, Mayur Murali, John Cronin, Danny Wong, Justin Kua, Andrew McKechnie, Kariem El-Boghdadly