Publications

Rued BE, Federle MJ. 2023. The ComRS-SigX pathway regulates natural transformation in Streptococcus ferus. JBac.

Resko ZJ, Anderson CM, Federle MJ, Alonzo F. 2023. A staphylococcal glucosaminidase drives inflammatory responses by processing peptidoglycan chains to physiological lengths. Infectious Immunology

Rued BE, Anderson CM, Federle MJ. 2022. The proteomic and transcriptomic landscapes altered by Rgg2/3 activity in Streptococcus pyogenes. JBac

Chang JC, Wiliening RV, Rahbari KM, Federle MJ. 2022. Quorum sensing regulation of a major facilitator superfamily transporter affected multiple streptococcal virulence factors. JBac

Laczkovich I, et al. 2022. Discovery of unannotated small open reading frames in Streptococcus pneumoniae D39 involved in quorum sensing and virulence using ribosome profiling. mBio

Woo JKK, McIver KS, Federle MJ. 2022. Carbon catabolite repression on the Rgg2.3 quorum sensing systeim in Streptococcus pyogenes is mediated by PTSman and Mga. Molecular Microbiology    

Rahbari KM, Chang JC, Federle MJ. 2021. A Streptococcus quorum sensing system enables suppression of innate immunity. mBio

Rued BE, Covington BC, Bushin LB, Szewczyk G, Laczkovich I, Seyedsayamdost MR, Federle MJ. 2021. Quorum sensing in Streptococcus mutans regulates production of Tryglysin, a novel RaS-RiPP antimicrobial compound. mBio. In Press. 

Capodagli GC, Tylor KM, Kaelber JT, Petrou VI, Federle MJ, Neiditch MB. 2020. Structure-function studies of Rgg binding to pheromones and target promoters reveal a model of transcription factor interplay. Proc. Natl. Acad. Sci. USA. 117(39):24494-24502. 

Bushin LB, Covington BC, Rued BE, Federle MJ, Seyedsayamdost MR. 2020. Discovery and biosynthesis of Streptosactin, a sactipeptide with an alternative topology encoded by commensal bacteria in the human microbiome. J. Am. Chem. Soc. 142(38):16265-16275. 

Gogos A, Federle MJ. 2019. Modeling Streptococcus pyogenes Pharyngeal Colonization in the Mouse. Front. Cell. Infect. Microbiol. 9: 137. 

Mashburn-Warren L, Goodman SD, Federle MJ, Prehna G. 2018. The conserved mosaic prophage protein paratox inhibits the natural competence regulator ComR in Streptococcus. Sci Rep. 8(1):16535. 

Gogos A, Jimenez JC, Chang JC, Wilkening RV, Federle MJ. 2018. A quorum sensing-regulated protein binds cell-wall components and enhances lysozyme resistance in Streptococcus pyogenes. J. Bacteriol.

Cook LC, Hu H, Maienschein-Cline M, Federle MJ. 2018. A Vaginal Tract Signal Detected by the Group B Streptococcus SaeRS System Elicits Transcriptomic Changes and Enhances Murine Colonization. Infect. Immun. 86.

Perez Morales TG, Ratia K, Wang D-S, Gogos A, Driver TG, Federle MJ. 2018. A novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO. J Biol Chem.

Wilkening R V, Federle MJ. 2017. Evolutionary Constraints Shaping Streptococcus pyogenes-Host Interactions. Trends Microbiol.

Wilkening R V, Capodagli GC, Khataokar A, Tylor KM, Neiditch MB, Federle MJ. 2017. Activating mutations in quorum-sensing regulator Rgg2 and its conformational flexibility in the absence of an intermolecular disulfide bond. J Biol Chem 292:20544–20557.

Shanker E, Federle MJ. 2017. Quorum Sensing Regulation of Competence and Bacteriocins in Streptococcus pneumoniae and mutans. Genes (Basel) 8.

Neiditch MB, Capodagli GC, Prehna G, Federle MJ. 2017. Genetic and Structural Analyses of RRNPP Intercellular Peptide Signaling of Gram-Positive Bacteria. Annu Rev Genet 51:311–333.

Wilkening RV, Chang JC, Federle MJ. 2016. PepO, a CovRS-controlled endopeptidase, disrupts Streptococcus pyogenes quorum sensing. Mol Microbiol 99:71–87.

Talagas A, Fontaine L, Ledesma-Garcia L, Mignolet J, Li de la Sierra-Gallay I, Lazar N, Aumont-Nicaise M, Federle MJ, Prehna G, Hols P, Nessler S. 2016. Structural Insights into Streptococcal Competence Regulation by the Cell-to-Cell  Communication System ComRS. PLoS Pathog 12:e1005980.

Shanker E, Morrison DA, Talagas A, Nessler S, Federle MJ, Prehna G. 2016. Pheromone Recognition and Selectivity by ComR Proteins among Streptococcus Species. PLOS Pathog 12.

Chang JC, Federle MJ. 2016. PptAB Exports Rgg Quorum-Sensing Peptides in Streptococcus. PLoS One 11:e0168461.

Parashar V, Aggarwal C, Federle MJ, Neiditch MB. 2015. Rgg protein structure-function and inhibition by cyclic peptide compounds. Proc Natl Acad Sci U S A 112:5177–5182.

Chang JC, Jimenez JC, Federle MJ. 2015. Induction of a quorum sensing pathway by environmental signals enhances group A streptococcal resistance to lysozyme. Mol Microbiol 97:1097–1113.

Aggarwal C, Jimenez JC, Lee H, Chlipala GE, Ratia K, Federle MJ. 2015. Identification of Quorum-Sensing Inhibitors Disrupting Signaling between Rgg and Short Hydrophobic Peptides in Streptococci. MBio 6:15.

Marks LR, Mashburn-Warren L, Federle MJ, Hakansson AP. 2014. Streptococcus pyogenes biofilm growth in vitro and in vivo and its role in colonization, virulence, and genetic exchange. J Infect Dis 210:25–34.

Jimenez JC, Federle MJ. 2014. Quorum sensing in group A Streptococcus. Front Cell Infect Microbiol 4:127.

Cook LC, Federle MJ. 2014. Peptide pheromone signaling in Streptococcus and Enterococcus. FEMS Microbiol Rev 38:473–492.

Aggarwal C, Jimenez JC, Nanavati D, Federle MJ. 2014. Multiple length peptide-pheromone variants produced by Streptococcus pyogenes directly bind Rgg proteins to confer transcriptional regulation. J Biol Chem 289:22427–22436.

LaSarre B, Federle MJ. 2013. Exploiting quorum sensing to confuse bacterial pathogens. Microbiol Mol Biol Rev 77:73–111.

LaSarre B, Federle MJ. 2013. EMSA Analysis of DNA Binding By Rgg Proteins. Bio-protocol 3.

Lasarre B, Aggarwal C, Federle MJ. 2013. Antagonistic Rgg regulators mediate quorum sensing via competitive DNA binding in Streptococcus pyogenes. MBio 3.

Cook LC, LaSarre B, Federle MJ. 2013. Interspecies communication among commensal and pathogenic streptococci. MBio 4.

Mashburn-Warren L, Morrison DA, Federle MJ. 2012. The cryptic competence pathway in Streptococcus pyogenes is controlled by a peptide pheromone. J Bacteriol 194:4589–4600.

Desai K, Mashburn-Warren L, Federle MJ, Morrison DA. 2012. Development of competence for genetic transformation of Streptococcus mutans in a chemically defined medium. J Bacteriol 194:3774–3780.

LaSarre B, Federle MJ. 2011. Regulation and consequence of serine catabolism in Streptococcus pyogenes. J Bacteriol 193:2002–2012.

Chang JC, LaSarre B, Jimenez JC, Aggarwal C, Federle MJ. 2011. Two group A streptococcal peptide pheromones act through opposing Rgg regulators to control biofilm development. PLoS Pathog 7.

Mashburn-Warren L, Morrison DA, Federle MJ. 2010. A novel double-tryptophan peptide pheromone controls competence in Streptococcus  spp. via an Rgg regulator. Mol Microbiol 78:589–606.