Tumors In Domestic Animals Pdf Download

While many changes are represented in the 4th edition, the format has generally remained the same. The book is, fundamentally, a catalogue of tumors known to occur in domestic animals, organized by body system. Each section within each chapter (except the 1st) is organized into a summary of the current knowledge concerning classification schemes and diagnostic approaches; incidence and prevalence (including age, breed, and sex); sites of tumor development and clinical characteris- tics; gross (macroscopic) and, where appropriate, radi ographic appearance; microscopic appearance (includ- ing histologic, cytologic, or ultrastructural descriptions); behavior (growth and metastasis); and, in many instances, comments concerning etiology or epidemiologic associations, special diagnostic procedures, and, to a much more limited degree, treatment. Importantly, these summaries are almost always well supported by references.

Dr. Meuten's stated goal for the 4th edition was to con dense the formidable and expanding body of information concerning the risks, pathogenesis, diagnosis, classifi cation, and management of tumors in domestic animals into a useful resource for veterinarians, residents, oncol ogists, and diagnostic pathologists. I believe he has succeeded in this goal and I have no doubt that the 4th edition of Tumors in Domestic Animals will find its way into the library of every diagnostic veterinary laboratory and veterinary school in North America. I suspect it would also be a useful complement to the libraries of veterinary oncologists. However, I doubt that the average veterinarian in practice or veterinary student would make frequent reference to this book, and at the current price of almost $300.00 (in the University of Saskatchewan book store), there are probably better values for the nonspecialist. Dr. Meuten also refers to a companion CD-ROM that contains color images to sup plement the black-and-white pictures contained in the book. Regrettably, instructions on how to obtain the CD are not provided, and a representative at the Iowa State Press indicated that no CD was currently available.

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Tumors in Domestic Animals, Fifth Edition is a fully revised new edition of the most comprehensive and authoritative reference on veterinary tumor pathology in common domestic animals, now in full color throughout with the most current advances in research and diagnostics.

Bone is a highly dynamic tissue, and any type of mass effect will result in alteration of the normal architecture. Correctly interpreting such reparative processes and to differentiate them from the primary disease can be challenging. The ability to interpret microscopic findings in conjunction with the various types of diagnostic imaging is often essential to reach an accurate diagnosis. This volume, therefore, integrates characteristic radiographic findings into surgical pathology of tumors of bone, cartilage and other hard tissues. As in previous volumes, dedicated chapters will review the structure and development of the tissues covered in this volume, immunohistochemistry and grading and reporting of specific tumor entities. Special chapters have been committed to the trimming and decalcification of bone and teeth as both steps are essential in providing high quality sections for microscopic interpretation.

A total of 195 tumors were removed from the 96 dogs in this study. In dogs with incidental MGTs, 82 of 88 (93%) tumors were benign and 6 of 88 (7%) were malignant. In dogs with nonincidental MGTs, 75 of 107 (70%) tumors were benign and 32 of 107 (30%) were malignant. Nonincidental MGTs were significantly (OR, 5.83; 95% CI, 2.31 to 14.73; P = .001) more likely to be malignant compared with incidental MGTs. Dogs with nonincidental MGTs were 6.84 times as likely to have a malignant MGT removed compared with dogs with incidental MGTs (OR, 6.84; 95% CI, 2.47 to 18.94; P < .001). The likelihood of malignancy increased by 5% for each 1-kg increase in body weight (OR, 1.05; 95% CI, 1.01 to 1.09; P = .013). Larger tumors were more likely to be malignant than smaller tumors (P = .001).

The goal of this study was to determine whether MGTs found incidentally on examination in a population of dogs presenting for various surgical diseases would differ in malignancy compared with nonincidental MGTs. We hypothesized that there would be no significant difference in the proportion of malignant tumors between those that were incidental and those that were nonincidental. We also evaluated for any criteria that could be used to predict malignancy in canine MGTs.

Medical records of all female dogs that were presented to Garden State Veterinary Specialists and underwent surgery for MGT removal between January 2018 and December 2021 were reviewed. Dogs were included in the nonincidental group if they had surgery primarily for MGT removal. Dogs were included in the incidental group if they had MGTs removed secondarily while under anesthesia for another surgical procedure. Incidental MGTs were removed after surgery was completed to address the primary problem under the same anesthetic event. Data obtained included signalment of each dog (age, breed, reproductive status at the time of surgery for MGT removal), presenting complaint/primary surgical problem for each dog, and histopathologic results of any MGTs removed (including the number of tumors and size and location of each tumor, if available). For the purpose of analysis, tumor size was categorized into 3 groups based on a modified WHO staging system,15 where tumors < 3 cm in diameter were considered T1, tumors 3 to 5 cm were T2, and tumors > 5 cm were T3. Dogs were excluded from the study if biopsy results were not available or if tumor size was not available for at least 1 tumor/dog. In dogs that underwent staged bilateral radical mastectomy, only the demographic data at the time of the first mastectomy were used for statistical analysis. Biopsy results were combined for dogs that underwent staged bilateral radical mastectomy when malignancy rates were evaluated per dog. For dogs in the incidental group, medical records were evaluated to determine when the MGTs were initially diagnosed. Any preoperative diagnostics performed (CBC, serum biochemistry, thoracic radiographs, abdominal ultrasound) were also recorded for all dogs. Regional lymph node evaluation (via either cytology or histopathology) was rarely performed in this population of dogs but was recorded when available.

One hundred forty-three dogs had MGTs removed during the study period. There were 96 dogs that met the inclusion criteria. Of these, 44 of 96 dogs (46%) were presented with incidental MGTs, and 52 of 96 dogs (54%) were presented with nonincidental MGTs. Of the dogs with incidental MGTs, 33 of 44 (75%) were presented for pyometra, and 11 of 44 (25%) were presented for other causes. These 11 dogs were presented for various other reasons: 7 were presented for a separate reproductive issue (vaginal mass [n = 3], persistent vaginal discharge that was not consistent with a diagnosis of pyometra [2], pregnancy with a dead fetus [1], and pseudopregnancy/mastitis [1]), 2 were presented for tumors elsewhere in the body (1 each in the maxilla and tarsus), and 1 each were presented for gastric dilatation-volvulus and cranial cruciate ligament tear.

The most common benign histopathologic diagnoses were complex adenoma (n = 48), simple adenoma (31), benign mixed tumor (30), and basaloid (ductal) adenoma (30). The most common malignant histopathologic diagnosis was simple carcinoma (n = 24). The most common nonneoplastic histopathologic diagnosis was mammary hyperplasia (lobular, ductal, and/or cystic) (n = 6). Nonneoplastic results were included in the analysis as benign tumors.

In dogs that were presented for pyometra with incidental MGTs, 28 of 33 (85%) had only benign MGTs, and 5 of 33 (15%) had at least 1 malignant MGT. There were 61 of 66 (92%) benign tumors and 5 of 66 (8%) malignant tumors in this group of dogs. In the dogs that were presented for causes other than MGT removal or pyometra and had incidental MGTs, 10 of 11 (91%) had only benign MGTs, and 1 of 11 (9%) had at least 1 malignant MGT. There were 21 of 22 (95%) benign tumors and 1 of 22 (5%) malignant tumors in this group of dogs. When combining all dogs with incidental MGTs, 38 of 44 (86%) had only benign MGTs, and 6 of 44 (14%) had at least 1 malignant MGT. There were 82 of 88 (93%) benign incidental MGTs and 6 of 88 (7%) malignant incidental MGTs. In the dogs that were presented with nonincidental MGTs, 25 of 52 (48%) had only benign MGTs, and 27 of 52 (52%) had at least 1 malignant MGT. There were 75 of 107 (70%) benign nonincidental MGTs and 32 of 107 (30%) malignant nonincidental MGTs. These findings are summarized on a per-dog evaluation (Table 1) and on a per-tumor evaluation (Table 2).

Comparison of malignancy rates per tumor between nonincidental and incidental groups (n = 195 tumors). Nonincidental MGTs were significantly (OR, 5.83; 95% CI, 2.31 to 14.73; P = .001) more likely to be malignant, compared with incidental MGTs.

Size of MGTs was available for 158 of 195 tumors (81%), which included at least 1 tumor from all 96 dogs (Table 4). The proportion of T3 tumors that were malignant (63% [19/30 MGTs]) was significantly greater (P = .001) than the proportion of T1 tumors that were malignant (7% [8/115 MGTs]). In dogs that were presented for pyometra with incidental MGTs, 47 of 52 (90%) MGTs with a documented size were in T1, 3 of 52 (6%) were in T2, and 2 of 52 (4%) were in T3. All (21/21) the incidental MGTs in dogs without concurrent pyometra were in T1. In dogs that were presented with nonincidental MGTs, 47 of 85 (55%) MGTs were in T1, 10 of 85 (12%) were in T2, and 28 of 85 (33%) were in T3. The proportion of incidental tumors that were in T1 (68/73 [93%]) was significantly greater (P = .001; Table 5) than the proportion of nonincidental tumors that were in T1 (47/85 [55%]). e24fc04721