2025

1. Janice Lay Tin Tan, Masaya Shimabukuro, Akira Tsuchiya, W. M. Ruvini Lasanthika Kumari Wijekoon, Ryo Kishida, Masakazu Kawashita, Kunio Ishikawa
   "Influence of progens on architecture and osteogenesis of porous carbonate apatite artificial bones."
   Ceram. Int., in press. DOI: 10.1016/j.ceramint.2025.02.162

2. Saki Takeda, Akira Tsuchiya, Masafumi Moriyama, Kunio Ishikawa
   "Optimization of the structure of three-dimensional interconnected porous carbonate apatite bone grafts with spherical granules."
   Dent. Mater. J. 2025, 44, 233-240. DOI: 10.4012/dmj.2024-325

3.  Seojung Cho, Miyuki Hori, Ryosuke Ueki, Yutaro Saito, Yukiko Nagai, Haruka Iki, Akira Tsuchiya, Tomohiro Konno, Kensuke Owari, Haishun Piao, Kazunobu Futami, Shinsuke Sando
   "Zwitterionic polymer with minimal reactivity against PEG antibodies to enhance the therapeutic effects of cytokine-targeting DNA aptamer."
   Biomater. Sci. 2025, 13, 1347-1353. DOI: 10.1039/D4BM01541J

4. Miki Morinobu, Akira Tsuchiya, Masaya Shimabukuro, Masafumi Moriyama, Kunio Ishikawa
   "Antibacterial and Anti-inflammation Activity of Titanium Alloy by Efficient Copper Immobilization."
   Langmuir 2025, 41, 2892-2898. DOI: 10.1021/acs.langmuir.4c04782

5. Zhanrui Lou, Akira Tsuchiya, Masaya Shimabukuro, Ryo Kishida, Kunio Ishikawa
   "Fabrication and histological evaluation of unidirectional porous carbonate apatite granules for bone grafting."
   Ceram. Int. 2025, 51, 13860-13870. DOI: 10.1016/j.ceramint.2025.01.220

2024

1. Saki Takeda, Akira Tsuchiya, Masafumi Moriyama, Kunio Ishikawa
   "Physical and histological comparison of three-dimensional interconnected porous carbonate apatite bone graft fabricated with cylindrical and spherical granules."
   Ceram. Int. 2024, 50, 53544-53551. DOI: 10.1016/j.ceramint.2024.10.203

2. Riki Toita, Yuki Shimizu, Eiko Shimizu, Tomonori Deguchi, Akira Tsuchiya, Jeong-Hun Kang, Masahiro Kitamura, Atsuchi Kato, Hideto Yamada, Shogo Yamaguchi, Shinjiro Kasahara
   "Collagen patches releasing phosphatidylserine liposomes guide M1-to-M2 macrophage polarization and accelerate simultaneous bone and muscle healing."
   Acta Biomater. 2024, 187, 51-65. DOI: 10.1016/j.actbio.2024.08.012

3. Koichiro Hayashi, Masaya Shimabukuro, Cheng Zhang, Ahmad Nazir Taleb Alashkar, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa
   "Silver phosphate-modified carbonate apatite honeycomb scaffolds for anti-infective and pigmentation-free bone tissue engineering."
   Mater. Today Bio 2024, 27, 101161. DOI: 10.1016/j.mtbio.2024.101161

4. Luis Miguel Torres Escalante, Akira Tsuchiya, Lou Zhanrui, Miki Morinobu, Kunio Ishikawa
   "Fabrication and histological evaluation of a self-setting granular cement using calcium sulfate hemihydrate granules with different pore distribution."
   Dent. Mater. J. 2024, 34, 573-581. DOI: 10.4012/dmj.2023-248

5. Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa
   "Hematopoietic fuction restoration by transplanting bone marrow niches in vivo engineering using carbonate apatite honeycomb bioreactors."
   Small Struct. 2024, 5, 2499965. DOI: 10.1002/sstr.202400065

6. Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa
   "Transformable carbonate apatite chains as a novel type of bone graft."
   Adv. Health. Mater. 2024, 13, 2303245. DOI: 10.1002/adhm.202303245

2023

1. Riki Toita, Masahiro Kitamura, Akira Tsuchiya, Jeong-Hun Kang, Shinjiro Kasahara
   "Releasable, immune-instructive, bioinspired multylayer coating resists implant-induced fibrosis while accelerating tissue repair."
   Adv. Health. Mater. 2023, 13, 2302611. DOI: 10.1002/adhm.202302611

2. Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa
   "Effects of space dimensionality within scaffold for bone regeneration with large and priented blood vessels."
   Materials 2023, 16, 7518. DOI: 10.3390/ma16247518

3. Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa
   "Superiority of triply periodic minimal surface gyroid structre to strut-based grid structure in both strength and bone regeneration."
   ACS Appl. Mater. Inter. 2023, 15, 34570-34577. DOI: 10.1021/acsami.3c06263

4. Koichiro Hayashi, Toshiki Yanagisawa, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa
   "Gear-shaped carbonate apatite granules with a hexagonal macropore for rapid bone regeneration."
   Biotechnol. J. 2023, 21, 2514-2523. DOI:10.1016/j.csbj.2023.03.053

2022

1.  Riki Toita, Jeong-Hun Kang, Akira Tsuchiya
   "Phosphatidylserine liposome multilayers mediate the M1-to M2 macrphage polarization to enhance bone tissue regeneration."
   Acta Biomater. 2022, 154, 584-596. DOI: 10.1016/j.actbio.2022.10.024

2. Koichiro Hayashi, Masaya Shimabukuro, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa
   "Structurally optimized honeycomb scaffolds with outstanding ability for vertical bone augmentation."
   J. Adv. Res. 2022, 41, 101-112. DOI: 10.1016/j.jare.2021.12.010

3. Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa
   "Channel aperture characteristics of carbonate apatite honeycomb scaffolds affect ingrowths of bone and fibrous tissues in vertical bone augmentation."
   Bioengineer. 2022, 9, 627. DOI: 10.3390/bioengineering9110627

4. Keisuke Tanaka, Akira Tsuchiya, Yoichiro Ogino, Yasunori Ayukawa, Kunio Ishikawa
   "Comparison of calcite and vaterite as precursors for CO3Ap artificial bone fabrication through a dissolution-precipitation reaction."
   Ceram. Int. 2022, 48, 26425-26431. DOI: 10.1016/j.ceramint.2022.05.336

5. Maab Elsheikh, Ryo Kishida, Koichiro Hayashi, Akira Tsuchiya Masaya Shimabukuro, Kunio Ishikawa
   "Effect of pore interconnectivity on bone regeneration in carbonate apatite blocks."
   Regen. Biomater. 2022, 9, rbac010. DOI: 10.1093/rb/rbac010

6. Akira Tsuchiya, Perry Pinheiro Freitas, Nozomi Nagashima, Kunio Ishikawa
   "Influence of pH and ion components in the liquid phase on the setting reaction of carbonate apatite granules."
   Dent. Mater. J. 2022, 41, 209-213. DOI: 10.4012/dmj.2021-211

7. Masaya Shimabukuro, Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa
   "Surface functionalization with copper endows carbonate apatite honeycomb scaffold with articial, proangiogenic, and pro-osteogenic activities."
   Biomater. Adv. 2022, 135, 212751. DOI: 10.1016/j.bioadv.2022.212751

8. Koichiro Hayashi, Akira Tsuchiya, Masaya Shimabukuro, Kunio Ishikawa
   "Multiscale porous scaffolds constructed of carbonate apatite honeycomb granules for bone regeneration."
   Mater. Design 2022, 215, 110468. DOI: 10.1016/j.matdes.2022.110468

9. Pery Pinheiro Freitas, Ryo Kishida, Koichiro Hayashi, Akira Tsuchiya, Masaya Shimabukuro, Kunio Ishikawa
   "Fabrication and histological evaluation of porous carbonate apatite blocks using disodium hydrogen phosphate crystals as a porogen and phosphatization accelerator."
   J. Biomed. Mater. Res. part A 2022, 110, 1278-1290. DOI: 10.1002/jbm.a.37374

10. Kunio Ishikawa, Pery Pinheiro Freitas, Ryo Kishida, Koichiro Hayashi, Akira Tsuchiya
    "Fabrication of vaterite blocks from a calcium hydroxide compact."
    Ceram. Int. 2022, 48, 4153-5157. DOI: 10.1016/j.ceramint.2021.10.206

11. Masaya Shimabukuro, Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa
    "No-observed-effect level of silver phosphate in carbonate apatite artificial bone on initial bone regeneration."
    ACS Infect. Dis. 2022, 8, 159-169. DOI: 10.1021/acsinfecdis.1c00480

12. Kaai Deguchi, Shunsuke Nomura, Akira Tsuchiya, Ichiro Takahashi, Kunio Ishikawa
    "Effects of the carbonate content in carbonate apatite on bone replacement."
    Regen.Med. 2022, 16, 200-206. DOI: 10.1002/term.3270

13. Yuki Sugiura, Masanori Horie, Akira Tsuchiya, Yoji Makita
    "Specific roles of sodium for the formation process of manganese-substituted octacalcium phosphate."
    Am. Mineral. 2022, 107, 896-903. DOI: 10.2138/am-2021-7901

14. Masaya Shimabukuro, Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa
    "Effects of carbonate apatite ions in phosphate solution on the fabrication of carbonate apatite through a dissolution-precipitation reaction."
    Ceram. Int. 2022, 48, 1032-1037. DOI: 10.1016/ceramint.2021.09.188

2021

1. Sunarso, Akira Tsuchiya, Riki Toita, Kanji Tsuru, Kunio Ishikawa
   "Impact of surface functionalization with phosphate and calcium on the biological performance of Ti-6Al-4V."
   Mater. Lett. 2021, 304, 130716. DOI: 10.1016/j.matlet.2021.130716

2. Ryo Kishida, Maab Elsheikh, Koichiro Hayashi, Akira Tsuchiya, Kunio Ishikawa
   "Fabrication of highly interconnected porous carbonate apatite blocks based on the setting reaction of calcium sulfate hemihydrate granules."
   Ceram. Int. 2021, 47, 19856-19863. DOI: 10.1016/j.ceramint.2021.03.324

3. Taiga Ono, Atsushi Tomokiyo, Keita Ipposhi, Kozue Yamashita, M. Anas Alhasan, Yudai Miyazaki, Yoshihiro Kunitomi, AkiraTsuchiya, Kunio Ishikawa, Hidefumi Maeda
   "Generation of biohybrid implants using a multipotent human periodontal ligament cell line and bioactive core materials."
   J. Cell. Phys. 2021, 236, 6742-6753. DOI: 10.1002/jcp.30336

4. Koichiro Hayashi, Masaya Shimabukuro, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa
   "Honeycomb scaffolds capable of achieving barrier membrane-free guided bone regeneration."
   Mater. Adv. 2021, 2, 7638-7649. DOI: 10.1039/d1ma00698c

5. Kozue Yamashita, Atsushi Tomokiyo, Taiga Ono, Keita Ipposhi, M. Anas Alhasan, Akira Tsuchiya, Sayuri Hamano, Hideki Sugii, Sshinichiro Yoshida, Tomohiro Itoyama, Hirofumi Maeda
   "Mineral trioxide aggregation immersed in sodium hypochlorite reduce the osteoblastic differentiation of human periodontal ligament stem cells."
   Sci. Rep. 2021, 11, 22091. DOI: 10.1038/s41598-021-01545-3

6. Yuta Sakemi, Koichiro Hayashi, Akira Tsuchiya, Yasuharu Nakashima, Kunio Ishikawa
   "Reconstruction of critical-size segmental defects in rat femurs using carbonate apatite honeycomb scaffolds."
   J. Biomed. Mater. Res. part A 2021, 109, 1613-1622. DOI: 10.1002/jbm.a.37157

2020

1. Sunarso, Akira Tsuchiya, Riki Toita, Kanji Tsuru, Kunio Ishikawa
   "Enhanced osseointegration capability of poly(Ether ether ketone) via combined phosphate and calcium surface-functionalization."
   Int. J. Mol. Sci. 2020, 21, 198. DOI: 10.3390/ijms21010198

2. Keisuke Tanaka, Akira Tsuchiya, Yoichiro Ogino, Kiyoshi Koyano, Kunio Ishikawa
   "Fabrication and histological evaluation of a fully interconnected porous CO3Ap block formed by hydrate expansion of CaO granules."
   ACS Appl. Bio Mater. 2020, 3, 8872-8878. DOI: 10.1021/acsabm.0c01176

3. Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa
   "Granular honeycombs composed of carbonate apatite, hydroxyapatite, and β-tricalcium phosphate as bone graft substitutes: Effect of composition on bone formation and maturation."
   ACS Appl. Bio. Mater. 2020, 3, 1787-1785. DOI: 10.1021/acsabm.0c00060

2019

1. Koichiro Hayashi, Ryo Kishida, A.kira Tsuchiya, Kunio Ishikawa
   "Carbonate apatite micro-honeycombed blocks generate bone marrow-like tissues as well as bone."
   Adv. Biosystems 2019, 3, 1900140. DOI: 10.1002/adbi.201900140

2. Yuta Sakemi, Koichiro Hayashi, Akira Tsuchiya, Yasuharu Nakashima, Kunio Ishikawa
   "Fabrication and histological evaluation of porous carbonate apatite block from gypsum block containing spherical phenol resin as a porogen."
   Materials 2019, 12, 3997. DOI: 10.3390/ma12233997

3. Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa
   "Honeycomb blocks composed of carbonate apatite, β-tricalcium phosphate, and hydroxyapatite for bone regeneration: effect of composition on biological response."
   Mater. Today Bio 2019, 4, 100031. DOI: 10.1016/j.mtbio.2019.100031

4. Naoyuki Fukuda, Akira Tsuchiya, Sunarso, Riki Toita, Yoshihide Mori, Kunio Ishikawa
   "Surface plasma treatment and phosphorylation enhance the biological performance of poly(ether ether ketone)."
   Colloids Surf. B 2019, 173, 36-42. DOI: 10.1016/j.colsurfb.2018.09.032

2018

1. Naoyuki Fukuda, Masayuki Kanazawa, Kanji Tsuru, Akira Tsuchiya, Sunarso, Riki Toita, Yoshihide Mori, Yasuharu Nakashima, Kunio Ishikawa
   "Synergistic effect of surface phosphorylation and micro-roughness on enhanced bone integration ability of poly(ether ether ketone) in the rabbit tibia."
   Sci. Rep. 2018, 8, 16887. DOI: 10.1016/j.colsurfb.2018.09.032

2. Eddy, Akira Tsuchiya, Kanji Tsuru, Kunio Ishikawa
   "Fabrication of self-setting β-TCP granular cement using β-TCP granules and sodium hydrogen sulfate solution."
   J. Biomater. Appl. 2018, 33, 630-636. DOI: 10.1177/0885328218808015

3. Akira Tsuchiya, Marino Sato, Ichiro Takahashi, Kunio Ishikawa
   "Fabrication of apatite-coated gypsum granules and histological evaluation using rabbits."
   Ceram. Int. 2018, 44, 20330-20336. DOI: 10.1016/j.ceramint.2018.08.021

4. Sunarso, Akira Tsuchiya, Naoyuki Fukuda, Riki Toita, Kanji Tsuru, Kunio Ishikawa
   "Effect of micro-roughening of poly(ether ether ketone) on bone marrow derived stem cell and macrophage responses, and osseointegration."
   J. Biomater. Sci.: Polym. Ed. 2018, 29, 1375-1388. DOI: 10.1080/09205063.2018.1461448

5. Kunio Ishikawa, Youji Miyamoto, Akira Tsuchiya, Koichiro Hayashi, Kanji Tsuru, Go Ohe
   "Physical and histological comparison of hydroxyapatite, carbonate apatite, and　β-tricalcium phosphate bone substitutes."
   Materials 2018, 11, E1993. DOI: 10.3390/ma11101993

6. Kunio Ishikawa, Tansza Setiana Putri, Akira Tsuchiya, Keisuke Tanaka, Kanji Tsuru
   "Fabrication of interconnected porous β-tricalcium phosphate (β-TCP) based on a setting reaction of β-TCP granules with HNO3 followed by heat treatment."
   J. Biomed. Mater. Res. part A 2018, 106, 797-804. DOI: 10.1002/jbm.a.36285

2017

1. Akira Tsuchiya, Jeong-Hun Kang, Takeshi Mori, Yuki Naritomi, Satoshi Kushio, Takuro Niidome, Katsuro Tachibana, Yoko Takahashi, Youichi Negishi, Yusuke Oda, Ryo Suzuki, Kazuo Maruyama, Yoshiki Katayama
   "Efficient delivery of signal-responsive gene carriers for disease-specific gene expression via bubble liposomes and sonoporation." Coll. Surf. B 2017, 160, 60-64. DOI: 10.1016/j.colsurfb.2017.09.021

2016

1. Akira Tsuchiya, Siti N. Hashim, Shoko Ise, Takafumi Furuhata, Kiyohiko Kawai, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya, Shinsuke Sando
   "BODIPY-labeled fluorescent aptamer sensors for turn-on sensing of interferon-gamma and adenine compounds on cells."
   Anal. Sci. 2016, 32, 543-547. DOI: 10.2116/analsci.32.543

2015

1. Siti. N. Hashim, Akira Tsuchiya, Noriho Kamiya, Shinsuke Sando
   "Fluorophore-labeled aptamer sensor for the detection of interferon gamma."
   Chem. Lett. 2015, 44, 1670-1672. DOI: 10.1246/cl.150794

2. Hiroshi Nonaka, Qi An, Fuminori Sugihara, Tomohiro Doura, Akira Tsuchiya, Yoshichika Yoshioka, Shinsuke Sando
   "Phenylboronic acid-based 19F MRI probe for the detection and imaging of hydrogen peroxide utilizing its large chemical shift change."
   Anal. Sci. 2015, 31, 331-335. DOI: 10.2116/analsci.31.331

2014以前

1. Yuta Nakamura, Chan W. Kim, Akira Tsuchiya, Satoshi Kushio, Takanobu Nobori, Kai Li, Eun K. Lee, Guo X. Zhao, Daiki Funamoto, Takuro Niidome, Takeshi Mori, Yoshiki Katayama
   "Branched polyethylenimine-based PKCα-responsive gene carriers."
   J. Biomater. Sci-Polym. Ed. 2013, 24, 1858-1868. DOI: 10.1080/09205063.2013.807459

2. Satoshi Kushio, Akira Tsuchiya, Yuta Nakamura, Chan W. Kim, Guo X. Zhao, Daiki Funamoto, Eun K. Lee, Takuro Niidome,
   Takeshi Mori, Yoshiki Katayama
   "Cancer-specific gene carriers responding to cancer microenvironment: acidosis and hyper-activated protein kinases."
   Biomedical Engineering 2013, 25, 1340005-13400016. DOI: 10.4015/S101623721340005X

3. Akira Tsuchiya, Yuki Naritomi, Satoshi Kushio, Jeong-Hun Kang, Masaharu Murata, Makoto Hashizume, Takeshi Mori,
   Takuro Niidome, Yoshiki Katayama
   "Improvement in the colloidal stability of protein kinase-responsive polyplexes by PEG modification."
   J. Biomed. Mater. Res. A 2012, 100, 1136-1141. DOI: 10.1002/jbm.a.34049

4.  Akira Tsuchiya, Daisuke Asai, Jeong-Hun Kang, Takeshi Mori, Takuro Niidome, Yoshiki Katayama
   "Correlation between phosphorylation ratios by MALDI-TOF MS analysis and radioactivities by radioactive assay."
   Anal. Biochem. 2012, 421, 773-775. DOI: 10.1016/j.ab.2011.08.035

5. Hidetoshi Arima, Ayumi Yoshimatsu, Haruna Ikeda, Ayumu Ohyama, Keiichi Motoyama, Taishi Higashi, Akira Tsuchiya,
   Takuro Niidome, Yoshiki Katayama, Kenjiro Hattori, Tomoko Takeuchi
   "Folate-PEG-Appended Dendrimer Conjugate with alpha-Cyclodextrin as a Novel Cancer Cell-Selective siRNA Delivery Carrier."
   Mol. Pharm. 2012, 9, 2591-2604. DOI: 10.1021/mp300188f

6. Akira Tsuchiya, Jeong-Hun Kang, Daisuke Asai, Takeshi Mori, Takuro Niidome, Yoshiki Katayama
   "Transgene regulation system responding to Rho associated coiled-coil kinase (ROCK) activation."
   J. Control. Release 2011, 155, 40-46. DOI: 10.1016/j.jconrel.2011.05.002

7. Jeong-Hun Kang, Daisuke Asai, Akira Tsuchiya, Takeshi Mori, Takuro Niidome, Yoshiki Katayama
   "Peptide substrates for Rho-associated kinase 2 (Rho-kinase 2/ROCK2)."
   PLoS ONE 2011, 6, e22699. DOI: 10.1371/journal.pone.0022699

8. Jun Oishi, Joohee Jung, Akira Tsuchiya, Riki Toita, Jeong-Hun Kang, Takeshi Mori, Takuro Niidome, Katsuyuki Tanizawa,
   Shunichi Kuroda, Yoshiki Katayama
   "A gene delivery system specific for hepatoma cells and an intracellular kinase signal based on human liver-specific bionanocapsules and signal-responsive artificial polymer."
   Int. J. Pharm. 2010, 396, 174-178. DOI: 10.1016/j.ijpharm.2010.06.012

9. Daisuke Asai, Akira Tsuchiya, Jeong-Hun Kang, Kenji Kawamura, Jun Oishi, Takeshi Mori, Takuro Niidome, Yoko Shoji,
   Hideki Nakashima, Yoshiki Katayama
   "Inflammatory cell-specific gene regulation system responding to Ikappa-B kinase beta activation."
   J. Gene Med. 2009, 11, 624-632. DOI: 10.1002/jgm.1342

10. Daisuke Asai, Jeong-Hun Kang, Riki Toita, Akira Tsuchiya, Takuro Niidome, Hideki Nakashima, Yoshiki Katayama
    "Regulation of Transgene Expression in Tumor Cells by Exploiting Endogenous Intracellular Signals."
    Nanoscale Res. Lett. 2009, 4, 229-233. DOI: 10.1007/s11671-008-9230-5

11. Jeong-Hun Kang, Masanori Kuramoto, Akira Tsuchiya, Riki Toita, Daisuke Asai, Yuko T. Sato, Takeshi Mori, Takuro Niidome,
    Yoshiki Katayama
    "Correlation between phosphorylation ratios by MALDI-TOF MS analysis and enzyme kinetics."
    Eur. J. Mass Spectrom. 2008, 14, 261-265.  DOI: 10.1255/ejms.916