Embedded Files
A chaperone and a heat-resistant obscure (Hero) protein mediates conformational extension and aggregation suppression of TDP-43, Lam, Tsuboyama* (Co-Correspondence), Tadakuma* and Tomari*
A chaperone and a heat-resistant obscure (Hero) protein mediates conformational extension and aggregation suppression of TDP-43, Lam, Tsuboyama* (Co-Correspondence), Tadakuma* and Tomari*
@Rocklin lab (Northwestern University)
Mega-scale experimental analysis of protein folding stability in biology and protein design, Tsuboyama et al. 2023 Nature (Article Link)
Mega-scale experimental analysis of protein folding stability in biology and protein design, Tsuboyama et al. 2023 Nature (Article Link)
Folding stability is centrally important in biochemistry and influences almost all other protein properties. Our new approach can measure the folding stability of ~ a million different proteins in approximately one week. Using such huge data, we have analyzed, for example, how folding stability affects amino acid usage in natural proteins.
タンパク質の構造安定性は、ほとんどあらゆるタンパク質の性質に影響を与えるような最も重要な形質の一つです。私達が構築した新たな測定法により、100万種類程度のタンパク質の構造安定性をおおよそ1週間で測定することが可能です。このような巨大データを用いて、例えば構造安定性が天然タンパク質におけるアミノ酸の使用率にどのような影響を与えるかの解析なども行いました。
Dissecting the stability determinants of a challenging de novo protein fold using massively parallel design and experimentation, Kim*, Tsuboyama* et al. PNAS 2022 (Article Link)
Dissecting the stability determinants of a challenging de novo protein fold using massively parallel design and experimentation, Kim*, Tsuboyama* et al. PNAS 2022 (Article Link)
@Tomari Lab (UTokyo)
A widespread family of heat-resistant obscure (Hero) proteins protect against protein instability and aggregation, Tsuboyama# (co-corresponding) et al. PLOS BIOLOGY 2020 (Article Link)
A widespread family of heat-resistant obscure (Hero) proteins protect against protein instability and aggregation, Tsuboyama# (co-corresponding) et al. PLOS BIOLOGY 2020 (Article Link)
Conformational activation of Argonaute by distinct yet coordinated actions of the Hsp70 and Hsp90 chaperone systems, Tsuboyama et al. 2018 Molecular Cell (Article Link)
Conformational activation of Argonaute by distinct yet coordinated actions of the Hsp70 and Hsp90 chaperone systems, Tsuboyama et al. 2018 Molecular Cell (Article Link)
@Mizushima Lab (UTokyo)
The ATG conjugation systems are important for degradation of the inner autophagosomal membrane, Tsuboyama*, Koyama-Honda* et al. Science 2016 (Article Link)
The ATG conjugation systems are important for degradation of the inner autophagosomal membrane, Tsuboyama*, Koyama-Honda* et al. Science 2016 (Article Link)
Page updated
Google Sites
Report abuse