Research Projects

• 科学研究費基盤研究(B)　研究代表　(2024-26年度)

  「テクノロジー・マネジメントにおけるオープンイノベーション戦略の影響」
 

• 科学研究費基盤研究(B)　分担研究者　 (2022-24年度)

  「制度・規制とイノベーション」

• 科学研究費基盤研究(A)　分担研究者　(2024-26年度)

  「購買行動における時間割引における香りの効果」

• 三井住友銀行国際協力財団　調査・研究助成事業　(2024年度)

「デジタル技術の進展がアジア諸国の農業・食品産業におけるオープン・イノベーションに及ぼす影響」

Topics of Project Reports

• 医療機器業界に於ける中小企業が、コモディティ化を回避する方法について

• 次世代エアモビリティの社会実装に向けた社会受容性向上

• 企業研究者のウェルビーイングに関する研究

• オンライン科学技術コンテンツの構成形式と言語内翻訳に関する事例分析

• 日本のコンテンツ産業における新規IP創出と事業成功に向けた方法論の検討

• 情報通信技術を用いた医療情報システムが病院の経営に与える影響とその過程を見据えた病院経営戦略の研究

Achievements before launch

• Miyaki T, Imada T, Hao SS, Kimura E.; Monosodium L-glutamate in soup reduces  subsequent energy intake from high-fat savory food in overweight and obese  women, Br J Nutr. 2016 Jan 14;115(1):176-84

• Imada T, Hao SS, Torii K, Kimura E.; Supplementing chicken broth with  monosodium glutamate reduces energy intake from high fat and sweet snacks in  middle-aged healthy women., Appetite. 2014 Aug;79:158-65. 

• アミノ酸科学の最前線-基礎研究を活かした応用戦略 第 3 章－1 アミノ酸の製造方法／シーエムシー出版（2014）P.118-126

• Wilson AM, Kimura E, Harada RK, Nair N, Narasimhan B, Meng XY, Zhang F, Beck KR, Olin JW, Fung ET, Cooke JP. : Beta 2 microglobulin is a potential biomarker for diagnosis of peripheral arterial disease; Circulation Circulation. 2007 Sep 18;116(12):1396-403. 

• Nishio Y., Nakamura Y., Kawarabayashi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., and Gojyobori T.: Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiencs ; Genome Research, No. 13, p. 1572-1579 (2003) 

〇受賞歴

2006 Young Investors Award, Society of Vascular Medicine and Biology (2006) 

2000 Award for Excellence to Authors Publishing in Bioscience, Biotechnology and Biochemistry

〇レビューおよび著書

●アミノ酸科学の最前線-基礎研究を活かした応用戦略　第3章　アミノ酸の製造方法／シーエムシー出版（2014）

●アミノ酸の科学と最新応用技術 第3章　アミノ酸の製造方法/ シーエムシー出版　（2008）

●木村英一郎、ジョン P. クック、新規の動脈硬化症診断バイオマーカーの探索と臨床展開、バイオサイエンスとインダストリー　（2008）

● Kimura E.: Glutamate Production; Handbook of Corynebacterium glutamicum; CRC Press (2005)

● Kimura E.: Metabolic Engineering of Glutamate Production; Advances in Biochemical Engineering/Biotechnology, R. Faurie (ed), Vol. 79, p. 38-57, Springer-Verlag, Berlin, Heidelberg（2003）

● Kimura E.: Triggering mechanism of L-glutamate overproduction by DtsR1 in Coryneform Bacteria; Journal of Bioscience and Bioengineering, No. 94, p.545-551(2002)

●発酵ハンドブック／共立出版　バイオインダストリー協会監修　グルタミン酸（2001）

● Kimura E., Kawahara Y., and Nakamatsu T.: The mechanism of glutamate overproduction by coryneform bacteria; Protein, Nucleotic acid, Enzymes, No. 42, p.2633-2640 (1997)

● Kimura E., Kawahara Y., and Nakamatsu T.: The triggering mechanism of L-glutamate overproduction by Corynebacterium glutamicum; Bioscience & Industry, No.55, p.27-30 (1997)

〇オリジナル投稿

●Miyaki T, Imada T, Hao SS, Kimura E.; Monosodium L-glutamate in soup reduces subsequent energy intake from high-fat savory food in overweight and obese women, Br J Nutr. 2016 Jan 14;115(1):176-84.

●Kawano R, Ishida M, Kimura E, Matsumoto H, Arai H.; Pilot intervention study of a low-salt diet with monomagnesium di-L-glutamate as an umami seasoning in psychiatric inpatients., Psychogeriatrics. 2015 Mar;15(1):38-42.

●Imada T, Hao SS, Torii K, Kimura E.; Supplementing chicken broth with monosodium glutamate reduces energy intake from high fat and sweet snacks in middle-aged healthy women., Appetite. 2014 Aug;79:158-65.

●San Gabriel A., Kimura E, et al., Umami Taste research and beyond: Nature, Nature Outlook, 2012

●Shimogoryo R, Eguro T, Kimura E, Maruta M, Matsuya S, Ishikawa K.; Effects of added mannitol on the setting reaction and mechanical strength of apatite cement., Dent Mater J. 2009 Sep;28(5):627-33.

●Asakura Y, Kimura E, Usuda Y, Kawahara Y, Matsui K, Osumi T, Nakamatsu T. Altered metabolic flux due to deletion of odhA causes L-glutamate overproduction in Corynebacterium glutamicum. Appl Environ Microbiol. 2007 Feb;73(4):1308-19.

●Nakamura J, Kanno S, Kimura E, Matsui K, Nakamatsu T, Wachi M. Temperature-sensitive cloning vector for Corynebacterium glutamicum. Plasmid. 2006 Nov;56(3):179-86.

●Wilson AM, Kimura E, Harada RK, Nair N, Narasimhan B, Meng XY, Zhang F, Beck KR, Olin JW, Fung ET, Cooke JP. : Beta 2 microglobulin is a potential biomarker for diagnosis of peripheral arterial disease; Circulation Circulation. 2007 Sep 18;116(12):1396-403.

● Shirai T, Nakato A, Izutani N, Nagahisa K, Shioya S, Kimura E, Kawarabayasi Y, Yamagishi A, Gojobori T, Shimizu H. Comparative study of flux redistribution of metabolic pathway in glutamate production by two coryneform bacteria.  Metab Eng. 2005 Mar;7(2):59-69.

● Nishio Y., Nakamura Y., Kawarabayashi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., and Gojyobori T.: Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiencs; Genome Research, No. 13, p. 1572-1579 (2003)

● Shimizu H., Tanaka H., Nakato A., Nagahisa K., Kimura E., and Shioya S.: Effects of the changes in enzyme activities on metabolic flux redistribution around the 2-oxoglutarate branch in glutamate production by Corynebacterium glutamicum; Bioprocess, Biosystem Engineering, No. 25, p. 291-298 (2003)

● Fudou R., Jojima Y., Seto A., Yamada K., Kimura E., Nakamatsu T., Hiraishi A., and Yamanaka S.: Corynebacterium efficiens sp. nov., a glutamic acid-producing species from soil and vegetables; Inter. J. System Evolutionary Microbiology, No. 52, p. 1127-1131 (2002) 

● Kimura E., Yagoshi, C., Kawahara Y., Ohsumi T., Tsuyoshi N., and Tokuda H.: Glutamate overproduction in Corynebacterium glutamicum is triggered by decrease in the level of a complex comprising DtsR and biotin-containing subunit; Bioscience, Biotechnology and Biochemistry, No. 63, p. 1274-1278 (1999)

● Kimura E., Kawahara Y., and Nakamatsu T.: Studies of L-glutamate-production in coryneform bacteria by using metabolic-flux analysis; 7th International Conference on Computer Applications in Biotechnology, p.393-397(1998)

● Kimura E., Abe C., Kawahara Y., Nakamatsu T., and Tokuda H.: A dtsR gene-disrupted mutant of Brevibacterium lactofermentum requires fatty acids for growth and efficiently produces L-glutamate in the presence of an excess of biotin; Biochemistry, Biophysics Research Community, No. 234, p. 157-161 (1997)

● Kimura E., Abe C., Kawahara Y., and Nakamatsu T.: Molecular cloning of a novel gene, dtsR, which rescues the detergent sensitivity of a mutant derived from Brevibacterium lactofermentum; Bioscience, Biotechnology and Biochemistry, No. 60, p.1565-1570(1996)

● Usuda Y., Tujimoto N., Abe C., Asakura Y., Kimura E., Kawahara Y., Kurahashi O., and Matsui H.: Molecular cloning of the Corynebacterium glutamicum (‘Brevibacterium lactofermentum’ AJ12036) odhA gene encoding a novel type of 2-oxoglutarate dehydrogenase; Microbiology, No. 142, p. 3347-3354 (1996)

● Kimura E., Akita M., Matsuyama S., and Mizushima S.: Determination of a region in SecA that Interacts with pre-secretory protein in Escherichia coli; Journal of Biology and Chemistry, No. 266, p. 6600-6606 (1990)

● Matsuyama S., Kimura E., and Mizushima S.: Complementation of two overlapping fragments of SecA, a protein translocation ATPase of Escherichia coli, allows ATP binding to its amino-terminal region; Journal of Biology and Chemistry, No. 265, p. 8760-8765 (1990)

〇招待講演（シンポジウム等）

● JETRO Los Angels主催　全国中小企業団体中央会北米セミナー　(北米企業のM&AとPMI、オープンイノベーション)　(United States, 2017)

● Berkeley Innovation Forum at UC Berkeley Haas School of Business　(オープンイノベーション) (United States, 2012)

● Institute of Food Technology (United States, 2011)

● ASEAN Food Conference (Malaysia, 2007)

● Japan Society for Bioscience, Biotechnology, and Agrochemistry (2006)

● Japan Society for Bioscience, Biotechnology, and Agrochemistry (2000)

● Japan Society for Bioscience, Biotechnology, and Agrochemistry (1997)

● 2nd International Conference on the Research Frontier of Microbial Genome Analysis (1997)

〇主な国際学会での発表

● American College of Cardiology (United States, 2006)

● Society for Vascular Medicine and Biology (United States, 2006)

● The Human Proteome, Cambridge Health Institute (United Stats, 2006)

● Society for Vascular Medicine and Biology (United States, 2005)

● American Heart Association (United States, 2005)

● Metabolic Engineering III Workshop (United States, 2000)

● Metabolic Engineering III Workshop (United States, 2000)

● Metabolic Engineering II (Germany, 1998)

● Computer Applications in Biotechnology 7 (Japan, 1997)

● Gordon Research Conference <Bacterial cell surface> (United States, 1996)