論文・総説 #equal contributions, *corresponding authors
2025
Higgins KW#, Itoigawa A#, Toda Y, Bellott DW, Anderson R, Márquez R*, Weng J-K*. Rapid expansion and specialization of the TAS2R bitter taste receptor family in amphibians. PLoS Genetics 21(1): e1011533 (2025). DOI: 10.1371/journal.pgen.1011533
2024
Itoigawa A*, Nakagita T, Toda Y. The Remarkable Diversity of Vertebrate Bitter Taste Receptors: Recent Advances in Genomic and Functional Studies. International Jounal of Molecular Sciences 25(23) 12654 (2024). DOI: 10.3390/ijms252312654
Itoigawa A, Toda Y, Kuraku S, Ishimaru Y*. Evolutionary origins of bitter taste receptors in jawed vertebrates. Current Biology 34(7) P271-P272 (2024). DOI: 10.1016/j.cub.2024.02.024 [日本語プレスリリース] [Nature]
Nishihara H#*, Toda Y#, Kuramoto T, Kamohara K, Goto A, Hoshino K, Okada S, Kuraku S, Okabe M, Ishimaru Y*. A vertebrate-wide catalogue of T1R receptors reveals diversity in taste perception. Nature Ecology & Evolution 8(1):111-120 (2024). DOI: 10.1038/s41559-023-02258-8 [日本語プレスリリース]
2022
Liang Q, Ko MC, Ng NSR, Reh B, Lee JGH, Yamashita A, Nishihara H, Toda Y, Baldwin MW*, T1R2-mediated sweet sensing in a lizard, Current Biology 32 (23), R1302-R1303 (2022). DOI: 10.1016/j.cub.2022.10.061
Cramer JF, Miller ET, Ko MC, Liang Q, Cockburn G, Nakagita T, Cardinale M, Fusani L, Toda Y, Baldwin MW,* A single residue confers selective loss of sugar sensing in wrynecks, Current Biology 32 (19), 4270-4278.e5 (2022). DOI: 10.1016/j.cub.2022.07.059
Cockburn G, Ko MC, Sadanandan KR, Miller ET, Nakagita T, Monte A, Cho S, Roura E, Toda Y, Baldwin MW*, Synergism, bifunctionality, and the evolution of a gradual sensory trade-off in hummingbird taste receptors, Molecular Biology and Evolution 39(2):msab367 (2022). DOI: 10.1093/molbev/msab367
2021
Toda Y#, Hayakawa T#, Itoigawa A, Kurihara Y, Nakagita T, Hayashi M, Ashino R, Melin AD, Ishimaru Y, Kawamura S, Imai H, Misaka T*, Evolution of the primate glutamate taste sensor from a nucleotide sensor, Current Biology 31:4641–4649, Correction 4675–4676 (2021). DOI: 10.1016/j.cub.2021.08.002
Shimizu T, Kubozono T, Asaoka R, Toda Y, Ishimaru Y*, Expression profiles and functional characterization of common carp (Cyprinus carpio) T2Rs, Biochemistry and Biophysics Reports 28:101123-101123 (2021). DOI: 10.1016/j.bbrep.2021.101123
Toda Y, Ko MC, Liang Q, Miller ET, Rico-Guevara A, Nakagita T, Sakakibara A, Uemura K, Sackton T, Hayakawa T, Sin SYW, Ishimaru Y, Misaka T, Oteiza P, Crall J, Edwards SV, Buttemer W, Matsumura S, Baldwin MW*, Early origin of sweet perception in the songbird radiation, Science 373:226-231 (2021). DOI:10.1126/science.abf6505
Before 2020
Toda Y, Nakagita T, Hirokawa T, Yamashita Y, Nakajima A, Narukawa M, Ishimaru Y, Uchida R, Misaka T*, Positive/Negative Allosteric Modulation Switching in an Umami Taste Receptor (T1R1/T1R3) by a Natural Flavor Compound, Methional, Scientific Reports 8:11796 (2018). DOI: 10.1038/s41598-018-30315-x
Baldwin MW#*, Toda Y#, Nakagita T, O'Connell MJ, Klasing KC, Misaka T, Edwards SV, Liberles SD*, Evolution of sweet taste perception in hummingbirds by transformation of the ancestral umami receptor, Science 345:929-933 (2014). DOI: 10.1126/science.1255097
Narukawa M#, Toda Y#, Nakagita T, Hayashi Y, Misaka T*, L-Theanine elicits umami taste via the T1R1 + T1R3 umami taste receptor, Amino Acids 46:1583-1587 (2014). DOI: 10.1007/s00726-014-1713-3
Toda Y, Nakagita T, Hayakawa T, Okada S, Narukawa M, Imai H, Ishimaru Y, Misaka T*, Two distinct determinants of ligand specificity in T1R1/T1R3 (the umami taste receptor), The Journal of Biological Chemistry 288: 36863-36877 (2013). DOI: 10.1074/jbc.M113.494443
Toda Y, Okada S, Misaka T*, Establishment of a new cell-based assay to measure the activity of sweeteners in fluorescent food extracts, Journal of Agricultural and Food Chemistry 59: 12131-12138 (2011). doi: 10.1021/jf2029835
Toda Y, Matsuki N*, Shibuya M, Fujioka I, Tamahara S, Ono K, Glial fibrillary acidic protein (GFAP) and anti-GFAP autoantibody in canine necrotizing meningoencephalitis, Veterinary Record 161: 261-264 (2007). DOI: 10.1136/vr.161.8.261