論文・総説 #equal contributions, *corresponding authors
2026
Mizoguchi R, Toda Y, Nagae M, Yoshida T, Matsuura H, Hirata K, Lam VT, Tran DP, Kitao A, Miyanoiri Y, Hosotani M, Ashikawa Y, Ito C, Tsutsumi N, Yasui N, Ishimaru Y, Yamashita A*. Identification and structural characterization of stereochemical promiscuity in a taste receptor. Proc Natl Acad Sci U S A 123(38):e2534924123(2026). DOI:10.1073/pnas.2534924123
Balakrishnan CN#,*, Toda Y#,*, Ko MC#, Wirthlin ME#, Driver RJ#, Bolton PE#, Miller E#, Mendez-Aranda D#, Dikow RB, Frandsen PB, Shogren EH, Bennett KFP, Anderson HL, Bursell MG, Cramer JF, Sadanandan KR, Nakagita T, Pizo MA, Caetano DS, Anciaes M, Ferreira CF, Berv JS, Long KM, Lim HC, Moncrieff AE, Kingston SE, Carreiro NDW, Friedrich SR, Cuta CA, Pease JB, Nevue AA, Tomlinson C, Zimin A, Louder MIM, Brewer MS, Bay RA, Ruegg K, Smith TB, Ishimaru Y, Pfenning AR, Frankl-Vilches C, Gahr M, Mello CV, Kimball RT, Braun EL, Blake JG, Day LB, Ryder TB, Moore IT, Horton BM, Schlinger BA, Fuxjager MJ, Warren WC, DuVal EH, Boyle WA, Loiselle BA, Braun MJ, Baldwin MW*. Genomic and physiological changes in a sexually selected and frugivorous bird radiation. Current Biology 36(12): 3061-3076.e15 (2026). DOI:10.1016/j.cub.2026.05.021[日本語プレスリリース][英語プレスリリース][マックスプランク研究所プレスリリース][科学大・みんなの科学ニュース]
2025
Ji Q, Hou M, Akhtar MS, Hayakawa T, Toda Y, Itoigawa A, Imai H, Ishida T, Melin AD, Kawamura S*. Relaxation of selective constraint on the sweet-taste receptor gene TAS1R2 in lorisiform primates. Scientific Reports 15:38091(2025). DOI:10.1038/s41598-025-23648-x [日本語プレスリリース]
Higgins KW#, Itoigawa A#, Toda Y, Bellott DW, Anderson R, Márquez R*, Weng J-K*. Rapid expansion and specialization of the TAS2R bitter taste receptor family in amphibians. PLoS Genetics 21(1): e1011533 (2025). DOI: 10.1371/journal.pgen.1011533
2024
Itoigawa A*, Nakagita T, Toda Y. The Remarkable Diversity of Vertebrate Bitter Taste Receptors: Recent Advances in Genomic and Functional Studies. International Jounal of Molecular Sciences 25(23) 12654 (2024). DOI: 10.3390/ijms252312654
Itoigawa A, Toda Y, Kuraku S, Ishimaru Y*. Evolutionary origins of bitter taste receptors in jawed vertebrates. Current Biology 34(7) P271-P272 (2024). DOI: 10.1016/j.cub.2024.02.024 [日本語プレスリリース] [Nature]
Nishihara H#*, Toda Y#, Kuramoto T, Kamohara K, Goto A, Hoshino K, Okada S, Kuraku S, Okabe M, Ishimaru Y*. A vertebrate-wide catalogue of T1R receptors reveals diversity in taste perception. Nature Ecology & Evolution 8(1):111-120 (2024). DOI: 10.1038/s41559-023-02258-8 [日本語プレスリリース]
2022
Liang Q, Ko MC, Ng NSR, Reh B, Lee JGH, Yamashita A, Nishihara H, Toda Y, Baldwin MW*, T1R2-mediated sweet sensing in a lizard, Current Biology 32 (23), R1302-R1303 (2022). DOI: 10.1016/j.cub.2022.10.061
Cramer JF, Miller ET, Ko MC, Liang Q, Cockburn G, Nakagita T, Cardinale M, Fusani L, Toda Y, Baldwin MW,* A single residue confers selective loss of sugar sensing in wrynecks, Current Biology 32 (19), 4270-4278.e5 (2022). DOI: 10.1016/j.cub.2022.07.059
Cockburn G, Ko MC, Sadanandan KR, Miller ET, Nakagita T, Monte A, Cho S, Roura E, Toda Y, Baldwin MW*, Synergism, bifunctionality, and the evolution of a gradual sensory trade-off in hummingbird taste receptors, Molecular Biology and Evolution 39(2):msab367 (2022). DOI: 10.1093/molbev/msab367
2021
Toda Y#, Hayakawa T#, Itoigawa A, Kurihara Y, Nakagita T, Hayashi M, Ashino R, Melin AD, Ishimaru Y, Kawamura S, Imai H, Misaka T*, Evolution of the primate glutamate taste sensor from a nucleotide sensor, Current Biology 31:4641–4649, Correction 4675–4676 (2021). DOI: 10.1016/j.cub.2021.08.002
Shimizu T, Kubozono T, Asaoka R, Toda Y, Ishimaru Y*, Expression profiles and functional characterization of common carp (Cyprinus carpio) T2Rs, Biochemistry and Biophysics Reports 28:101123-101123 (2021). DOI: 10.1016/j.bbrep.2021.101123
Toda Y, Ko MC, Liang Q, Miller ET, Rico-Guevara A, Nakagita T, Sakakibara A, Uemura K, Sackton T, Hayakawa T, Sin SYW, Ishimaru Y, Misaka T, Oteiza P, Crall J, Edwards SV, Buttemer W, Matsumura S, Baldwin MW*, Early origin of sweet perception in the songbird radiation, Science 373:226-231 (2021). DOI:10.1126/science.abf6505
Before 2020
Toda Y, Nakagita T, Hirokawa T, Yamashita Y, Nakajima A, Narukawa M, Ishimaru Y, Uchida R, Misaka T*, Positive/Negative Allosteric Modulation Switching in an Umami Taste Receptor (T1R1/T1R3) by a Natural Flavor Compound, Methional, Scientific Reports 8:11796 (2018). DOI: 10.1038/s41598-018-30315-x
Baldwin MW#*, Toda Y#, Nakagita T, O'Connell MJ, Klasing KC, Misaka T, Edwards SV, Liberles SD*, Evolution of sweet taste perception in hummingbirds by transformation of the ancestral umami receptor, Science 345:929-933 (2014). DOI: 10.1126/science.1255097
Narukawa M#, Toda Y#, Nakagita T, Hayashi Y, Misaka T*, L-Theanine elicits umami taste via the T1R1 + T1R3 umami taste receptor, Amino Acids 46:1583-1587 (2014). DOI: 10.1007/s00726-014-1713-3
Toda Y, Nakagita T, Hayakawa T, Okada S, Narukawa M, Imai H, Ishimaru Y, Misaka T*, Two distinct determinants of ligand specificity in T1R1/T1R3 (the umami taste receptor), The Journal of Biological Chemistry 288: 36863-36877 (2013). DOI: 10.1074/jbc.M113.494443
Toda Y, Okada S, Misaka T*, Establishment of a new cell-based assay to measure the activity of sweeteners in fluorescent food extracts, Journal of Agricultural and Food Chemistry 59: 12131-12138 (2011). doi: 10.1021/jf2029835
Toda Y, Matsuki N*, Shibuya M, Fujioka I, Tamahara S, Ono K, Glial fibrillary acidic protein (GFAP) and anti-GFAP autoantibody in canine necrotizing meningoencephalitis, Veterinary Record 161: 261-264 (2007). DOI: 10.1136/vr.161.8.261