症例報告に基づく文献解析
公表された症例報告を収集・比較解析することにより、疾患の特徴、診断過程、臨床検査所見の意義を明らかにする研究に取り組んでいます。
We collect and comparatively analyze published case reports to elucidate disease characteristics, diagnostic processes, and the clinical significance of laboratory findings.
Selected Publications | 関連論文
Anomalous papillary muscle insertion beyond hypertrophic cardiomyopathy: insights from reported cases, Journal of Echocardiography, 2026, DOI: 10.1007/s12574-026-00755-w.
Analysis of Cases Suspected of APL but Ultimately Diagnosed as Non-APL — Hematology Reports（in press）
臨床検査に基づく診断推論
臨床検査所見を起点とした診断推論を研究対象としています。最近では、急性前骨髄球性白血病（APL）との鑑別を要する症例や、ANCA陽性を示す感染性心内膜炎など、診断が困難な疾患・病態について、既報症例の比較解析を行っています。
Our research focuses on diagnostic reasoning based on laboratory findings. Recent investigations have included comparative analyses of published cases involving diagnostically challenging conditions, such as cases requiring differentiation from acute promyelocytic leukemia (APL) and infective endocarditis associated with antineutrophil cytoplasmic antibody (ANCA) positivity.
Selected Publications | 関連論文
Microbiological Patterns of ANCA-Positive Infective Endocarditis: A Laboratory Perspective, Journal of Laboratory Medicine (2026), 10.1515/labmed-2026-0031
Analysis of Cases Suspected of APL but Ultimately Diagnosed as Non-APL — Hematology Reports（in press）
血液悪性腫瘍と分子病態
急性骨髄性白血病（AML）を中心に、疾患の分子病態、分化制御、酸化還元応答、治療抵抗性について解析を進めています。特にmetallothionein、ferroptosis、細胞分化に関わる分子機構に着目しています。
Our research primarily focuses on acute myeloid leukemia (AML), investigating molecular pathogenesis, the regulation of cellular differentiation, redox responses, and mechanisms of therapeutic resistance. Particular attention is given to metallothioneins, ferroptosis, and molecular mechanisms involved in cellular differentiation.
Selected Publications | 関連論文
Metallothioneins as Redox-Adaptive Regulators of Ferroptosis and Therapy Resistance in Cancer: A Mini Review — Oncologie (2026) DOI: 10.1515/oncologie-2026-0304
Metallothioneins Isoforms in Acute Myeloid Leukemia: Divergent Roles in Leukemic Survival, Differentiation, and Stress Adaptation, Hematology Reports, Volume 18 Issue 5, (2026), 10.3390/hematolrep18050062
Targeting Nucleotide Metabolism and Epigenetic Regulation to Overcome the Differentiation Blockade in AML, Leukemia Research Reports, 25, 100586, (2026), doi: 10.1016/j.lrr.2026.100586.
Differentiation Therapy in Acute Myeloid Leukemia: Advances in Phenotypic Screening and CRISPR-based Functional Genomics, Acta Haematologica, Mar 13:1-36, (2026), doi: 10.1159/000551445.
Reawakening Differentiation Therapy in Acute Myeloid Leukemia: A Comprehensive Review of ATRA-Based Combination Strategies, Current Oncology, 33(1), 25; 1-39, (2026), https://doi.org/10.3390/curroncol33010025
A mini-review: the role of glycosylation in acute myeloid leukemia and its potential for treatment, Oncologie, 2025; 27(5): 689–695. https://doi.org/10.1515/oncologie-2025-0155
臨床検査の品質管理
臨床検査の品質保証と向上を目指し、ISO 15189に関連する品質管理など、検査室業務の改善について検討しています。
To improve laboratory quality assurance and patient safety, we investigate quality management in the context of ISO 15189, critical laboratory result reporting and improvements in clinical laboratory operations.
Selected Publications | 関連論文
ISO 15189 Accreditation: Enhancing Laboratory Performance, Safety, and Personnel Competence, Journal of Laboratory Medicine, 50(1), 3-9, 2026, DOI: 10.1515/labmed-2025-0259.
Strengthening Patient Safety through the Integrated Management of Critical Values, Journal of Laboratory Medicine, in press 2026, https://doi.org/10.1515/labmed-2026-0011.