DiNardo CD, Verma D, Baran N, Bhagat TD, Skwarska A, Lodi A, Saxena K, Cai T, Su X, Guerra VA, Poigaialwar G, Kuruvilla VM, Konoplev S, Gordon-Mitchell S, Pradhan K, Aluri S, Hackman GL, Chaudhry S, Collins M, Sweeney SR, Busquets J, Rathore AS, Deng Q, Green MR, Grant S, Demo S, Choudhary GS, Sahu S, Agarwal B, Spodek M, Thiruthuvanathan V, Will B, Steidl U, Tippett GD, Burger J, Borthakur G, Jabbour E, Pemmaraju N, Kadia T, Kornblau S, Daver NG, Naqvi K, Short NJ, Garcia-Manero G, Tiziani S*, Verma A*, Konopleva M*. "Glutaminase inhibition in combination with azacytidine in myelodysplastic syndromes: a phase 1b/2 clinical trial and correlative analyses” Nature Cancer, 5(10):1515-1533 (*equal contribution corresponding authors, 2024)
Collins M, Gorgoglione R, Impedovo V, Pan X, Chakkarai S, Yi SS, Lodi A, Tiziani S "Exploration of the Intracellular Chiral Metabolome in Pediatric BCP-ALL: A Pilot Study Investigating the Metabolic Phenotype of IgH Locus Aberrations" Frontiers in Oncology, doi.org/10.3389/fonc.2024.1413264 (2024)
Balinda HU, Kelly WJ, Kaklamani VG, Lathrop KI, Canola MM, Ghamasaee P, Sareddy GR, Michalek J, Gilbert AR, Surapaneni P, Tiziani S, Pandey R, Chiou J, Lodi A, Floyd JR 2nd, Brenner AJ. "Sacituzumab Govitecan in patients with breast cancer brain metastases and recurrent glioblastoma: a phase 0 window-of-opportunity trial" Nature Communications, 15(1):6707 (2024)
Lu MJ, Busquets J, Impedovo V, Wilson CN, Chan HR, Chang YT, Matsui W, Tiziani S, Cambronne XA. “SLC25A51 Decouples the Mitochondrial NAD+/NADH Ratio to control proliferation of AML cells” Cell Metabolism, 36(4):808-821.e6 (2024)
Liss MA, Dursun F, Hackman GL, Gadallah MI, Saha A, Friedman CA, Rathore AS, Chandra P, White JR, Tiziani S, DiGiovanni J. “Phase 1 Clinical Trial Evaluating Safety, Bioavailability, and Gut Microbiome with a Combination of Curcumin and Ursolic Acid in Lipid Enhanced Capsules” Journal of Traditional and Complementary Medicine, https://doi.org/10.1016/j.jtcme.2024.03.002 (2024)
Stanford SM, Nguyen TP, Chang J, Zhao Z, Hackman GL, Santelli E, Sanders CM, Katiki M, Dondossola E, Brauer BL, Diaz MA, Zhan Y, Ramsey SH, Watson PA, Sankaran B, Paindelli C, Parietti V, Mikos AG, Lodi A, Bagrodia A, Elliott A, McKay RR, Murali R, Tiziani S, Kettenbach AN, Bottini N. “Low molecular weight protein tyrosine phosphatase protects prostate cancer from oxidative stress through a novel role in glutathione production” Science Advances, 10(5), eadg7887 (2024)
Friedman CA, Saha A, Lavender Hackman G, Lu X, Lodi A, Tiziani S, DiGiovanni J. “Novel Two-Tiered Screening Approach Identifies Synergistic Combinations of Natural Compounds for Cancer Prevention and Treatment” Molecular Carcinogenesis, 1-12 (2024)
Hurrish KH, Su Y, Patel S, Ramage CL, Zhao J, Temby BR, Carter JL, Edwards H, Buck SA, Wiley SE, Hüttemann M, Polin L, Kushner J, Dzinic SH, White K, Bao X, Li J, Yang J, Boerner J, Hou Z, Al-Atrash G, Konoplev SN, Busquets J, Tiziani S, Matherly LH, Taub JW, Konopleva M, Ge Y, Baran N. “Enhancing anti-AML activity of venetoclax by isoflavone ME-344 through suppression of OXPHOS and purine biosynthesis” Biochemical Pharmacology, 220, 115981 (2024)
De Leonardis F, Ahmed A, Vozza A, Capobianco L, Riley CL, Barile SN, Di Molfetta D, Tiziani S, DiGiovanni J, Palmieri L, Dolce V, Fiermonte G. “Functional characterization of human mitochondrial uncoupling protein 3” FEBS Letters, 598(3), 338-346 (2024)
Wilder CS, Chiou J, Battenhouse A, Saha A, Chen Z, Kim E, Gadallah MI, Tiziani S, Georgiou G, Stone E, DiGiovanni J. “Enzymatic depletion of L-Met using an engineered human enzyme as a novel therapeutic strategy for melanoma” Molecular Carcinogenesis, 62, 1531-1545 (2023)
Yap TA, Daver N, Mahendra M, Zhang J, Kamiya-Matsuoka C, Meric-Bernstam F, Kantarjian HM, Ravandi F, Collins ME, Francesco MED, Dumbrava EE, Fu S, Gao S, Gay JP, Gera S, Han J, Hong DS, Jabbour EJ, Ju Z, Karp DD, Lodi A, Molina JR, Baran N, Naing A, Ohanian M, Pant S, Pemmaraju N, Bose P, Piha-Paul SA, Rodon J, Salguero C, Sasaki K, Singh AK, Subbiah V, Tsimberidou AM, Xu QA, Yilmaz M, Zhang Q, Li Y, Bristow CA, Bhattacharjee MB, Tiziani S, Heffernan TP, Vellano CP, Jones P, Heijnen CJ, Kavelaars A, Marszalek JR, Konopleva M. "Complex I Inhibitor of Oxidative Phosphorylation in Advanced Solid Tumors and Acute Myeloid Leukemia: Phase I Trials" Nature Medicine, 29, 115-126 (2023)
Lauria G, Curcio R, Lunetti P, Tiziani S, Coppola V, Dolce V, Fiermonte G, Ahmed A “Role of mitochondrial transporters on metabolic rewiring of pancreatic adenocarcinoma: a comprehensive review” Cancers, 15(2), 411 (2023)
Hua X, Li Y, Pentaparthi SR, McGrail DJ, Zou R, Guo L, Shrawat A, Cirillo KM, Li Q, Bhat A, Xu M, Qi D, Singh A, McGrath F, Andrews S, Aung KL, Das J, Zhou Y, Lodi A, Mills GB, Eckhardt SG, Mendillo ML, Tiziani S, Wu E, Huang JH, Sahni N, Yi SS. “mGI-map: Landscape of microRNA regulatory network architecture and functional rerouting in cancer” Cancer Research, 83 (1), 59-81 (2023)
Kosti A, Chiou J, Guardia GDA, Lei X, Balinda H, Landry T, Lu X, Qiao M, Gilbert A, Brenner A, Galante PAF, Tiziani S, Penalva LOF. “ELF4 is a critical component of a miRNA-transcription factor network and regulates glioblastoma receptor signaling and lipid dynamics” Neuro-Oncology, 14, 25(3), 459-470 (2023)
Lodi A, Pandey R, Chiou J, Bhattacharya A, Huang S, Pan X, Burgman B, Yi SS, Tiziani S, Brenner AJ. “Circulating metabolites associated with tumor hypoxia and early response to treatment in Bevacizumab-refractory glioblastoma after combined Bevacizumab and Evofosfamide” Frontiers in Oncology, https://doi.org/10.3389/fonc.2022.900082 (2022)
McClellan B, Gries P, Harlow B, Tiziani S, Jolly C, DeGraffenried L. “An IGF-1R-mTORC1-SRPK2 Signaling Axis Contributes to FASN Regulation in Breast Cancer” BMC Cancer, 22(1):976 (2022)
Lu X, Hackman GL, Saha A, Rathore AS, Collins M, Friedman C, Yi SS, Matsuda F, DiGiovanni J, Lodi A, Tiziani S. “Metabolomics-based phenotypic screens for evaluation of drug synergy via direct-infusion mass spectrometry” iScience, 25 (5), 104221 (2022)
Highlight: DDN, Exploring Drug Discovery and Development: “From Flamingos to Better Cancer Treatments “
Wang H, He X, Zhang L, Dong H, Huang F, Xian J, Li M, Chen W, Lu X, Pathak KV, Huang W, Li Z, Zhang L, Nguyen LXT, Yang L, Feng L, Gordon DJ, Zhang J, Pirrotte P, Chen CW, Salhotra A, Kuo YH, Horne D, Marcucci G, Sykes DB, Tiziani S, Jin H, Wang X, Li L. “Disruption of dNTPs Homeostasis by Ribonucleotide Reductase Hyperactivation Overcomes AML Differentiation Blockade” Blood, The Journal of the American Society of Hematology, 139(26), 3752-3770 (2022)
Hou Z, Lu X, Tiziani S, Fuiman LA. “Nutritional programming by maternal diet alters offspring lipid metabolism in a marine teleost" Fish Physiology and Biochemistry, 11, 1 (2022)
Baran N, Lodi A, Dhungana Y, Herbrich S, Collins M, Sweeney S, Pandey R, Skwarska A, Patel S, Tremblay M, Kuruvilla VM, Cavazos A, Kaplan M, Warmoes MO, Veiga DT, Furudate K, Rojas-Sutterin S, Haman A, Gareau Y, Marinier A, Ma H, Harutyunyan K, Daher M, Garcia LM, Al-Atrash G, Piya S, Ruvolo V, Yang W, Shanmugavelandy SS, Feng N, Gay J, Du D, Yang JJ, Hoff FW, Kaminski M, Tomczak K, Eric Davis R, Herranz D, Ferrando A, Jabbour EJ, Emilia Di Francesco M, Teachey DT, Horton TM, Kornblau S, Rezvani K, Sauvageau G, Gagea M, Andreeff M, Takahashi K, Marszalek JR, Lorenzi PL, Yu J, Tiziani S, Hoang T, Konopleva M. “Inhibition of Mitochondrial complex I reverses the NOTCH1-driven metabolic reprogramming in T-ALL” Nature Communications, 13 (1), 2801 (2022)
Lewis KA, Osier N, Carrasco R, Chiou J, Carter P, Garcia A, Flowers E, Gennatas ED, Nguyen C, Rana A, Brown SA, Tiziani S. "Serine, N-acetylaspartate Differentiate Adolescents with Juvenile Idiopathic Arthritis Compared with Healthy Controls: A Metabolomics Cross-Sectional Study" Pediatric Rheumatology, 20, 12 (2022)
Zhang Q, Riley-Gillis B, Han L, Jia Y, Lodi A, Zhang H, Ganesan S, Pan R, Konoplev SN, Sweeney SR, Ryan JA, Jitkova Y, Dunner K Jr, Grosskurth SE, Vijay P, Ghosh S, Lu C, Ma W, Kurtz S, Ruvolo VR, Ma H, Weng CC, Ramage CL, Baran N, Shi C, Cai T, Davis RE, Battula VL, Mi Y, Wang J, DiNardo CD, Andreeff M, Tyner JW, Schimmer A, Letai A, Padua RA, Bueso-Ramos CE, Tiziani S, Leverson J, Popovic R, Konopleva M. “Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia” Signal Transduction and Targeted Therapy, 7, 51 (2022)
Gorgoglione R, Impedovo V, Riley CL, Fratantonio D, Tiziani S, Palmieri L, Dolce V, Fiermonte G. “Glutamine-derived aspartate biosynthesis in cancer cells: role of mitochondrial transporters and new therapeutic perspectives” Cancers, 14, 245 (2022)
Gries P, Rathore AS, Lu X, Chiou J, Huynh YB, Lodi A, Tiziani S. “Automated Trimethyl Sulfonium Hydroxide Derivatization Method for High-Throughput Fatty Acid Profiling by Gas Chromatography-Mass Spectrometry”, Molecules, 26(20), 6246 (2021)
Lewis KA, Brooks S, Carrasco R, Carter P, Garcia A, Chiou J, Nguyen C, Rana A, Brown SA, Tiziani S, Osier N. “Best Practices for Recruitment of Older Adolescents for Biobanking and Precision Health Research: A Retrospective Analysis Comparing Juvenile Idiopathic Arthritis Cases with Healthy Controls” Pediatric Rheumatology, 19, 169. PMID: 34863185 (2021)
Lu X, Han L, Busquets J, Collins M, Lodi A, Marszalek JR, Konopleva M, Tiziani S. “The combined treatment with the FLT3-inhibitor AC220 and the complex I inhibitor IACS-010759 synergistically depletes wt- and FLT3-mutated acute myeloid leukemia cells”, Frontiers in Oncology, 3158 doi: 10.3389/fonc.2021.686765 (2021)
Zavorka Thomas ME, Lu X, Talebi Z, Jeon JY, Buelow DR, Gibson AA, Uddin ME, Brinton LT, Nguyen J, Collins M, Lodi A, Sweeney SR, Campbell MJ, Sweet DH, Sparreboom A, Lapalombella R, Tiziani S, Baker SD. “Gilteritinib inhibits Glutamine Uptake and Utilization in FLT3-ITD-positive AML”, Molecular Cancer Therapeutics, doi: 10.1158/1535-7163.MCT-21-0071 (2021)
Pandey R, Collins M, Lu X, Sweeney SR, Chiou J, Lodi A, Tiziani S. "Novel Strategy for Untargeted Chiral Metabolomics using Liquid Chromatography-High Resolution Tandem Mass Spectrometry", Analytical Chemistry, 93(14), 5805 (2021)
Stanford SM, Collins M, Diaz MA, Holmes ZJ, Gries P, Bliss MR, Lodi A, Zhang V, Tiziani S*, Bottini N.* “The low molecular weight protein tyrosine phosphatase promotes adipogenesis and subcutaneous adipocyte hypertrophy”, Journal of Cellular Physiology (2021; #equal contribution first authors, *equal contribution corresponding authors)
Hackman GL, Collins M, Lu X, Lodi A, DiGiovanni J, Tiziani S. “Predicting and quantifying antagonistic effects of natural compounds given with chemotherapeutic agents: Applications for high throughput-screening”, Cancers, 12(12), 3714 (2020)
Kosti A, de Araujo PR, Li WQ, Guardia GDA, Chiou J, Yi C, Ray D, Meliso F, Li YM, Delambre T, Qiao M, Burns SS, Lorbeer FK, Georgi F, Flosbach M, Klinnert S, Jenseit A, Lei X, Sandoval CR, Ha K, Zheng H, Pandey R, Gruslova A, Gupta YK, Brenner A, Kokovay E, Hughes TR, Morris QD, Galante PAF, Tiziani S*, Penalva LOF*. “The RNA binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging “cancer metabolism” and epigenetic regulation”, Genome Biology, 6;21(1):195 (2020; *equal contribution corresponding authors)
Choudhury FK, Hackman GL, Lodi A, Tiziani S. “Stable isotope tracing metabolomics to investigate the metabolic activity of bioactive compounds for cancer prevention and treatment”, Cancers, 3;12(8):E2147 (2020)
Lu WC, Saha A, Yan W, Garrison K, Lamb C, Pandey R, Irani S, Lodi A, Lu X, Tiziani S, Zhang YJ, Georgiou G, DiGiovanni J, Stone E. “Enzyme-Mediated Depletion of Serum L-Met Abrogates Prostate Cancer Growth via Multiple Mechanisms without Evidence of Systemic Toxicity” PNAS, 117 (23), 13000-13011 (2020)
Sweeney SR, Collins M, Pandey R, Chiou J, Lodi A, Tiziani S. “Identification of a synergistic combination of dimethylaminoparthenolide and shikonin alters metabolism and inhibits proliferation of pediatric precursor-B cell acute lymphoblastic leukemia” Molecular Carcinogenesis, 59(4), 399-411 (2020)
Pandey R, Gruslova A, Chiou J, Brenner AJ, Tiziani S. “Stable Isotope Dilution LC-HRMS Assay to Determine Free SN-38, Total SN-38, and SN-38G in Tumor Xenograft Model after Intravenous Administration of Antibody-Drug Conjugate (Sacituzumab govitecan)” Analytical Chemistry, 92, 1260-1267 (2020)
Peris-Díaz M, Sweeney SR, Rodak O, Sentandreu E, Tiziani S. “R-MetaboList 2: a flexible tool for metabolite annotation from high-resolution data-independent acquisition mass spectrometry analysis” Metabolites, 9(9), 187 (2019)
Lu X, Lodi A, Konopleva M, Tiziani S.“Three-dimensional leukemia co-culture system for in vitro high-content metabolomics screening” SLAS Discovery, 24(8), 817-828 (2019)
Kshattry S, Saha A, Gries P, Tiziani S, Stone E, Georgiou G, DiGiovanni J. “Targeting antioxidant pathways for suppression of pancreatic tumor growth” Npj Precision Oncology (2019)
Sanchez-Lopez E, Zhong Z, Stubelius A, Sweeney SR, Booshehri LM, Antonucci L, Liu-Bryan R, Lodi A, Terkeltaub R, Lacal JC, Murphy AN, Hoffman HM, Tiziani S, Guma M, Karin M. “Choline uptake and metabolism modulate macrophage IL-1β and IL-18 production” Cell Metabolism, 29, 1-13 (2019)
Triplett TA, Garrison KC, Marshall N, Donkor M, Blazeck J, Lamb C, Qerqez A, Dekker JD, Tanno Y, Lu WC, Karamitros CS, Ford K, Tan B, Zhang XM, McGovern K, Coma S, Kumada Y, Yamany MS, Sentandreu E, Fromm G, Tiziani S, Schreiber TH, Manfredi M, Ehrlich LIR, Stone E, Georgiou G. “Reversal of IDO-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme” Nature Biotechnology, 36, 758–764 (2018)
Narasimhan R, Coras R, Rosenthal SB, Sweeney SR, Lodi A, Tiziani S, Boyle D, Kavanaugh A, Guma M. “Serum metabolomic profiling predicts synovial gene expression in rheumatoid arthritis” Arthritis Research & Therapy, 20, 164-175 (2018)
Molina JR, Sun Y, Protopopova M, Gera S, Bandi M, Bristow C, McAfoos T, Morlacchi P, Ackroyd J, Agip AA, Al-Atrash G, Asara J, Bardenhagen J, Carrillo CC, Carroll C, Chang E, Ciurea S, Cross JB, Czako B, Deem A, Daver N, de Groot JF, Dong JW, Feng N, Gao G, Gay J, Do MG, Greer J, Giuliani V, Han J, Han L, Henry VK, Hirst J, Huang S, Jiang Y, Kang Z, Khor T, Konoplev S, Lin YH, Liu G, Lodi A, Lofton T, Ma H, Mahendra M, Matre P, Mullinax R, Peoples M, Petrocchi A, Rodriguez-Canale J, Serreli R, Shi T, Smith M, Tabe Y, Theroff J, Tiziani S, Xu Q, Zhang Q, Muller F, DePinho RA, Toniatti C, Draetta GF, Heffernan TP, Konopleva M, Jones P, Di Francesco ME, Marszalek JR. “An inhibitor of oxidative phosphorylation exploits cancer vulnerability” Nature Medicine, 24, 1036–1046 (2018)
Sentandreu E, Peris M, Sweeney SR, Chiou J, Muñoz N, Tiziani S. “A survey of Orbitrap All Ion Fragmentation analysis assessed by an R Metabolist Package to Study Small-molecule Metabolites” Chromatographia, 81(7), 981-994 (2018)
Bryant JD, Sweeney SR, Sentandreu E, Shin M, Ipas H, Xhemalce B, Momb J, Tiziani S, Appling DR. “Deletion of the neural tube defect-associated gene Mthfd1l disrupts one-carbon and central energy metabolism in mouse embryos” Journal of Biological Chemistry, 293(16), 5821-5833 (2018)
Brenner A, Zuniga R, Sun JD, Floyd J, Hart CP, Kroll S, Fichtel L, Cavazos D, Caflisch L, Gruslova A, Huang S, Liu Y, Lodi A, Tiziani S. “Hypoxia Activated Evophosphamide for Treatment of Recurrent Bevacizumab-Refractory Glioblastoma: A phase I surgical study” Neuro-Oncology, https://doi.org/10.1093/neuonc/noy015 (2018)
Jose J, Tavares CDJ, Ebelt ND, Lodi A, Edupuganti R, Xie X, Devkota AK, Kaoud TS, Van Den Berg CL, Anslyn EV, Tiziani S, Bartholomeusz C, Dalby KN. “Serotonin Analogs as Inhibitors of Breast Cancer Cell Growth” ACS Medicinal Chemistry Letters, 8(10), 1072-1076 (2017)
Lewis KA, Brown SA, Tiziani S, Carrasco R. “Sociocultural Considerations in Juvenile Arthritis: A Review”, Journal of Pediatric Nursing, 37, 13-21 (2017)
Pandey R, Caflisch L, Lodi A, Brenner AJ, Tiziani S. “Metabolomic signature of brain cancer” Molecular Carcinogenesis, 1-17 (2017)
Lodi A, Saha A, Lu X, Wang B, Sentandreu E, Collins M, Kolonin MG, DiGiovanni J, Tiziani S. “Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism” Npj Precision Oncology, 1:18 (2017)
Highlights:
Lu X, Solmonson A, Lodi A, Nowinski SM, Sentandreu E, Riley CL, Mills EM, Tiziani S. “The cold-induced early metabolomics response analysis of adipose tissue during acute cold exposure in mice” Scientific Reports, 7, 3455 (2017)
Cramer SL, Saha A, Liu J, Tadi S, Tiziani S, Yan W, Triplett K, Lamb C, Alters SE, Rowlinson S, Zhang YJ, Keating MJ, Huang P, DiGiovanni J, Georgiou G, Stone E. “Systemic depletion of serum L-Cyst(e)ine with an engineered human enzyme induces production of reactive oxygen species and suppresses tumor growth in mice” Nature Medicine, 23, 120-127 (2017)
Matre P, Velez J, Jacamo R, Qi Y, Su X, Cai T, Chan SM, Lodi A, Sweeney SR, Ma H, Davis RE, Baran N, Haferlach T, Su X, Flores ER, Gonzalez D, Konoplev S, Samudio I, DiNardo C, Majeti R, Schimmer AD, Li W, Wang T, Tiziani S, Konopleva M. “Inhibiting glutaminase in acute myeloid leukemia: Metabolic dependency of selective acute myeloid leukemia subtypes” Oncotarget, 7(48) 79722-79735 (2016)
Lashinger LM, O'Flanagan CH, Dunlap SM, Rasmussen AJ, Sweeney S, Guo JY, Lodi A, Tiziani S, White E, Hursting SD. “Starving cancer from the outside and inside: separate and combined effects of calorie restriction and autophagy inhibition on Ras-driven tumors” Cancer & Metabolism, 4-18 (2016)
Sweeney SR, Kavanaugh A, Lodi A, Wang B, Boyle D, Tiziani S*, Guma M “Metabolomic Profiling Predicts outcome of Rituximab therapy in Rheumatoid Arthritis.” Rheumatic and Musculoskeletal Diseases, 2(2) e000289 (2016; *equal contribution corresponding authors)
Guma M, Tiziani S, Firestein GS.“Metabolomics in Rheumatoid Arthritis: Desperately Seeking Biomarkers” Nature Reviews Rheumatology 12, 269-281(2016; *equal contribution first authors)
Garcia-Carbonell R, Divakaruni AS, Lodi A, Vicente-Suarez I, Saha A, Cheroutre H, Boss GR, Tiziani S, Murphy AN, Guma M.“Critical role of fibroblast-like synoviocytes glycolytic metabolism in rheumatoid arthritis” Annals of the Rheumatic Diseases, 68(7) 1614-1626 (2016)
Guma M, Sanchez-Lopez E, Lodi A, Garcia-Carbonell R, Tiziani S, Karin M, Lacal JC, Firestein GS. “Choline kinase inhibition in rheumatoid arthritis” Annals of the Rheumatic Diseases 74(7), 1399-1407 (2015)
Purać J, Kojić D, Popović Ž, Vukašinović E, Tiziani S, Günther UL, Grubor-Lajšić G. “Metabolomic analysis of diapausing and non-diapausing larvae of European corn borer Ostrinia nubilalis” Acta Chimica Slovenica, 62(4), 761-767 (2015)
Kang Y, Tiziani S, G Park, Kaul M, Paternostro G. “Protection using Flt3 and PI3Kα inhibitors demonstrates multiple mechanisms of oxidative glutamate toxicity” Nature Communications, 5:3672 (2014)
Tadi S, Sweeney SR, Tiziani S. “Future Perspectives of Metabolomics in Adipocytes” J. Nutrition Health Food Sci. 2(2): 1-7 (2014)
Tiziani S*, Kang Y, Axelrod J, Harjanto R, Piermarocchi C, Roberts W, Paternostro G.* “Metabolomics of the tumor microenvironment in childhood lymphoblastic leukemia” PLoS ONE 8(12), e82859 (2013) (*equal contribution corresponding authors)
Lodi A *, Tiziani S*, Khanim FL, Günther UL, Viant MR, Bunce CM, Drayson MT. “Proton NMR-based metabolic analyses of MRC Myeloma IX serum samples identifies carnitine and acetyl carnitine as novel markers of active disease and demonstrate the value of non empirically presumed poor quality archived patient material” PLoS ONE 8(2), e56422 (2013) (*equal contribution)
Tiziani S, Kang Y, Choi S, Roberts W, Paternostro G. “ “Metabolomic high-content nuclear magnetic resonance-based drug screening of a kinase inhibitor library” Nature Communications, 2:545 (2011)
Lodi A*, Tiziani S*, Khanim FL, Drayson MT, Günther UL, Bunce CM, Viant MR. “Hypoxia Triggers Major Metabolic Changes in AML Cells without Altering Indomethacin-Induced TCA Cycle Deregulation” ACS Chemical Biology 6(2), 169-175 (2011) (*equal first author contribution)
Felluga A and Tiziani S. “Intensive natural distribution as Bernoulli success ratio extension to continuous: enhanced Gaussian, continuous Poisson, and phenomena explanation” (arXiv:1102.0625, 2011)
Khanim FL, Hayden RE, Birtwistle J, Lodi A, Tiziani S, Davies NJ, Ride JP, Viant MR, Günther UL, Mountford JC, Schrewe H, Green RM, Murray JA, Drayson MT and Bunce CM. “Combined bezafibrate and medroxyprogesterone acetate: Potential novel therapy for acute myeloid leukaemia”PLoS ONE 4(12), e8147 (2009)
Romanska HM*, Tiziani S*, Howe R, Günther UL, Gulzar Z, Lalani EN. “NMR detects PI3k/Akt independent Traits Common to Pluripotent Murine Embryonic Stem Cells and their Malignant Counterparts” Neoplasia, 11(12), 1301-1308 (2009) (*equal first author contribution)
Tiziani S, Lodi A, Khanim FL, Viant MR, Bunce CM, Günther UL. “Metabolomic profiling of drug response in leukaemia cell lines” PLoS ONE 4(1), e4251 (2009)
Tiziani S, Lopes V, Günther UL. “Early stage diagnosis of oral cancer using 1H NMR-based metabolomics” Neoplasia, 11(3), 269-276 (2009)
Tiziani S, Emwas AH, Lodi A, Ludwig C, Viant MR, Günther UL. “Optimised Metabolite Extraction Blood Serum for 1H Nuclear Magnetic Resonance Spectroscopy“ Analytical Biochemistry, 377(1), 16-23 (2008)
Tiziani S, Lodi A, Ludwig C, Parsons HM, Viant MR. “Effects of the application of different window functions and projection methods on processing of 1H J-resolved nuclear magnetic resonance spectra for metabolomics” Analytica Chimica Acta, 610(1), 80-88 (2008)
Tiziani S, Schwartz SJ, Vodovotz Y. “Intermolecular interactions in phytochemical model systems studied by NMR diffusion measurements” Food Chemistry, 107, 962-969 (2008)
Lodi A, Tiziani S, Vodovotz Y. “Molecular changes in soy and wheat breads during storage as probed by NMR” Journal of Agricultural and Food Chemistry, 55, 5850-5857 (2007)
Tiziani S, Schwartz SJ, Vodovotz Y. “Profiling of carotenoids in typical red tomato juice by one and two dimensional NMR” Journal of Agricultural and Food Chemistry, 54, 6094-6100 (2006)
Tiziani S, Vodovotz Y. “Rheological studies of a novel functional food: tomato juice with soy germ” Journal of Agricultural and Food Chemistry, 53, 7267-7273 (2005)
Bonutti C, Sussich F, Tiziani S, Cesàro A. “Calorimetric study of the early stage of hyaluronan oxidation”. Chapter in Edited Book: Hyaluronan: Structure, Metabolism, Biological Activities, Therapeutic Applications. Chapter 1: Structure of Hyaluronan and its Properties in Solution. Editors: E.A. Balazs and V.C. Hascall (2003)
Tiziani S, Sussich F, Cesàro A. “The kinetic of periodate oxidation of carbohydrates 2. Polymeric substrates” Carbohydrate Research, 338, 1083-1095 (2003)