1. Le TT, Harlepp S, Guet CC, Dittmar K, Emonet T, Pan T, Cluzel P. Real-time RNA profiling in a single bacterium. Proc Natl Acad Sci USA 10 (26):9160-9164 (2005). PMID: 15967986.
2. Le TT, Emonet T, Harlepp S, Guet CC, Cluzel P. Dynamical determinants of drug-inducible gene expression in a single bacterium. Biophys J 90:3315-3321 (2006). PMID: 16461398.
3. Le TT, Guet CC, Cluzel P. Protein expression enhancement in efflux-deleted mutant bacteria. Protein Expr Purif 48 (1):28-31 (2006). PMID: 16403646.
4. Le TT, Rehrer CW, Huff TB, Nichols MB, Camarillo IG, Cheng JX. Nonlinear optical imaging to evaluate the impact of obesity on mammary gland and tumor stroma. Mol Imaging 6 (3):205-211 (2007). PMID: 17532886.
5. Le TT, Ingeborg IM, Locker MJ, Sturek M, Cheng JX. Label-free molecular imaging of atherosclerotic lesions using multimodal nonlinear optical microscopy. J Biomed Opt 12, 054007 (2007). PMID: 17994895.
6. Wang HW, Le TT, Cheng JX. Label-free imaging of arterial cells and extracellular matrix using a multimodal CARS microscope. Opt Comm 281(7):1813-1822 (2008). PMID: 19343073.
7. Wang HW, Bao N, Le TT, Lu C, Cheng JX. Microfluidic CARS cytometry. Opt Express 16(8):5782-5789 (2008). PMID: 18542688. [Biophotonics News]
8. Le TT, Huff TB, Cheng JX. Coherent anti-Stokes Raman scattering imaging of lipids in cancer metastasis. BMC Cancer 9:42 (2009). PMID: 19183472. [Biophotonics News]
9. Le TT & Cheng JX. Single-cell profiling reveals the origin of phenotypic variability in adipogenesis. PLoS ONE 4(4):e5189 (2009). PMID: 19357775. [C&EN News]
10. Slipchenko MN, Le TT, Chen H, Cheng JX. A compound Raman microscope for high-speed imaging and spectral analysis of lipid bodies. J Phys Chem B, 113:7681-7686 (2009). PMID: 19422201.
11. Le TT, Duren HM, Slipchenko MN, Hu CD, Cheng JX. Label-free quantitative analysis of lipid metabolism in living C elegans. J Lipid Res, 51:672-677 (2010). PMID: 19776402.
12. Bao N, Le TT, Cheng JX, Lu C. Microfluidic electroporation of tumor and blood cells. Integr Biol 2:113-120 (2010). PMID: 20473389.
13. Yen K*, Le TT*, Bansal A, Narasimhan SD, Cheng JX, Tissenbaum HA. A comparative study of fat storage quantitation in nematode Caenorhabditis elegans using label and label-free methods. PLoS ONE 5(9): e12810 (2010). PMID: 20862331. *Equal Contribution.
14. Elle IC, Simonsen KT, Olsen LCB, Birck PK, Ehmsen S, Tuck S, Le TT, Færgeman NJ. Tissue- and paralogue-specific functions of acyl-coA binding proteins in lipid metabolism in C. elegans. Biochem J. 437 (2): 231-241 (2011). PMID: 21539519.
15. Kim CY, Le TT, Chen CH, Cheng JX, Kim KH. Curcumin inhibits adipocyte differentiation through modulation of mitotic clonal expansion. J Nutr Biochem 22(10): 910-920 (2011). PMID: 21189228.
16. Urasaki Y, Johlfs MG, Fiscus RR, Le TT. Imaging metabolic and immunity cells of visceral adipose tissues with multimodal nonlinear optical microscopy. PLoS ONE 7(6): e38418 (2012). PMID: 22701636.
17. Mitra R, Chao O, Urasaki Y, Goodman OB, Le TT. Detection of lipid-lich prostate circulating tumour cells with coherent anti-Stokes Raman scattering microscopy. BMC Cancer 12:540 (2012). PMID: 23171028.
18. Le TT, Ziemba A, Urasaki Y, Brotman S, Pizzorno G. Label-free evaluation of hepatic microvesicular steatosis with multimodal coherent anti-Stokes Raman scattering microscopy. PLoS ONE 7(11): e51092 (2012). PMID: 23226469.
19. Salameh TS, Le TT, Nichols MB, Kingsbury E, Cheng JX, Camarillo IG. An ex vivo co-culture model system to define stroma-epithelial interactions in breast cancer. Intl J Cancer Res 132(2):288-296 (2013). PMID: 22696278.
20. Lapierre LR, Silvestrini MJ, Nunez L, Ames K, Wong S, Le TT, Hansen M, Melendez A. Autophagy genes are required for normal lipid levels in C. elegans. Autophagy 9(3):1-9 (2013). PMID: 23321914.
21. Rappa G, Mercapide J, Anzanello F, Le TT, Johlfs MG, Fiscus RR, Wilsch-Brauninger M, Corbeil D, Lorico A. Wnt Interaction and extracellular release of prominin-1/CD133 in human malignant melanoma cells. Exp Cell Res 319(6):810-819 (2013). PMID: 23318676.
22. Le TT, Ziemba A, Urasaki Y, Hayes E, Brotman S, Pizzorno G. Disruption of uridine homeostasis links liver pyrimidine metabolism to lipid accumulation. J Lipid Res 54:1044-1057 (2013). PMID: 23355744.
23. Le TT, Urasaki Y, Pizzorno G. Uridine prevents fenofibrate-induced fatty liver. PLoS ONE 9(1): e87179 (2014). PMID: 24475249.
24. Mitra R, Goodman OB, Le TT. Enhanced detection of metastatic prostate cancer cells in human plasma with lipid bodies staining. BMC Cancer 14:91 (2014). PMID: 24528787.
25. Le TT, Urasaki Y, Pizzorno G. Uridine prevents tamoxifen-induced liver lipid droplet accumulation. BMC Pharmacol Toxicol 15:27 (2014). PMID: 24887406.
26. Urasaki Y, Pizzorno G, Le TT. Uridine affects liver protein glycosylation, insulin signaling, and heme biosynthesis. PLoS ONE 9(6):e99728 (2014). PMID: 24918436.
27. Johlfs M, Gorjala P, Urasaki Y, Le TT, Fiscus RR. Capillary isoelectric focusing immunoassay for fat cell differentiation proteomics. PLoS ONE 10(7):e0132105 (2015). PMID: 26132171.
28. Urasaki Y, Pizzorno G, Le TT. Chronic uridine administration induces fatty liver and pre-diabetic conditions in mice. PLoS ONE 11(1): e0146994 (2016). PMID: 26789264
29. Urasaki Y, Fiscus RR, Le TT. Molecular classification of fatty liver by high-throughput profiling of protein post-translational modifications. J Pathol 238:641-650 (2016). PMID: 26725750.
*Invited Commentary. Byrne, FL & Hoehn, KL. Subclassification of fatty liver by its pathogenesis: cIEFing is believing. J Pathol 239:3-5 (2016).
30. Mitra R, Le TT, Gorjala P, Goodman OB. Positive regulation of prostate cancer cell growth by lipid droplet forming and processing enzymes DGAT1 and ABHD5. BMC Cancer 17:631 (2017). PMID: 28877685.
31. Urasaki Y, Zhang C, Cheng JX, Le TT. Quantitative assessment of liver steatosis and affected pathways with molecular imaging and proteomic profiling. Sci Rep 8:3606 (2018). PMID: 29483581.
32. Urasaki Y, Fiscus RR, Le TT. Detection of the cell cycle-regulated negative feedback phosphorylation of the mitogen-activated protein kinases in breast carcinoma using nanofluidic proteomics. Sci Rep 8:9991 (2018). PMID: 29968772.
33. Urasaki Y & Le TT. Differentiation of essential oils using nanofluidic protein post-translational modification profiling. Molecules 24, 2383 (2019). PMID: 31252611.
34. Urasaki Y, Beaumont C, Workman M, Talbot JN, Hill DK, Le TT. Potency assessment of CBD oils by their effects on cell signaling pathways. Nutrients 12, 357 (2020). PMID: 32019055.
35. Urasaki Y, Beaumont C, Workman M, Talbot JN, Hill DK, Le TT. Fast-acting and receptor-mediated regulation of neuronal signaling pathways by copaiba essential oil. Int J Mol Sci 21, 2259 (2020). PMID: 32218156.
36. Urasaki Y, Beaumont C, Talbot JN, Hill DK, Le TT. Akt3 regulates the tissue-specific response to copaiba essential oil. Int J Mol Sci 21, 2851 (2020). PMID: 32325885.
37. Urasaki Y & Le TT. Cinnamaldehyde and curcumin prime Akt2 for insulin-stimulated activation. Nutrients 14, 3301 (2022). PMID: 36014807.
38. Urasaki Y & Le TT. A composition of phytonutrients for glycemic and weight management. Nutrients 14, 3784 (2022). PMID: 36145160.
39. Urasaki Y & Le TT. Functional complementation of anti-adipogenic phytonutrients for obesity prevention and management. Nutrients 14, 4325 (2022). PMID: 36297009.
40. Wang HW, Fu Y, Huff TB, Le TT, Wang H, Cheng JX. Chasing lipids in health and diseases by coherent anti-Stokes Raman scattering microscopy. Vibr Spectrosc 50(1):160-167 (2009). PMID: 19763281.
41. Le TT & Cheng JX. Nonlinear optical imaging of obesity-related health risks. J Innov Opt Health Sci 2 (1):9-25 (2009). PMID: 19784384.
42. Le TT, Yue S, Cheng JX. Shedding new light on lipid biology with CARS microscopy. J Lipid Res 51:3091-3102 (2010). PMID: 20713649.
43. Rappa G, Fargeas GA, Le TT, Corbeil D, Lorico A. An intriguing relationship between lipid droplets, cholesterol-binding protein CD133 and Wnt/β-catenin signaling pathway in carcinogenesis. Stem Cells 33(4):1366-1370 (2015). PMID: 25586989.
44. Lorico A, Rappa G, Corbeil D, Le TT. Observation-driven inquiry: Raman spectroscopic imaging illuminates cancer lipid metabolism. Stem Cell Investig 4:42 (2017). PMID: 28607916.
45. Le TT. Lipid-droplet biology and obesity-related health risks. Chapter 19. Coherent Raman Scattering Microscopy. Taylor & Francis Group, London, England. Editors: Ji-Xin Cheng & Sunney Xie (2012). ISBN: 978-1-4398-6765-5.
46. Chapman W, Le TT, Klevan L. Uniformly functionalized surfaces for microarrays. Patent Application No. US 2002/0182603 A1.
47. Goodman OB, Samlowski W, Le TT. Methods for detecting and collecting circulating tumor cells. Patent Application No. US 2013/0078667 A1.
48. Le TT & Urasaki Y. Composition of phytonutrients for obesity prevention. Patent Application No. US 2022/0378814 A1.
49. Le TT & Urasaki Y. Composition of phytonutrients for diabetes management. Patent Application No. US 2022/0362227 A1.
50. Le TT & Urasaki Y. Flow electroporator device for therapeutic targeting of circulating tumor cells during hemodialysis. US Application No. US 2023/0293801A1.
51. Le TT, Urasaki Y, Fiscus RR. Methods for molecular classification of fatty liver by high-throughput protein post-translational modifications. US Patent No. 10, 591, 478 (2020).
52. Le TT, Mitra R, Urasaki Y, Goodman OB. Methods for therapeutic targeting of circulating tumor cells during hemodialysis. US Patent No. 10, 980, 932 (2021).
53. Le TT. Electrical junction box for a flow electroporation system. US Patent No. D1060268 (2025).
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