Le Lab

Molecular Imaging and Nanofluidic Proteomics for Clinical Diagnosis of Cancer and Fatty Liver Disease

Principal Investigator

Thuc Timothy Le, Ph.D.

Assistant Professor

College of Pharmacy, Roseman University of Health Sciences

10530 Discovery Drive, Las Vegas, NV 89135

Email: tle5@roseman.edu

Tel: 702-802-2820

Google Scholar Profile: https://scholar.google.com/citations?user=mgWx8bkAAAAJ&hl=en

Biography

Dr. Le received a B.A. degree in Molecular and Cell Biology (Biochemistry & Molecular Biology) from the University of California, Berkeley in 1998 and a Ph.D. degree in Biochemistry and Molecular Biology from the University of Chicago in 2005. His graduate research was conducted in the lab of Dr. Philippe Cluzel, who is currently a Gordon McKay Professor of Applied Physics at Harvard University. He completed a post-doctoral fellowship with a Ruth L. Kirschtein National Research Service Award at Purdue University in 2010. His post-doctoral training was mentored by Dr. Ji-Xin Cheng, who is currently a Moustakas Chair Professor in Photonics and Optoelectronics at Boston University. He served as an Assistant Member at the Nevada Cancer Institute from July 2010 to January 2012 and Assistant Research Professor at the Desert Research Institute from February 2012 to May 2014. He joined Roseman University of Health Sciences as an Assistant Professor since July of 2014.

Post-doctoral Research Associate

Yasuyo Urasaki, Ph.D.

College of Pharmacy, Roseman University of Health Sciences

10530 Discovery Drive, Las Vegas, NV 89135

Email: yurasaki@roseman.edu

Tel: 702-802-2828

Google Scholar Profile: https://scholar.google.com/citations?user=Ocz7vR8AAAAJ&hl=en


Biography

Dr. Urasaki received a B.S. degree in Medical Technology from the Tokyo Medical and Dental University, Japan in 2001, a M.S. degree in Health Science from the Graduate School of Tokyo Medical and Dental University, Japan in 2003, and a Ph.D. degree in Internal Medicine from the University of Tokyo, Japan in 2007. She came to United States for her post-doctoral training at the Nevada Cancer Institute since 2007. She joined the Le lab since 2011.

Research Interest

The Le lab specializes in the development and application of nonlinear optical microscopy and nanofluidic proteomics to the studies of cancer and fatty liver disease.

Expertise

  • Cancer biology (breast and prostate)
  • Capillary isoelectric focusing (cIEF) immunoassays
  • Coherent Raman scattering (CRS) microscopy
  • Diet-induced obesity (DIO) animal models
  • Intravital flow cytometry
  • Lipid-droplet biology
  • Molecular diagnostics
  • Nanofluidic proteomics
  • Non-alcoholic fatty liver disease (NAFLD)
  • Non-alcoholic steatohepatitis (NASH)
  • Protein post-translational modification
  • Pyrimidine metabolism